Pancreaticobiliary maljunction (PBM) is a congenital anomaly characterized by a union of the pancreatic and biliary ducts, located outside the duodenal wall [1]. This anomalous condition has recently been recognized as a high risk factor for the development of biliary carcinomas later in life [2,3]. Two-way regurgitation occurs in this disorder, as the reflux of pancreatic juice up to the biliary tree and/or of bile up to pancreatic duct, because the sphincter muscle of Oddi does not act functionally in this anomalous union. Therefore, patients with PBM are prone to the development of various pathological conditions of the biliary tract and pancreas, including cholangitis, pancreatitis, biliary and pancreatic calculi, and eventually biliary carcinoma [2–6].
Different animal models have been developed to investigate the pathogenesis of PBM, using dogs [7–9], cats [10], goats [11], lambs [12], and rats [13], and the important documented findings of these studies may contribute to clinical practice. Since the pathogenesis of PBM-related diseases is broad, a variety of species and preparatory methods have been studied. In particular, the association between PBM and biliary carcinogenesis has been investigated extensively; however, few animal experiments have successfully induced biliary carcinoma.
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References
The Japanese Study Group on Pancreaticobiliary Maljunction (JSPBM), The Committee of JSPBM for Diagnostic Criteria. Diagnostic criteria of pancreaticobiliary maljunction. J Hepatobiliary Pancreat Surg 1994 1:219–221.
Matsumoto Y, Fujii H, Itakura J, Matsuda M, Nobukawa B, Suda K. Recent advances in pancreaticobiliary maljunction. J Hepatobiliary Pancreat Surg 2002 9:45–54.
Kimura Y, Nishikawa N, Okita K, Furuhata T, Mizuguchi T, Nobuoka T, Nishimori H, Zenbutsu H, Satoh M, Katsuramaki T, Hirata K. Biliary tract malignancy and chronic inflammation from the perspective of pancreaticobiliary maljunction. Oncology 2005 69 Suppl 1:41–45.
Tashiro S, Imaizumi T, Ohkawa H, Okada A, Katoh T, Kawaharada Y, Shimada H, Takamatsu H, Miyake H, Todani T; Committee for Registration of the Japanese Study Group on Pancreaticobiliary Maljunction. Pancreaticobiliary maljunction: retrospective and nationwide survey in Japan. J Hepatobiliary Pancreat Surg 2003 10:345–351.
Matsumoto Y, Fujii H, Itakura J, Matsuda M, Yang Y, Nobukawa B, Suda K. Pancreaticobiliary maljunction: pathophysiological and clinical aspects and the impact on biliary carcinogenesis. Langenbecks Arch Surg 2003 388:122–131.
Tsuchida A, Itoi T, Aoki T, Koyanagi Y. Carcinogenetic process in gallbladder mucosa with pancreaticobiliary maljunction. Oncol Rep 2003 10:1693–1699.
Kato T, Hebiguchi T, Matsuda K, Yoshino H. Action of pancreatic juice on the bile duct: pathogenesis of congenital choledochal cyst. J Pediatr Surg 1981 16:146–151.
Miyano T, Tokumaru T, Suzuki F, Suda K. Adenoma and stone formation of the biliary tract in puppies that had choledochopancreatic anastomosis. J Pediatr Surg 1989 24:539–542.
Qian D, Kinouchi T, Kunitomo K, Kataoka K, Matin MA, Akimoto S, Komi N, Ohnishi Y. Mutagenicity of the bile of dogs with an experimental model of an anomalous arrangement of the pancreaticobiliary duct. Carcinogenesis 1993 14:743–747.
Kaneko K, Ando H, Umeda T, Murahashi O, Hiraiwa K, Niimi N, Hossain M, Ito T. A new model for pancreaticobiliary maljunction without bile duct dilatation: demonstration of cell proliferation in the gallbladder epithelium. J Surg Res 1996 60:115–121.
Toyosaka A, Nose K, Tomimoto Y. A goat model of dilatation of the common bile duct. Surg Res Comm 1994 16:35–46.
Spitz L. Experimental production of cystic dilatation of the common bile duct in neonatal lambs. J Pediatr Surg 1977 12:39–42.
