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Role of Phosphoinositides at the Neuronal Synapse

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Phosphoinositides II: The Diverse Biological Functions

Part of the book series: Subcellular Biochemistry ((SCBI,volume 59))

Abstract

Synaptic transmission is amongst the most sophisticated and tightly controlled biological phenomena in higher eukaryotes. In the past few decades, tremendous progress has been made in our understanding of the molecular mechanisms underlying multiple facets of neurotransmission, both pre- and postsynaptically. Brought under the spotlight by pioneer studies in the areas of secretion and signal transduction, phosphoinositides and their metabolizing enzymes have been increasingly recognized as key protagonists in fundamental aspects of neurotransmission. Not surprisingly, dysregulation of phosphoinositide metabolism has also been implicated in synaptic malfunction associated with a variety of brain disorders. In the present chapter, we summarize current knowledge on the role of phosphoinositides at the neuronal synapse and highlight some of the outstanding questions in this research field.

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Acknowledgments

Work on phosphoinositides in the Di Paolo lab is funded by NIH grants R01 NS056049, R01 R01HD05547 and R03 AG033212 and by the McKnight Endowment Fund. Belle Chang-Ileto is funded by the NIH (F31 NS058096).

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  1. Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, P&S 12–420C, 10032, New York, USA

    Samuel G. Frere, Belle Chang-Ileto & Gilbert Di Paolo

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  1. Samuel G. Frere
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  2. Belle Chang-Ileto
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Correspondence to Gilbert Di Paolo .

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  1. , NICHD, National Institutes of Health, Convent Drive 49, Bethesda, 20892-4480, Maryland, USA

    Tamas Balla

  2. , Cancer- and Immunobiology, University of Basel, Mattenstrasse 28, Basel, 4058, Switzerland

    Matthias Wymann

  3. , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA

    John D. York

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Frere, S.G., Chang-Ileto, B., Di Paolo, G. (2012). Role of Phosphoinositides at the Neuronal Synapse. In: Balla, T., Wymann, M., York, J. (eds) Phosphoinositides II: The Diverse Biological Functions. Subcellular Biochemistry, vol 59. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-3015-1_5

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