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Recent Developments and Perspectives on the Future of Human and Murine Monoclonal Antibodies in the Diagnosis and Treatment of Cancer

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From Clone to Clinic

Part of the book series: Developments in Biotherapy ((DIBI,volume 1))

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Abstract

Over the past 15 years there has been a substantial effort to develop the potential of monoclonal antibody technology into medical applications. Significant progress has been made, especially in in vitro applications where the superiority of monoclonal antibodies over polyclonal antibodies is undisputed. In vivo success has been achieved in the detection of malignant (1,2) and cardiovascular diseases (3,4) with additional applications in locating deep tissue sites of bacterial infection being identified and developed (5). In colon cancer (2) and malignant melanoma (6) accuracy of tumor detection exceeds 80 percent and, for at least some anatomical sites, tumor detection with radiolabeled monoclonal antibodies is more sensitive than other detection methods (7,8). Within a short time, radiolabeled monoclonal antibodies have achieved a niche in the management of a few types of cancer where the information obtained complements that obtained by other methods and contributes to the effective management of these cancer patients. However, a host of technological difficulties continue to generate questions as to how broadly the monoclonal antibody niche is likely to develop in future years.

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References

  1. Bischof-Delaloye A, Delaloye B, Buchegger F, Gilgien W, Studer A, Curchod S, Givel JC, Mosimann F, Pettavel J, and Mach JP. (1989) ‘Clinical Value of Immunoscinitgraphy in Colorectal Carcinoma Patients: A Prospective Study’, J Nucl Med 30:1646–1656.

    PubMed  CAS  Google Scholar 

  2. Goldenberg DM, Goldenberg H, Sharkey RM, Higgenbotham-Ford E, Lee RE, Swayne LC, Burger KA, Tsai D, Horowitz JA, Hall TC, Pinsky CM, and Hansen HJ. (1990) ‘Clinical Studies of Cancer Radioimmunodetection with Carcinoembryonic Antigen Monoclonal Antibody Fragments Labeled with 123I or 99mTc’, Cancer Res (Suppl) 50; 3:904s-908s.

    Google Scholar 

  3. Rosebrough SF, Kudryk B, Grossman ZD, McAfee JG, Subramanian G, Ritter-Hrncirik CA, Witanowski LS, and Tillapaugh-Fay G. (1985) ‘Radioimmunoimaging of Venous Thrombi using Iodine-131 Monoclonal Antibody’, Radiology 156:515–517.

    PubMed  CAS  Google Scholar 

  4. Khaw BA, Yasuda T, Gold HK, Leinbach RC, Johns JA, Kanke M, Barlai-Kovach M, Strauss HW, and Haber E. (1987) ‘Acute Myocardial Infarct Imaging with Indium-111-Labeled Monoclonal Antimyosin Fab’,J Nucl Med 28:1671–1678.

    PubMed  CAS  Google Scholar 

  5. Rubin RH, Young LS, Hansen PW, Nedelman M, Wilkinson R, Nelles MJ, Callahan R, Khaw BA and Strauss HW. (1988) ‘Specific and Nonspecific Imaging of Localized Fisher Immunotype 1 Pseudomonas aeruginosa Infection with Radiolabeled Monoclonal Antibody’, J Nucl Med 29:651–656.

    PubMed  CAS  Google Scholar 

  6. Eary J, Schroff R, Abrams P, Kasina S, Srinivasan A, Reno J, Woodhouse C and Nelp W. (1987) ‘Imaging of Known and Occult Metastatic Melanoma with Tc-99m Monoclonal Antibody’, J Nucl Med 28:573–574.

    Google Scholar 

  7. Chatal JF, Fumoleau P, Saccarini JC, Thedrez P, Curtet C, bianco-Arco A, Chetanneau A, Peltier P, Kremer M and Guillard Y. (1978) ‘Immunoscintigraphy of Recurrences of Gynecologic Carcinomas’, J Nucl Med 28:1807–1819.

    Google Scholar 

  8. Colcher D, Esteban J, Carrasquillo JA, Sugarbaker P, Reynolds JC, Bryant G, Larson SM and Schlom J. (1987) ‘Complementation of Intracavitary and Intravenous Administration of a Monoclonal Antibody (B72–3) in Patients with Carcinoma’, Cancer Res 47:4128–4224.

    Google Scholar 

  9. Epenetos AA, Briton KE, Mather J, Shepherd J, Granowska M, Taylor-Papadimitriou J, Nimnon C, Durbin H, Hawkins LR and Malpas JS. (1982) ‘Targeting of Iodine-123-Labeled Tumor-Associated Monoclonal Antibodies to Ovarian, Breast, and Gastrointestinal Tumors’, Lancet 2:999–1004.

