Abstract
The central 5-HT1A agonist, 8-OH-DPAT has been reported to produce dose-related decreases in blood pressure and heart rate in anaesthetized rats [1, 3]. The hypotensive effect of 8-OH-DPAT appears to be due to a central sympatho-inhibitory effect [4, 5] and these effects are antagonized by spiperone [5], metergoline [3] and (-) pindolol [6] indicating that the decrease in sympathetic tone produced by 8-OH-DPAT is probably due to the stimulation of central 5-HT1A receptors. The propose of the present work was mainly to localize the sites of action of 8-OH-DPAT in the CNS.
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References
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Laubie, M., Drouillat, M., Dabiré, H., Cherqui, C., Schmitt, H. (1990). Ventrolateral medullary pressor area: site of hypotensive and sympatho-inhibitory effects of (±) 8-OH-DPAT in anaesthetized dogs. In: Saxena, P.R., Wallis, D.I., Wouters, W., Bevan, P. (eds) Cardiovascular Pharmacology of 5-Hydroxytryptamine. Developments in CardioCardiovascular Pharmacology of 5-Hydroxytryptamine, vol 106. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0479-8_28
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DOI: https://doi.org/10.1007/978-94-009-0479-8_28
Publisher Name: Springer, Dordrecht
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