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Pharmacology of Calcium Antagonists Active on Gastrointestinal Calcium Channels

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Calcium Antagonists

Part of the book series: Medical Science Symposia Series ((MSSS,volume 3))

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Abstract

Current drug therapy for functional gastrointestinal (GI) motility disorders [e.g., irritable bowel syndrome (IBS), esophageal spasm] and other disorders (e.g., hypersecretory states, ulcers) of the GI tract has not been effective in many cases. Among the agents that are being used to treat motility disorders of the upper GI tract (e.g., esophageal spasm and achalasia) are metoclopramide, clebopride, domperidone, cholinomi-metics, and anticholinesterases. Anticholinergics, antispasmodics, opiates, manage IBS and other GI motility disorders (see. table 1)

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References

  1. Fleckenstein A. (1977): Annu. Rev. Pharmac. Toxicol, 17: 149–166.

    Article  CAS  Google Scholar 

  2. Fleckenstein A. (1983): Calcium Antagonism in Heart and Smooth Muscle. John Wiley & Sons, New York.

    Google Scholar 

  3. Bolton T. (1979): Physiol. Rev., 43: 606–718.

    Google Scholar 

  4. Bolger G.T., Gengo P.T., Luchowski E.M., Siegel H., Triggle D.J and Janis R.A. (1982): Biochem. Biophys. Res. Commun., 104: 1604–1609.

    Article  PubMed  CAS  Google Scholar 

  5. Zar M.A. and Gooptu D. (1983): Br. J. Clin. Pharmacol, 16: 339–340.

    Article  PubMed  CAS  Google Scholar 

  6. Barone F.C., White R.F., Ormsbee H.S. and Wasserman M.A. (1986): J Pharmacol Exp. Therap., 237: 99–105.

    CAS  Google Scholar 

  7. Godfraind T., Morel N., Salomone S. and Wibo M. (1989): In: Calcium Antagonism in Gastrointestinal Motility, edited by M.O. Christen, T. Godfraind and R.W. McCallum pp. 117–139. Elsevier, Paris.

    Google Scholar 

  8. Galletti F., Zheng W., Gopalakrishnan M., Rutledge A. and Triggle D.J. (1991): Eur. J. Pharmacol, 195: 125–129.

    Article  PubMed  CAS  Google Scholar 

  9. Micheli D., Ratti E., Toson G. and Gaviraghi G. (1991): J. Cardiovasc. Pharmacol, 17 (suppl.4): S1-S8.

    Google Scholar 

  10. De Ponti F., D’Angelo L., Frigo G.M. and Crema A. (1989): Eur. J. Pharmacol., 168: 133–144.

    Article  PubMed  CAS  Google Scholar 

  11. Weiser H.F., Lepsien G., Golenhofen K., Shattenmann G. and Siewert R. (1978): In: Gastrointestinal Motility in Health and Disease, edited by H.L. Duthie pp. 565–572. MTP Press, Lancaster.

    Google Scholar 

  12. Hongo M. (1981): Jpn. J. Smooth Muscle Res., 17: 47–51.

    Article  CAS  Google Scholar 

  13. Blackwell J.N., Holt S. and Heading R.C. (1981): Digestion, 21: 50–56.

    Article  PubMed  CAS  Google Scholar 

  14. Hondo M., Traube M., McAllister R.G. and McCallum R.W. (1984): Gastroenterology, 86: 8–12.

    Google Scholar 

  15. McCallum R.W. (1989): In: Calcium Antagonism in Gastrointestinal Motility, edited by M.O. Christen, T. Godfraind and R.W. McCallum pp. 55–68. Elsevier, Paris.

