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Tecniche diagnostiche per lo studio dell’apparato cardiovascolare

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Riassunto

Le patologie cardiovascolari rappresentano la principale causa di morte nei paesi industrializzati e, tra esse, più della metà dei decessi è imputabile alla cardiopatia ischemica. Ciò spiega lo sforzo profuso in ambito cardiologico per dotarsi di strategie di valutazione per il riconoscimento della malattia, come pure per il monitoraggio della sua evoluzione e della risposta al trattamento in termini prognostici. Negli ultimi quarant’anni, le applicazioni della medicina nucleare in cardiologia nucleare sono diventate strumento diagnostico e prognostico insostituibile nella gestione del paziente con sospetta o accertata cardiopatia ischemica, grazie allo sviluppo di nuovi radiofarmaci, all’applicazione delle modalità tomografiche di ricostruzione delle immagini (SPECT, PET) e allo sviluppo di acquisizioni sincronizzate con l’elettrocardiogramma, che forniscono la simultanea valutazione di perfusione e funzione ventricolare sinistra.

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Letture consigliate

  1. Bacharach SL, Green MV, Borer JS et al (1979) Instrumentation and data processing in cardiovascular nuclear medicine: evaluation of ventricular function. Semin Nucl Med 9:257–274

    Article  CAS  PubMed  Google Scholar 

  2. Beller GA, Bergmann RS (2004) Myocardial perfusion imaging agents: SPECT and PET. J Nucl Cardiol 11:71–86

    Article  PubMed  Google Scholar 

  3. Chua T, Yin LC, Thiang TH et al (2000) Accuracy of the automated assessment of left ventricular function with gated perfusion SPECT in the presence of perfusion defects and left ventricular dysfunction: correlation with equilibrium radionuclide ventriculography and echocardiography. J Nucl Cardiol 7:301–311

    Article  CAS  PubMed  Google Scholar 

  4. DePuey EG, Nichols K, Dobrinsky C (1993) Left ventricular ejection fraction assessed from gated technetium-99m-sestamibi SPECT. J Nucl Med 34:1871–1876

    CAS  PubMed  Google Scholar 

  5. DePuey EG, Rozansky A (1995) Using gated technetium-99m-sestamibi SPECT to characterize fixed myocardial defects as infarct or artifact. J Nucl Med 36:952–955

    CAS  PubMed  Google Scholar 

  6. de Silva R, Camici PG (1994) The role of positron emission tomography in the investigation of coronary circulatory function in man. Cardiovasc Res 28:1595–1612

    Article  PubMed  Google Scholar 

  7. Di Carli MF, Dorbala S, Meserve J et al (2007) Clinical myocardial perfusion PET/CT. J Nucl Med 48:783–793

    Article  PubMed  Google Scholar 

  8. info/guidelines/gl_cardio_ranuc_img_card_funct.pdf. (Ultimo accesso marzo 2010)

    Google Scholar 

  9. info/guidelines/gl_cardio_myocard_perf.pdf. (Ultimo accesso marzo 2010)

    Google Scholar 

  10. Garcia EV, Faber TL, Cooke CD et al (2007) The increasing role of quantification in clinical nuclear cardiology: the Emory approach. J Nucl Cardiol 14:420–432

    Article  PubMed  Google Scholar 

  11. ch01_ 0403.pdf. (Ultimo accesso marzo 2010)

    Google Scholar 

  12. Germano G, Erel J, Lewin H et al (1997) Automatic quantitation of regional myocardial wall motion and thickening from gated technetium-99m sestamibi myocardial perfusion single-photon emission computed tomography. J Am Coll Cardiol 30:1360–1367

    Article  CAS  PubMed  Google Scholar 

  13. Germano G, Kiat H, Kavanagh PB et al (1995) Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med 36:2138–2147

    CAS  PubMed  Google Scholar 

  14. Gimelli A, Marzullo P, Rovai D (2009) Physiologic risk assessment in stable ischemic heart disease: still superior to the anatomic angiographic approach. J Nucl Cardiol 16:697–700

    Article  PubMed  Google Scholar 

  15. Gimelli A, Rossi G, Landi P et al (2009) Stress/rest myocardial perfusion abnormalities by gated SPECT: still the best predictor of cardiac events in stable ischemic heart disease. J Nucl Med 50:546–553

    Article  PubMed  Google Scholar 

  16. Giorgetti A, Marzullo P, Sambuceti GM et al (2004) Baseline/post-nitrate 99mTc-Tetrofosmin mismatch for the assessment of myocardial viability in patients with severe left ventricular dysfunction: comparison with baseline 99mTc-Tetrofosmin scintigraphy/18FDG-positron emission tomography imaging. J Nucl Cardiol 11:142–151

    Article  PubMed  Google Scholar 

  17. Giorgetti A, Pingitore A, Favilli B et al (2005) Baseline/postnitrate tetrofosmin SPECT for myocardial viability assessment in patients with postischemic severe left ventricular dysfunction: new evidence from MRI. J Nucl Med 46:1285–1293

    PubMed  Google Scholar 

  18. Giorgetti A, Rossi M, Stanislao M et al (2007) Feasibility and diagnostic accuracy of a gated-SPECT imaging protocol: a multicenter study of the myoview imaging optimization group. J Nucl Med 48:1670–1675

    Article  PubMed  Google Scholar 

  19. Go V, Bhatt MR, Hendel RC (2004) The diagnostic and prognostic value of ECG-Gated SPECT myocardial perfusion imaging. J Nucl Med 45:912-921 Hachamovitch R, Berman DS (2005) The use of nuclear cardiology in clinical decision making. Semin Nucl Med 35:62–72