    Article  PubMed  CAS  Google Scholar 

  10. Mach JP, Chatal JF, Lumbroso JD, Buchegger F, Forni M, Ritschard J, Berche C, Douillard JY, Carrel S, Herlyn M, Steplewski Z and Koprowski H. (1983) Cancer Res 43:5593–5602.

    PubMed  CAS  Google Scholar 

  11. Larson SM, Brown JP, Wright PW, Carrasquillo Ja, Hellstrom I and Hellstrom KE. (1983) ‘Imaging of Melanoma with I-131 Labeled Monoclonal Antibodies’, J Nucl Med 24:123–129.

    PubMed  CAS  Google Scholar 

  12. Moldofsky PJ, Powe J, Mulherne CB, Hammond U, Sears HF, Gatenby Pa, Steplewski Z and Koprowski H. (1983) ‘Metastatic Colon Carcinoma Detected with Radiolabeled F(ab’)2 Monoclonal Antibody Fragments’, Radiology 149:549–555.

    PubMed  CAS  Google Scholar 

  13. Schneck DW, Peterson B, Zimmerman J, Butler F and Dugan W. (1989) ‘Phase I Studies with a Monoclonal Antibody Vinca Conjugate (MC,KS1/4-DAVLB) in Patients with Adenocarcinoma’, Presented at the 4th International Conference on Monoclonal Antibody Immunoconjugates for Cancer, March 30 - April 1, 1989, San Diego, CA.

    Google Scholar 

  14. Lamki LM, Zukiwski AA, Shanken LJ, Legha SS, Benjamin RS, Plager CE, Sank DF, Schroff RW and Murray JL. (1990) ‘Radioimaging of Melanoma Using 99mTc-Labeled Fab Fragment Reactive with a High Molecular Weight Melanoma Antigen’, Cancer Res (Suppl) 50:899s-903s.

    Google Scholar 

  15. Order SE, Klein JL, Leichner PK, Finkcke J, Lollo C and Carlo DJ, (1986) ’90Yttrium Anti-Ferritin - A New Therapeutic Radiolabeled Antibody’, Int J Radiation Oncology Biol Phys 12:227–281.

    Article  Google Scholar 

  16. DeNardo SJ, DeNardo GL, O’Grady LF, Macey DJ, Mills SL, Peng JS, Stewart SL, Epstein AL and McGahan JP. (1986) ‘Radioimmunotherapy of Patients with B-cell Lymphoma Using I-131 LYM-1 Mab’, J Nucl Med 27:903.

    Google Scholar 

  17. Rosen ST, Zimmer AM, Goldman-Leikin R, Gordon LI, Kazikiewicz JM, Kaplan EH, Variakohis D, Marder RJ, Dykewicz MS, Piergies A, Silverstein EA, Roenigk HH and Spies SM. (1987) ‘Radioimmunodetection and Radioimmunotherapy of Cutaneous T Cell Lymphomas Using 131I-Labeled Monoclonal Antibody - an Illinois Cancer Council Study’, J Clin Oncol 5:562–573.

    PubMed  CAS  Google Scholar 

  18. DeNardo SJ, DeNardo GL, O’Grady LF, Levy NB, Mills SL, Macey DJ, McCahan JP, Miller CH and Epstein AL. (1988) ‘Pilot Studies of Radioimmunotherapy of B Cell Lymphoma and Leukemia Using I-131 Lum-1 Monoclonal Antibody’, Antibody Immunoconj Radiopharma 1:17–33

    Google Scholar 

  19. Eary JF, Badger CC, Press O, Fisher d, Brown S, Appelbaum F, Nelp W, Krohn K, Miller R, Levy R, and Bernstein I. (1988) ‘Treatment of B-Cell Lymphoma with I-131 Labeled Murine Monoclonal Antibodies’, J Nucl Med 29:757–758.

    Google Scholar 

  20. Larson SM, Carrasquillo JA, McGuffin RW, Krohn KA, Ferens JM, Hill LD, Beaumier PL, Reynolds JC, Hellstrom KE and Hellstrom I. (1985) ‘Use of I-131 Labeled, Murine Fab Against a High Molecular Weight Antigen of Human,Melanoma’, Radiology 155:487–492.

    PubMed  CAS  Google Scholar 

  21. Stewart JSW, Griffiths M, Munro AJ, Lambert JO, Coulter C and Epentos AA. (1988) ‘Intraperitoneal Radioimmunotherapy for Ovarian Cancer’, AA Epentos, E Oberhausen and RA Reisfeld (eds.), Munich, W. Zuckschwerdt,Verlag, pp. 65–73.

    Google Scholar 

  22. Jain, RK. (1990) ‘Physiological Barriers to Delivery of Monoclonal Antibodies and Other Macromolecules in Tumors’, Cancer Res (Suppl) 50:814s-819s.

    CAS  Google Scholar 

  23. Reynolds JC, Carrasquillo JA, Keenan AM, Lora ME, Sugarbaker P, Abrams P, Foon K, Mulshine JL, Roth J, Colcher D, Schlom J and Larson SM. (1986) ‘Human Anti-Murine Antibodies Following Immunoscintigraphy or Therapy with Radiolabelled Monoclonal Antibodies’, J Nucl Med 27:1022.

    Google Scholar 

  24. Coutney-Luck NS, Epentos AA, Moore R, Larche M, Pectasides D, Dhokia B and Ritter MA. (1986) ‘Development of Primary and Secondary Immune Responses to Mouse Monoclonal Antibodies Used in the Diagnosis and Therapy of Malignant Neoplasms’, Cancer Res 46:6489–6493.

    Google Scholar 

  25. Blottiere HM, Maurel C and Douillard JY. (1987) ‘Immune Function of Patients with Gastrointestinal Carcinoma After Treatment with Multiple Infusions of Monoclonal Antibody 17.1A’, Cancer Res 47:5238–5241.

    PubMed  CAS  Google Scholar 

  26. Hoffman T. (1990) ‘Anticipating, Recognizing, and Preventing Hazards Associated with in Vivo Use of Monoclonal Antibodies: Special Considerations Related to Human Anti-Mouse Antibodiesl’, Cancer Res (Suppl) 50:1049s-1050s.

    CAS  Google Scholar 

  27. Hyams D, Reynolds JC, Carrasquillo JA, Perentesis P, Larson SM, Morin M, Simpson D, Schlom J and Colcher D. (1986) ‘The effect of Circulating Anti-Murine Antibody on the Pharmacokinetics and Biodistribution of Injected Radiolabeled Monoclonal Antibody’, J Nucl Med 27:922.

    Google Scholar 

  28. Buchegger F, Haskell CM, Schreyer M, Scazziga BR, Randin S, Carrel S and Mach JP. (1983) ‘Radiolabeled Fragments of Monoclonal Antibodies Against Carcinoembryonic Antigen for Localization of Human Colon Carcinoma Grafted into Nude Mice’, J Exp Med 158:413–427.

    Article  PubMed  CAS  Google Scholar 

  29. Douillard JY, Chatal JF, Saccavini JC, Curtet C, Kremer M, Peuvrel P and Koprowski H. (1985) ‘Pharmacokinetic Study of Radiolabeled Anti-Colorectal Carcinoma Monoclonal Antibodies in Tumor-Bearing Mice’, Eur J Nucl Med 11:107–113.

    Article  PubMed  CAS  Google Scholar 

  30. Maillet T, Roche AC, Therain F and Mosigny M. (1985) ‘Time Course Localization of Immunoglobulin M Monoclonal Antibody and Its Fragments in Leukemic Tumor-Bearing Mice’, Cancer Immunol Immunother 19:177–182.

    Article  PubMed  CAS  Google Scholar 

  31. Ballou B, Reiland JM, Levine G, Taylor RJ, Shen WC, Ryser JH, Solter D and Hakala TR. (1986) ‘Tumor Location and Drug Targeting Using a Monoclonal Antibody (Anti-SSEA-1) and Antigen-Binding Fragments’, J Surg Oncol 31:1–12.

    Article  PubMed  CAS  Google Scholar 

  32. Morrison SL, Johnson MJ, Herzenberg LA and Oi VT. (1984) ‘Chimeric Human Antibody Molecules: Mouse Antigen-Binding Domains with Human Constant Region Domains’, Proc Natl Acad Sci USA 81:6851–6855.

    Article  PubMed  CAS  Google Scholar 

  33. Ward ES, Güssow, Griffiths AD, Jones PT and Winter G. (1989) ‘Binding Activities of a Repertoire of Single Immunoglobulin Variable Domains Secreted from Escherichia coli’, Nature 341:544–546.

    Article  PubMed  CAS  Google Scholar 

  34. Sastry L, Alting-Mees M, Huse WD, Short JM, Sorge JA, Hay BN, Janda KD, Benkovic SJ and Lerner RA. (1989) ‘Cloning of the Immunological Repertoire in Escherichia coli for Generation of Monoclonal Catalytic Antibodies: Construction of a Heavy Chain Variable Region-Specific cDNA Library’, Proc Natl Acad Sci USA 86:5728–5732.

    Article  PubMed  CAS  Google Scholar 

  35. Hoover HC Jr., Surdyke M, Dnagel RB, Peters LC and Hanna MG Jr. (1984) ‘Delayed Cutaneous Hypersensitivity to autologous Tumor Cells in Colorectal Cancer Patients Immunized with an Autologous Tumor cell-Bacillus-Calmette Guerin Vaccine’, Cancer Res 44:1671–1676.

    Google Scholar 

  36. Hoover HC Jr, Surdyke MG, Dnagel RB, Peters LC and Hanna MG Jr. (1985) ‘Prospectively Randomized Trial of Adjuvant Active Specific Immunotherapy for Human Colorectal Cancer’, Cancer 55:1235–1243.

    Article  Google Scholar 

  37. Haspel MV, McCabe RP, Pomato N, Knowlton JV, Peters LC, Hoover HC Jr and Hanna MG Jr. (1985) ‘Generation of Tumor Cell-Reactive Human Monoclonal Antibodies Using Peripheral Blood Lymphocytes from Actively Immunized Colorectal Carcinoma Patients’, Cancer Res 45:3951–3961.

    PubMed  CAS  Google Scholar 

  38. McCabe RP, Haspel MV, Pomato N, Steis RG, Carrasquillo JA and Hanna MG Jr. (1990) ‘Human Monoclonal Antibodies: Concepts in Development and Application to Colon Cancer’, MP Moyer and GH Poste (eds.), Colon Cancer Cells, Academic Press, pp. 497–518.

    Google Scholar 

  39. Steis RG, Carrasquillo JA, McCabe RP, Bookman MA, Reynolds JC, Larson S, Smith JW, Clark JW, Dailey V, DelVecchio S, Shake N, Pinsky CM, Urba WJ, Haspel MV, Perentesis P, Paris B, Long DL and Hanna MG Jr. (1990) ‘An Evaluation of the Toxicity, Immunogenicity and Tumor Radioimmunodetecting Ability of Two Human Monoclonal Antibodies in Patients with Metastatic Colorectal Carcinoma’, J Clin Oncol (In press)

    Google Scholar 

  40. Bagshawe KD. (1985) ‘Cancer Drug Targeting’, Clinical Radiology 36:545–551.

    Article  PubMed  CAS  Google Scholar 

  41. Senter PD, Saulnter MG, Schreiber GJ, Hirschberg DL, Brown JP, Hellstrom I and Hellstrom KE. (1988) ‘Anti-Tumor Effects of Antibody-Alkaline Phosphatase Conjugates in Combination with Etoposide Phosphate’, Proc Natl Acad Sci USA 85:4842–4846.

    Article  PubMed  CAS  Google Scholar 

  42. Benkovic SJ, Napper AD and Lerner RA. (1988) ‘Catalysis of a Stereospecific Bimolecular Amide Synthesis by an Antibody’, Proc Natl Acad Sci USA 85:5355–5358.

    Article  PubMed  CAS  Google Scholar 

  43. Schultz PG. (1988) ‘The Interplay Between Chemistry and Biology in the Design of Enzymatic Catalysts’, Science 240:426–433.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. R. P. McCabe
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  2. M. V. Haspel
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  3. J. A. Carrasquillo
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  4. R. G. Steis
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  5. N. Pomato
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  6. R. Subramanian
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  7. E. M. Paris
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  8. M. G. Hanna Jr.
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Editor information

Editors and Affiliations

  1. Faculty of Pharmacy, Department of Pharmaceutics, University of Utrecht, Croesestraat 79, Utrecht, 3522 AD, The Netherlands

    D. J. A. Crommelin (Professor of Pharmacology) (Professor of Pharmacology)

  2. TNO Primate Center, Rijswijk, P.O.Box 5815, 2280 HV, The Netherlands

    H. Schellekens (Senior Research Fellow) (Senior Research Fellow)

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© 1990 Springer Science+Business Media Dordrecht

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McCabe, R.P. et al. (1990). Recent Developments and Perspectives on the Future of Human and Murine Monoclonal Antibodies in the Diagnosis and Treatment of Cancer. In: Crommelin, D.J.A., Schellekens, H. (eds) From Clone to Clinic. Developments in Biotherapy, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-3780-5_21

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  • DOI: https://doi.org/10.1007/978-94-011-3780-5_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-5683-0

  • Online ISBN: 978-94-011-3780-5

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