    Google Scholar 

  16. Bortolotti M. and Labo G. (1981): Gastroenterology, 80: 39–44.

    PubMed  CAS  Google Scholar 

  17. Gelfond M., Rozen P. and Gilat T. (1982): Gastroenterology, 83: 963–969.

    PubMed  CAS  Google Scholar 

  18. Traube M. and McCallum R.W. (1984): Amer. J. Gastroenterol, 79: 892–896.

    CAS  Google Scholar 

  19. Richter J., Dalton C., Bradley L. and Casteel D. (1987): Gastroenterology, 93: 21–28.

    PubMed  CAS  Google Scholar 

  20. Triadafilopoulos G., Aaronson M., Sackel S. and Burakoff R. (1991): Dig. Dis. Sci, 36: 260–267.

    Article  PubMed  CAS  Google Scholar 

  21. Coccia G., Bortolotti M., Michetti P. and Dodero M. (1991): Gut, 32: 604–606.

    Article  PubMed  CAS  Google Scholar 

  22. Robertson C.S., Hardy J.G. and Atkinson M. (1989): Gut, 30: 768–773.

    Article  PubMed  CAS  Google Scholar 

  23. Santander R., Mena I. and Valenzuela J.E. (1986): Gastroenterology, 90: 1614.

    Google Scholar 

  24. Blume M., Schuster M. and Tucker H. (1983): Gastroenterology, 84: 1109.

    Google Scholar 

  25. Narducci F., Pelli M.A., Vedovelli A. and Morelli A. (1983): Gastroenterology, 84: 1256

    Google Scholar 

  26. Narducci F., Bassotti G., Gaburri M., Farroni F. and Morelli A. (1985): Amer. J. Gastroenterol, 80: 317–319.

    CAS  Google Scholar 

  27. Piror A., Harris S.R. and Whorwell P.J. (1987): Gut, 28: 1609–1612.

    Article  Google Scholar 

  28. Sun W.M., Edwards C.A., Prior A., Rao S.S.C. and Read N.W. (1990): Dig. Dis. Sci, 35: 885–890.

    Article  PubMed  CAS  Google Scholar 

  29. Ishizawa M. and Miyazaki E. (1978): Prostaglandins, 16: 591.

    Article  PubMed  CAS  Google Scholar 

  30. Shiba T., Uruno T, Kubota K and Takagi K. (1981): Jpn. J. PharmacoL, 31: 551–561.

    Article  Google Scholar 

  31. Goyal R.K. and Rattan S. (1980): Am. J. Physiol, 238: G40-G44.

    Google Scholar 

  32. Richter J.E., Sinar D.R., Cordova C.M. and Casteel D.O. (1982): Gastroenterology, 82: 882–886.

    PubMed  CAS  Google Scholar 

  33. Maggi C.A., Grimaldi G. and Meli A. (1983): Jpn. J. Pharmacol, 27: 9–14.

    Google Scholar 

  34. Becker B.S. and Burakoff R. (1983): Am. J. Gastroenterol, 78: 773–775.

    PubMed  CAS  Google Scholar 

  35. Kirkegaard P., Christiansen J., Petersen B. and Skov Olsen P. (1982): Scand. J. Gastroenterol, 17: 533–538.

    Article  PubMed  CAS  Google Scholar 

  36. Byrne S. (1987): J. Clin. Psych., 48: 388.

    CAS  Google Scholar 

  37. Richter J.E., Spurling T.J., Cordova C.M. and Castell D.O. (1987): Dig. Dis. Sci., 29: 649–656.

    Article  Google Scholar 

  38. Silverstein B.D., Kramer C.M. and Pope C.E. (1982): Gastroenterology, 82: 1181.

    Google Scholar 

  39. Perez-Mateo M., Sillero C., Cuesta A., Vasquez N. and Berbegal J. (1986): Int. J. Clin. Pharm. Res., 6: 425–427.

    CAS  Google Scholar 

  40. Richter J.E., Dalton C.B., Bradley L.A. and Castell D.O. (1984): Gastroenterology, 93: 21–28.

    Google Scholar 

  41. Cattau E.L., Castell D.O., Johnson D.A., Spurling T.J., Hirszel R., Chobanian S.J. and Richter J.E. (1991): Am. I Gastroenterol, 86: 272–276.

