Skip to main content
SpringerLink
Log in

Alloimmunizzazione Rh e malattia emolitica feto-neonatale

  • Chapter
Medicina dell’età prenatale

  • 665 Accesses

Estratto

La presenza sulle emazie fetali di antigeni che la madre non possiede può dar luogo ad un processo di immunizzazione nel caso in cui si abbia il passaggio di eritrociti fetali nel circolo materno. Poiché in questo caso gli antigeni derivano da individui della stessa specie si parla di “alloimmunizzazione”; intendendo, invece, per isoimmunizzazione quella che si verifica tra individui non solo della stessa specie, ma che abbiano anche un’uguale costituzione genetica (gemelli monozigoti).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliografia

  1. Chown B (1954) Anemia from bleeding of the fetus into the mother’s circulation. Lancet 1:1213–1215

    Article  Google Scholar 

  2. Cohen F, Zuelzer WW, Gustafson DC, Evans MM (1964) Mechanism of isoimmunization. The transplacental passage of fetal erythrocytes in homospecific pregnancies. Blood 23:621–646

    PubMed  CAS  Google Scholar 

  3. Bowman JM (1999) Maternal alloimmunization and fetal hemolytic disease. In: Reece EA, Hobbins JC, Mahoney MJ, Petrie RH (eds) Medicine of the fetus and mother. JB Lippincott, Philadelphia

    Google Scholar 

  4. Allen FH, Diamond LK (1957) Eritroblastosis fetalis. Little Brown, Boston

    Google Scholar 

  5. Clarke CA (1975) Rhesus haemolytic disease. University Park Press, Baltimore

    Google Scholar 

  6. Weiner CP (1992) Human fetal bilirubin and fetal hemolytic disease. Am J Obstet Gynecol 116:1449–1454

    Google Scholar 

  7. Nicolaides KH, Warenski JC, Rodeck CH (1985) The relationship of fetal protein concentration and haemoglobin level to the development of hydrops in rhesus isoimmunization. Am J Obstet Gynecol 152:341–344

    PubMed  CAS  Google Scholar 

  8. Sansone G (1972) La prevenzione della malattia emolitica neonatale da Rh. Atti del 1∘ Congresso Nazionale di Medicina Perinatale. Centro Minerva Medica, Roma

    Google Scholar 

  9. Tovey LAD (1986) Haemolytic disease of the newborn. The changing scene. Br J Gynaecol 93:960–966

    CAS  Google Scholar 

  10. Urbaniak SJ (1985) Rh(D) haemolytic disease of the newborn: the changing scene. Br Med J (Clin Res Ed) 291:4–6

    CAS  Google Scholar 

  11. Gottvall T, Hilden JO (1997) Concentration of anti-D antibodies in Rh D alloimmunized pregnant women, as a predictor of anemia and/or hyperbilirubinemia in their newborn infants. Acta Obstet Gynecol Scandinavia 76:733–738

    Article  CAS  Google Scholar 

  12. Liley AW (1961) Liquor amnil analysis in the management of the pregnancy complicated by Rhesus sensitisation. Am J Ostet Gynecol 82:1359–1370

    CAS  Google Scholar 

  13. Yearbook of Obstetrics and Gynecology (1964) Greenhill Ed. Liley

    Google Scholar 

  14. Liley AW (1963) Errors in the assessment of hemolytic disease from amniotic fluid. Am J Obstet Gynecol 86:485–494

    PubMed  CAS  Google Scholar 

  15. Nicolaides KH, Rodeck CH, Mibashan RS, Kemp JR (1986) Have Liley charts outlived their usefulness? Am J Obstet Gynecol 155:90–94

    PubMed  CAS  Google Scholar 

  16. Weiner CP (1996) Management of fetal hemolytic disease by cordocentesis: outcome of affected neonates not requiring transfusion. Fetal Diagn Ther 11:176–178

    Article  Google Scholar 

  17. Bovicelli L (1988) Le tecniche di trasfusione intrauterina del feto. Aggiornamenti in Ostetricia e Ginecologia. CIC, Roma

    Google Scholar 

  18. Orzinska A, Guz K, Brojer E et al (2004) Examination of the RhD gene by non-invasive method in plasma of alloimmunized mother allowed to abandon invasive procedures and to deliver a healthy child. Ginekol Pol 75:963–965

    PubMed  Google Scholar 

  19. Gautier E, Benachi A, Giovangrandi Y et al (2005) Fetal RhD genotyping by maternal serum analysis: a two-year experience. Am J Obstet Gynecol 192:666–669

