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Toward Regenerative Medicine for Muscular Dystrophies

Lessons from Regeneration Processes

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Translational Research in Muscular Dystrophy

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Abstract

The US National Institutes of Health defines regenerative medicine as “the process of creating living, functional tissues to repair or replace tissue or organ function lost due to age, disease, damage, or congenital defects.” In many cases, physiological regenerative processes give us multiple clues for creating new therapeutic methodologies. In skeletal muscle fields, the first attempt at regenerative medicine was transplantation of myoblasts into Duchenne muscular (DMD) patients in the early 1990s, but the clinical trials were not successful. At that time, not much was known about the regenerative process in skeletal muscle. However, due to the efforts of scientists and progress in technologies, many important discoveries have emerged. One is the study of muscle stem cells, named satellite cells, and another is identification of muscle-resident mesenchymal progenitors. In this chapter, we focus on satellite cells and mesenchymal progenitors and discuss the newest information concerning them to realize regenerative medicine.

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Acknowledgment

We thank Katherine Ono for comments on the manuscript. S. F. was supported by JSPS KAKENHI grant, Grants-in-Aid for Young Scientists (A) (25702044), Intramural Research Grant (22-5 and 25-5) for Neurological and Psychiatric Disorders of NCNP. A.U. was supported by JSPS KAKENHI grant (24659687), Kato Memorial Bioscience Foundation, ONO Medical Research Foundation, and The Nakatomi Foundation. The authors indicate no potential conflicts of interest. Both S. F. and A.U. belong to “The Research Center Network for Realization of Regenerative Medicine” of the Japan Science and Technology Agency (JST).

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Authors and Affiliations

  1. Division for Therapies Against Intractable Diseases, Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan

    Akiyoshi Uezumi

  2. Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, 565-0871, Suita, Osaka, Japan

    So-ichiro Fukada

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  1. Akiyoshi Uezumi
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  2. So-ichiro Fukada
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Correspondence to So-ichiro Fukada .

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Editors and Affiliations

  1. National Institute of Neuroscience, Kodaira, Tokyo, Tokyo, Japan

    Shin'ichi Takeda

  2. National Institute of Neuroscience, Kodaira, Tokyo, Tokyo, Japan

    Yuko Miyagoe-Suzuki

  3. National Institute of Neuroscience, Kodaira, Tokyo, Tokyo, Japan

    Madoka Mori-Yoshimura

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© 2016 Springer Japan

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Uezumi, A., Fukada, Si. (2016). Toward Regenerative Medicine for Muscular Dystrophies. In: Takeda, S., Miyagoe-Suzuki, Y., Mori-Yoshimura, M. (eds) Translational Research in Muscular Dystrophy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55678-7_7

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  • DOI: https://doi.org/10.1007/978-4-431-55678-7_7

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  • Online ISBN: 978-4-431-55678-7

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