    Google Scholar 

  42. Droogmans G., Himpens B. and Casteels R. (1983): Naunyn-Schmiedeberg’s Arch. Pharmacol, 323–72-77.

    Article  CAS  Google Scholar 

  43. Mironneau J., Lalune C., Mironneau C., Savineau J.-P. and Lavie J.-L. (1984): Eur. J. Pharmacol, 98: 99–107.

    Article  PubMed  CAS  Google Scholar 

  44. Baumgartner A., Drack E., Halter F. and Scheurer U. (1985): Br. J. Pharmacol., 86: 89–94.

    Article  PubMed  CAS  Google Scholar 

  45. Christen M.O. and Tassignon J.P. (1989): Drug. Dev. Res., 18: 101–112.

    Article  CAS  Google Scholar 

  46. Christen M.O. (1990): Gen. Pharmacol, 21: 821–825.

    Article  PubMed  CAS  Google Scholar 

  47. Bretaudeau J. and Foussard-Blanpin O. (1980): J. Pharmacol (Paris), 11: 233–243.

    CAS  Google Scholar 

  48. Bolton T.B., MacKenzie I. and Beech D.J. (1989): In: Calcium Antagonism in Gastrointestinal Motility, edited by M.O. Christen, T. Godfraind and R.W. McCallum pp. 109–115. Elsevier, Paris.

    Google Scholar 

  49. Beech D.J., MacKenzie I., Bolton T.B. and Christen M.O. (1990): Br. J. Pharamcol, 99: 374–378.

    Article  CAS  Google Scholar 

  50. Terada K., Kitamura K. and Hirosi K. (1987): Pflugers Arch., 408: 552–557.

    Article  PubMed  CAS  Google Scholar 

  51. Terada K., Kitamura K. and Kuriyama H. (1987): Pflugers Arch., 408: 558–564.

    Article  PubMed  CAS  Google Scholar 

  52. Terada K., Nakao K., Okabe K., Kitamura K. and Kuriyama H. (1987): Br. J. Pharmacol, 92: 615–625.

    Article  PubMed  CAS  Google Scholar 

  53. Jacquot C., Trouvin J.H. and Christen M.O. (1989): In: Calcium Antagonism in Gastrointestinal Motility, edited by M.O. Christen, T. Godfraind and R.W. McCallum pp. 141–151. Elsevier, Paris.

    Google Scholar 

  54. Bretaudeau J., Foussard-Blanpin O., Baronnet R. and Despraires R. (1975): Thérapie, 10: 919–930.

    Google Scholar 

  55. Roux J.-J., Salmon D. and Reny A. (1980): Gaz. Méd., 87: 1033–1036.

    Google Scholar 

  56. Yousif F.B., Bolger G.T., Ruzycky A. and Triggle D.J. (1985): Can. J. PhysioL Pharmacol, 63: 453–462.

    Article  PubMed  CAS  Google Scholar 

  57. Janis R.A., Silver P. and Triggle D.J. (1987): Adv. Drug Res., 16: 309–591.

    CAS  Google Scholar 

  58. Triggle D.J., Ferrante J., Hawthorn M., Kwon Y.W. and Zheng W. (1989): Calcium Antagonism in Gastrointestinal Motility, edited by M.O. Christen, T. Godfraind and R.W. McCallum pp. 89–107. Elsevier, Paris.

    Google Scholar 

  59. van Breeman C., Aaronson P. and Loutzenhiser R. (1979): Pharmacol Rev., 30: 167–208.

    Google Scholar 

  60. Janis R.A. and Triggle D.J. (1983): J. Med. Chem., 26: 775–785.

    Article  PubMed  CAS  Google Scholar 

  61. Rodenkirchen R., Bayer R., Steiner R., Bossert F., Meyer H. and Moller E. (1978): Naunyn-Schmiedeberg’s Arch. Pharamcol, 310: 69–78.

    Article  Google Scholar 

  62. Szekeres L. and Papp J.G. (1989): Calcium Antagonism in Gastrointestinal Motility, edited by M.O. Christen, T. Godfraind and R.W. McCallum pp. 161–167. Elsevier, Paris.

    Google Scholar 

  63. Xiong Z., Sakai T., Inoue Y., Kitamura K. and Kuriyama H. (1990): Naunyn-Schmiedeberg’s Arch. Pharmacol., 341: 373–380.