    Article  PubMed  CAS  Google Scholar 

  20. Moise KJ (2005) Fetal RhD typing with free DNA in maternal plasma. Am J Obstet Gynecol 192:663–665

    Article  PubMed  Google Scholar 

  21. Harkness UF, Spinnato JA (2004) Prevention and management of RhD isoimmunization. Clin Perinatol 31:721–742

    Article  PubMed  Google Scholar 

  22. McLean LK, Hedriana HL, Lanouette JM et al (2004) A retrospective review of isoimmunized pregnancies managed by middle cerebral artery peak systolic velocity. Am J Obstet Gynecol 190:1732–1736

    Article  PubMed  Google Scholar 

  23. Scheier M, Hernandez-Andrade E, Carmo A et al (2004) Prediction of fetal anemia in rhesus disease by measurement of fetal middle cerebral artery peak systolic velocity. Ultrasound Obstet Gynecol 23:432–436

    Article  PubMed  CAS  Google Scholar 

  24. Mari G, Deter RL, Carpenter RL et al (2000) Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses. N Engl J Med 342:9–14

    Article  PubMed  CAS  Google Scholar 

  25. Whitecar PW, Moise KJ Jr (2000) Sonographic methods to detect fetal anemia in red blood cell alloimmunization. Obstet Gynecol Surv 55:240–250

    Article  PubMed  CAS  Google Scholar 

  26. Frigoletto FD, Greene MF, Benacerraf BR et al (1986) Ultrasonographic fetal surveillance in the management of the isoimmunized pregnancy. N Engl J Med 315:430–432

    Article  PubMed  CAS  Google Scholar 

  27. Haugen G, Husby H, Helbig AE et al (2002) Ultrasonographic monitoring of pregnancies complicated by red blood cell alloimmunization in a cohort with mild to moderate risk according to previous obstetric outcome. Acta Obstet Gynecol Scand 81:227–233

    Article  PubMed  Google Scholar 

  28. Schumacher B, Moise KJ (1996) Fetal transfusion for red blood cell alloimmunization in pregnancy. Obstet Gynecol 88:137–150

    Article  PubMed  CAS  Google Scholar 

  29. Poissonier MH, Picone O, Brossard Y et al (2003) Intravenous fetal exchange transfusion before 22 weeks of gestation in early and severe red-cell feto-maternal alloimmunization. Fetal Diagn Ther 18:476–471

    Article  Google Scholar 

  30. Barss VA, Benacerraf BF, Frigoletto FD et al (1998) Management of isoimmunized pregnancy by use of intravascular techniques. Am J Obstet Gynecol 159:932–937

    Google Scholar 

  31. Janssens HM, de Haan MJ, van Kamp L et al (1997) Outcome for children treated with fetal intravascular transfusion because of severe blood group antagonism. J Pediatric 131:373–380

    Article  CAS  Google Scholar 

  32. Grannum PA, Copel JA, Moya FR et al (1988) The reversal of hydrops fetalis by intravascular intrauterine transfusion in severe isoimmune fetal anemia. Am J Obstet Gynecol 158:914–919

    PubMed  CAS  Google Scholar 

  33. Hudon L, Moise KJ, Hegemier SE et al (1998) Long term neurodevelopment outcome after intrauterine transfusion for the treatment of fetal hemolitic disease. Am J Obstet Gynecol 179:858–863

    Article  PubMed  CAS  Google Scholar 

  34. American College of Obstetricians and Gynecologist (1990) Prevention of the isoimmunization. Technical Bulletin no. 147. American College of Obstetricians and Gynecologist, Washington DC

    Google Scholar 

  35. Fung Kee Fung K, Eason E, Crane J et al; Maternal Fetal Medicine Committee, Genetics Committee (2003) Prevention of Rh alloimmunization. J Obstet Gynaecol Can 25:765–773

    Google Scholar 

  36. Pollack W, Ascari WQ, Kochesky RJ et al (1971) Studies on Rh prophylaxis: relationship between doses of anti-Rh and size of antigenic stimulus. Transfusion 11:333–339

    Article  PubMed  CAS  Google Scholar 

  37. Trolle B (1989) Prenatal Rh-immune prophylaxis with 300 mg immune globulin anti-D in the 28th week of pregnancy. Acta Obstet Gynecol Scand 68:45–47

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Centro di Diagnosi Prenatale Dipartimento di Scienze Ginecologiche Ostetriche e della Riproduzione, II Università degli Studi di Napoli, Napoli

    Antonio L. Borrelli & Claudio Ferrara

  2. Department of Obstetrics and Gynaecology, University College Hospital, London, UK

    Paola Borrelli

Authors
  1. Antonio L. Borrelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Claudio Ferrara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Paola Borrelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2008 Springer-Verlag Italia

About this chapter

Cite this chapter

Borrelli, A.L., Ferrara, C., Borrelli, P. (2008). Alloimmunizzazione Rh e malattia emolitica feto-neonatale. In: Medicina dell’età prenatale. Springer, Milano. https://doi.org/10.1007/978-88-470-0688-1_18

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-0688-1_18

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0687-4

  • Online ISBN: 978-88-470-0688-1

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation