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Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis?

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The Hygiene Hypothesis and Darwinian Medicine

Part of the book series: Progress in Inflammation Research ((PIR))

Abstract

Improvements in modern hygiene and public health have resulted in decreased human contact with organisms associated with so-called ‘dirtier’ environs. These changes, in turn have led to an appreciation of the potential importance of such ‘friendly’ organisms toward proper development of the human immune system. Based on this, a novel hypothesis (the hygiene hypothesis) has been formulated. This idea suggests that a paucity of exposure to environmental pathogens retards proper immune system development, and consequently decreases its ability to effectively thwart a variety of effectors with degenerative consequences, such as those associated with chronic inflammatory responses in diseases as seemingly diverse as those of the gut and the brain. In this chapter, we review current information, including the potential contribution of inheritance to development of hypotheses regarding the pathogenesis of chronic neurodegenerative diseases, especially Alzheimer’s disease. We further explore ways in which the hygiene hypothesis and ideas in Darwinian medicine may play a role in the neuropathogenesis of these diseases.

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Authors and Affiliations

  1. Donald W. Reynolds Institute on Aging and Department of Geriatrics, University of Arkansas for Medical Sciences, 629 Jack Stephens Drive, Little Rock, AR, 72205, USA

    W. Sue T. Griffin

  2. Department of Neurobiology and Developmental Science, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

    W. Sue T. Griffin

  3. Geriatric Research Education Clinical Center, Central Arkansas Veterans Healthcare System, 4300 West Seventh Street, Little Rock, AR, 72205, USA

    W. Sue T. Griffin

  4. Department of Pathology, University of Toledo College of Medicine, Toledo, OH, 43614, USA

    Robert E. Mrak

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  1. Centre for Infectious Diseases and International Health Windeyer Institute for Medical Sciences, University College London, 46 Cleveland Street, London, W1T 4JF, UK

    Graham A. W. Rook

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Griffin, W.S.T., Mrak, R.E. (2009). Is there room for Darwinian medicine and the hygiene hypothesis in Alzheimer pathogenesis?. In: Rook, G.A.W. (eds) The Hygiene Hypothesis and Darwinian Medicine. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8903-1_14

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