Zusammenfassung
Wachstumsfaktoren sind Proteine, agieren als Signalvermittler und können Zellen spezifischer Gewebe auf unterschiedliche Art und Weise in unterschiedliche Richtungen beeinflussen. Sie sind daher u. a. beim Wachstum, der Erhaltung von Geweben sowie bei der Heilung von Verletzungen wichtig. Sie binden an Membranrezeptoren und initiieren teils hochkomplexe Signalwege, wobei sie auf drei verschiedene Arten wirken können: autokrin, parakrin und endokrin. Im vorliegenden Kapitel werden die wichtigsten Wachstumsfaktoren, deren Funktionsweisen und Wirkungen über Signalketten in der Beeinflussung der Gewebetypen Muskulatur, Knochen, Knorpel, Bänder und Sehnen beschrieben. Allerdings muss festgehalten werden, dass viele weitere RCTs notwendig sein werden, um die singuläre oder additive Verwendung von Wachstumsfaktoren in bestimmten regenerativen Phasen derart aufzubereiten, dass sie routinemäßig therapeutisch verwendet werden können.
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Bachl, N., Lorenz, C., Geoffrey, G. (2018). Wachstumsfaktoren unter besonderer Berücksichtigung des muskuloskelettalen Systems. In: Bachl, N., Löllgen, H., Tschan, H., Wackerhage, H., Wessner, B. (eds) Molekulare Sport- und Leistungsphysiologie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1591-6_8
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