    Google Scholar 

  20. Hachamovitch R, Berman DS, Shaw LJ et al (1998) Incremental prognostic value of myocardial perfusion single photon emission computed tomography for the prediction of cardiac death: differential stratification for risk of cardiac death and myocardial infarction. Circulation 97:535–543

    CAS  PubMed  Google Scholar 

  21. Ioannidis JP, Trikalinos TA, Danias PG (2002) Electrocardiogram-gated single-photon emission computed tomography versus cardiac magnetic resonance imaging for the assessment of left ventricular volumes and ejection fraction: a meta-analysis. J Am Coll Cardiol 39:2059–2068

    Article  PubMed  Google Scholar 

  22. Iskandrian AE, Germano G, VanDecker W et al (1998) Validation of left ventricular volume measurements by gated SPECT 99mTc-labeled sestamibi imaging. J Nucl Cardiol 5:574–578

    Article  CAS  PubMed  Google Scholar 

  23. Myocardial perfusion imaging 3.3. http://interactive.snm.org/docs/155.pdf. (Ultimo accesso marzo 2010)

    Google Scholar 

  24. Nakajima K, Higuchi T, Taki J et al (2001) Accuracy of ventricular volume and ejection fraction measured by gated myocardial SPECT: comparison of 4 software programs. J Nucl Med 42:1571–1578

    CAS  PubMed  Google Scholar 

  25. Nitzsche EU, Choi Y, Czernin J et al (1996) Noninvasive quantification of myocardial blood flow in humans: a direct comparison of the [13N]ammonia and [15O]water techniques. Circulation 93:2000–2006

    CAS  PubMed  Google Scholar 

  26. Rahimtoola SH (1989) The hibernating myocardium. Am Heart J 117:211–221

    Article  CAS  PubMed  Google Scholar 

  27. Russel RR, Zaret BI (2006) Nuclear cardiology: present and future. Curr Probl Cardiol 31:557–629

    Article  Google Scholar 

  28. Sabharwal NK, Lahiri A (2003) Role of myocardial perfusion imaging for risk stratification in suspected or known coronary artery disease. Heart 89:1291–1297

    Article  CAS  PubMed  Google Scholar 

  29. Sambuceti G, Marzullo P, Giorgetti A et al (1994) Global alteration in perfusion response to increasing oxygen consumption in patients with single vessel coronary artery disease. Circulation 90:1696–1705

    CAS  PubMed  Google Scholar 

  30. Sambuceti G, Parodi O, Giorgetti A et al (1995) Microvascular dysfunction in collateral-dependent myocardium. J Am Coll Cardiol 26:615–623

    Article  CAS  PubMed  Google Scholar 

  31. Schelbert HR, Phelps ME, Huang SC et al (1981) 13N-ammonia as an indicator of myocardial blood flow. Circulation 63:1259–1272

    CAS  PubMed  Google Scholar 

  32. Schinkel AFL, Eldhendy A, Bax JJ et al (2006) Prognostic implications of a normal stress Technetium-99m-Tetrofosmin myocardial perfusion study in patients with a healed myocardial infarct and/or previous coronary revascularization. Am J Cardiol97:1–6

    Article  PubMed  Google Scholar 

  33. Sciagrà R (2007) The expanding role of left ventricular functional assessment using gated myocardial perfusion SPECT: the supporting actor is stealing the scene. Eur J Nucl Med Mol Imaging 34:1107–1122

    Article  PubMed  Google Scholar 

  34. Sharir T, Bacher-Stier C, Dhar S et al (2000) Identification of severe and extensive coronary artery disease by postexercise regional wall motion abnormalities in Tc-99m sestamibi gated singlephoton emission computed tomography. Am J Cardiol 86:1171–1175

    Article  CAS  PubMed  Google Scholar 

  35. Smith WH, Kastner RJ, Calnon DA et al (1997) Quantitative gated single photon emission computed tomography imaging: a counts-based method for display and measurement of regional and global ventricular systolic function. J Nucl Cardiol 4:451–463

    Article  CAS  PubMed  Google Scholar 

  36. Tadamura E, Kudoh T, Motooka M et al (1999) Assessment of regional and global left ventricular function by reinjection T1-201 and rest Tc-99m sestamibi ECG-gated SPECT: comparison with three-dimensional magnetic resonance imaging. J Am Coll Cardiol 33:991–997

    Article  CAS  PubMed  Google Scholar 

  37. Thompson RC, Heller GV, Johnson LL et al (2005) Value of attenuation correction on ECG-gated SPECT myocardial perfusion imaging related tobody mass index. J Nucl Cardiol 12:195–202

    Article  PubMed  Google Scholar 

  38. Uren NG, Melin JA, De Bruyne B et al (1994) Myocardial blood flow as a function of coronary stenosis severity in man. N Engl J Med 330:1782–1788

    Article  CAS  PubMed  Google Scholar 

  39. Williams KA, Taillon LA (1996) Left ventricular function in patients with coronary artery disease assessed by gated tomographic myocardial perfusion images: comparison with assessment by contrast ventriculography and first-pass radionuclide angiography. J Am Coll Cardiol 27:173–181

    Article  CAS  PubMed  Google Scholar 

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De Scisciolo, M., Raschillà, R., Raugei, I., Giorgetti, A. (2010). Tecniche diagnostiche per lo studio dell’apparato cardiovascolare. In: Volterrani, D., Mariani, G., Erba, P.A. (eds) Fondamenti di medicina nucleare. Springer, Milano. https://doi.org/10.1007/978-88-470-1685-9_18

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  • DOI: https://doi.org/10.1007/978-88-470-1685-9_18

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1684-2

  • Online ISBN: 978-88-470-1685-9

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