Abstract
Before the introduction of intensive high dose chemotherapy, adjuvant treatment did not seem feasible for osteosarcoma with the known chemotherapeutic agents. The metastatic rate for tumors in the limbs was as high as 70% in the first year after definitive surgery and practically all these metastases were situated in the lungs. In Marcove’s material (8), a bone lesion as first metastasis occurred only in 6% of the total group. In Cohen’s review (6) of the Dutch Bone Tumour Committee material, 24/167 = 13% of cases, developed bone metastases, but only in three patients they were not accompanied by lung lesions. It is then logical to investigate the possibilities of radiotherapy to the lungs as a locally directed adjuvant treatment.
EORTC/SIOP Trial 20781.
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References
Abbatucci JS, Quint R, Brune D, Fourre D, Urbajtel M: Place de la radiotherapie dans le traitement des metastases pulmonaires. Irradiation de necessite et irradiation systematiquement prevu. J Radiol Electrol 51:525–529, 1970.
Breur K: Growth rate and radiosensitivity of human tumours. European J Cancer 2:157–171, 1966.
Breur K, Cohen P, Schweisguth O, and Hart AAM: Irradiation of the lungs as an adjuvant therapy in the treatment of osteosarcoma of the limbs. An OERTC randomized study. European J Cancer 14:461-471, 1978.
Burgers JMV, van Glabbeke M, Busson A, et al.: Osteosarcoma of the limbs: report on the EORTC/SIOP Trial 20781, investigating the value of adjuvant treatment with chemotherapy and/or prophylactic lung irradiation (03). Cancer 1988 (in press).
Busson A: Personal communication.
Cohen P: Osteosarcoma of the long bones — clinical observations and experiences in the Netherlands. European J Cancer 14:995–1004, 1976.
Link MP: Adjuvant therapy in the treatment of osteosarcoma. In: Important Advances in Oncology 1986. De Vita, Hellman and Rosenberg(eds.), JB Lippincott, pp. 193–207, 1986.
Marcove RC, Mike V, Hajek JV, Levin AG, Hutter RVP: Osteogenic sarcoma under the age of twenty-one. J Bone Joint Surg 52A:411-423, 1970.
Rosen G, Marcove RC, Huvos AG, et al.: Primary osteogenic sarcoma: eight year experience with adjuvant chemotherapy. J Cancer Res Clin Oncol 2:617–624, 1984.
Winkler K, Bern G, Kotz R et al.: Neoadjuvant chemotherapy of osteogenic sarcoma: result of a cooperative German/Austrian study. J Clin Oncol 106 Suppl:55–67, 1984.
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© 1988 Kluwer Academic Publishers
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Burgers, J.M.V. et al. (1988). Adjuvant Treatment with Radiotherapy to the Lungs and/or Chemotherapy for Osteosarcoma of the Limbs. In: Ryan, J.R., Baker, L.O. (eds) Recent Concepts in Sarcoma Treatment. Developments in Oncology, vol 55. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2691-2_48
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DOI: https://doi.org/10.1007/978-94-009-2691-2_48
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