Nakamura T, Okada A, Higaki J, Tojo H, Okamoto M. Pancreaticobiliary maljunction-associ-ated pancreatitis: an experimental study on the activation of pancreatic phospholipase A2. World J Surg 1996 20:543–550.
Tajima Y, Eto T, Tsunoda T, Tomioka T, Inoue K, Fukahori T, Kanematsu T. Induction of extrahepatic biliary carcinoma by N-nitrosobis(2-oxopropyl)amine in hamsters given cholecystoduodenostomy with dissection of the common duct. Jpn J Cancer Res 1994 85:780–788.
Flanigan PD. Biliary cysts. Ann Surg 1975 182(5):635–643.
Tsuchiya R, Harada N, Ito T, Furukawa M, Yoshihiro I. Malignant tumors in choledochal cysts. Ann Surg 1977 186(1):22–28.
Todani T, Watanabe Y, Toki A, Urushihara N. Carcinoma related to choledochal cysts with internal drainage operations. Surg Gynecol Obstet 1987 164:61–64.
Tsunoda T, Eto T, Koga M, Tomioka T, Motoshima K, Yamaguchi T, Izawa K, Tsuchiya R. Early carcinoma of the extrahepatic bile duct. Jpn J Surg 1989 19(6):691–698.
Kozuka S, Tsubone M, Hachisuka K. Evolution of carcinoma in the extrahepatic bile ducts. Cancer 1984 54(1):65–72.
Terada T, Nakanuma Y. Pathological observations of intrahepatic peribiliary glands in 1,000 consecutive autopsy livers. III. Survey of necroinflammation and cystic dilatation. Hepatology 1990 12:1229–1233.
Coyle KA, Bradley EL 3rd. Cholangiocarcinoma developing after simple excision of a type II choledochal cyst. South Med J 1992 85(5):540–544.
Watanabe Y, Toki A, Todani T. Bile duct cancer developed after cyst excision for choledochal cyst. J Hepatobiliary Pancreat Surg 1999 6(3):207–212.
Strong RW. Late bile duct cancer complicating biliary-enteric anastomosis for benign disease. Am J Surg 1999 177(6):472–474.
Tsuchida A, Kasuya K, Endo M, Saito H, Inoue K, Nagae I, Aoki T, Koyanagi Y. High risk of bile duct carcinogenesis after primary resection of a congenital biliary dilatation. Oncol Rep 2003 10:1183–1187.
Goto N, Yasuda I, Uematsu T, Kanemura N, Takao S, Ando K, Kato T, Osada S, Takao H, Saji S, Shimokawa K, Moriwaki H. Intrahepatic cholangiocarcinoma arising 10 years after the excision of congenital extrahepatic biliary dilation. J Gastroenterol 2001 36:856–862.
Tocchi A, Mazzoni G, Liotta G, Lepre L, Cassini D, Miccini M. Late development of bile duct cancer in patients who had biliary-enteric drainage for benign disease: a follow-up study of more than 1,000 patients. Ann Surg 2001 234(2):210–214.
Hakamada K, Sasaki M, Endoh M, Itoh T, Morita T, Konn M. Late development of bile duct cancer after sphincteroplasty: a ten- to twenty-two-year follow-up study. Surgery 1997 121(5):488–492.
Tanaka M, Takahata S, Konomi H, Matsunaga H, Yokohata K, Takeda T, Utsunomiya N, Ikeda S. Long-term consequence of endoscopic sphincterotomy for bile duct stones. Gastrointest Endosc 1998 48(5):465–469.
Kitajima T, Tajima Y, Onizuka S, Matsuzaki S, Matsuo K, Kanematsu T. Linkage of persistent cholangitis after bilioenterostomy with biliary carcinogenesis in hamsters. J Exp Clin Cancer Res 2000 19(4):453–458.
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Tajima, Y. et al. (2009). Hamster Models of Biliary Carcinoma. In: Tajima, Y., Kuroki, T., Kanematsu, T. (eds) Hepatobiliary and Pancreatic Carcinogenesis in the Hamster. Springer, Tokyo. https://doi.org/10.1007/978-4-431-87773-8_5
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DOI: https://doi.org/10.1007/978-4-431-87773-8_5
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