    Article  CAS  Google Scholar 

  64. Zobrist R.H. and Mecca T.E. (1990: J. Pharmacol Exp. Ther., 253: 461–465.

    PubMed  CAS  Google Scholar 

  65. Glavin G.B. (1990): Ann. NY Acad. Sci, 597: 293–297.

    Article  PubMed  CAS  Google Scholar 

  66. Sewing K.F. and Hannemann H. (1983): Pharmacology, 27: 1–8.

    Article  Google Scholar 

  67. Canfield P., Coruzzi G., Curwain B. and Rundell T. (1985): Eur. J. PharmacoL, 116: 89–95.

    Article  PubMed  CAS  Google Scholar 

  68. Ogle C.W., Cho C.H., Tong M.C. and Koo M.W.L. (1985): Eur. J. Pharmacol, 112: 399–404.

    Article  PubMed  CAS  Google Scholar 

  69. Wait R., Leahy A., Vee J. and Pollock T. (1985): J. Surg. Res., 38: 424–428.

    Article  PubMed  CAS  Google Scholar 

  70. Koo M., Cho C. and Ogle C. (1986a): J. Pharm. Pharmac., 38: 845–848.

    Article  CAS  Google Scholar 

  71. Brage R., Cortijo J., Esplugues J., Mati-Bonmati E. and Rodriguez C. (1986): Br. J. Pharmacol, 89: 627–633.

    Article  PubMed  CAS  Google Scholar 

  72. Herling A.W., Wirth K. and Bickel M. (1986): Archs. Pharmacol, 332(suppl.): 242.

    Google Scholar 

  73. Ghoneim M.T., El-Dakhakhny M.M., Arab A.M. and Barakat M.K. (1986): Archs. Pharmacol, 334(suppl.): 117.

    Google Scholar 

  74. Glavin G. (1988): J. Pharm. Pharmac., 40: 514–515.

    Article  CAS  Google Scholar 

  75. Hertz F. and Cloarec A. (1989): Gen. Pharmacol, 20: 635–640.

    Article  PubMed  CAS  Google Scholar 

  76. Koo M., Cho C. and Ogle C. (1986): Eur. J. Pharmacol., 120: 355–358

    Article  PubMed  CAS  Google Scholar 

  77. Glavin G. (1989): Dig. Dis. Sci 34: 1477.

    Article  PubMed  CAS  Google Scholar 

  78. McLean A.E.M., McLean M. and Judah J.D. (1965): Int. Rev. Exp. Pathol. 4: 127–157.

    PubMed  CAS  Google Scholar 

  79. Deakin C.D., Fagan E.A. and Williams R. (1991): Hepatol, 12: 251–255.

    Article  CAS  Google Scholar 

  80. Kloner R.A. and Braunwald E. (1987): Am. J. Cardiol, 59: 84B-94B.

    Article  Google Scholar 

  81. Buss W.C., Savage D.D., Stepanek J., Little S.A. and McGuffee L.J. (1988): Eur. J. Pharmacol, 152: 247–253.

    Article  PubMed  CAS  Google Scholar 

  82. Stein Hi., Oosthuizen M.M. and Hinder R.A. (1989): Gastroenterology, 96: A663.

    Google Scholar 

  83. Weichmann B.M., Muccitelli R.M., Tucker S.S. and Wasserman M. A. (1988): J. Pharmac. Exp. Ther., 225: 310–315.

    Google Scholar 

  84. Garay G.L., Annesley P. and Burnett M. (1984): Gastroenterology, 86: 1319.

    Google Scholar 

  85. Landon E.J., Naukam R.J. and Sastry B.V.R. (1986): Biochem. Pharmacol, 35: 697–705.

    Article  PubMed  CAS  Google Scholar 

  86. Takei Y., Marzi I., Kauffman F.C., Currin R.T., Lemasters J.J. and Thurman R.G. (1990): Transplantation, 50: 14–20.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. SOLVAY PHARMA, Laboratoires de Thérapeutique Moderne (L.T.M.), 42, rue Rouget-de-Lisle, B.P. 22, 92151, Suresnes Cedex, France

    M. O. Christen

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  1. M. O. Christen
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Editors and Affiliations

  1. Laboratory of Pharmacology, Catholic University of Louvain, Brussels, Belgium

    T. Godfraind

  2. Institute of Pharmacological Sciences, University of Milan, Milan, Italy

    R. Paoletti  & S. Govoni  & 

  3. Center for Experimental Therapeutics, Baylor Institute of Medicine, Houston, Texas, USA

    P. M. Vanhoutte

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Christen, M.O. (1993). Pharmacology of Calcium Antagonists Active on Gastrointestinal Calcium Channels. In: Godfraind, T., Paoletti, R., Govoni, S., Vanhoutte, P.M. (eds) Calcium Antagonists. Medical Science Symposia Series, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1725-8_41

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  • DOI: https://doi.org/10.1007/978-94-011-1725-8_41

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