Abstract
Animal models provide a basis for clarifying the complex pathogenesis of delayed cerebral vasospasm (DVCS) and for screening of potential therapeutic approaches. The aim of this work was to identify and analyze the most consistent and feasible models and their characteristics for each animal. An online search of the MEDLINE PubMed and EMBASE medical databases (1969 to week 21 of 2007) was performed using the key words “mice”, “rat”, “rabbit”, “canine”, and “primate” in combination with “subarachnoid hemorrhage”, “model”, and “vasospasm”. Seven techniques were mainly used to induce experimental subarachnoid hemorrhage in closed and open cranium approaches. Among the great number of experimental SAH methods and associated parameters only a fistful reliable models can be identified and recommended for experimental work in mice, rats, rabbits, dogs and nonhuman primates.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Ahmad I, Imaizumi S, Shimizu H, Kaminuma T, Ochiai N, Tajima M, Yoshimoto T. Development of calcitonin gene-related peptide slow-release tablet implanted in CSF space for prevention of cerebral vasospasm after experimental subarachnoid haemorrhage. Acta Neurochir (Wien). 1996;138:1230–40
Chan RC, Durity FA, Thompson GB, Nugent RA, Kendall M The role of the p rostacyclin-thromboxane system in cerebral vasospasm following induced subarachnoid hemorrhage in the rabbit. J Neurosurg. 1984;61:1120–28
Chyatte D Prevention of chronic cerebral vasospasm in dogs with ibuprofen and high-dose methylprednisolone. Stroke 1989;20:1021–26
Kamii H, Kato I, Kinouchi H, Chan PH, Epstein CJ, Akabane A, Okamoto H, Yoshimoto T Amelioration of vasospasm after subarachnoid hemorrhage in transgenic mice overexpressing CuZn-superoxide dismutase. Stroke 199930:867–71; discussion 872
Kassell NF, Torner JC, Haley EC, Jr., Jane JA, Adams HP, Kongable GL. The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. J Neurosurg. 1990;73:18–36
Kemaloglu S, Ozkan U, Yilmaz F, Ak E, Acemoglu H, Olmez G, Simsek R, Bakir A. Preventive effects of intracisternal alphatochopherol on cerebral vasospasm in experimental subarachnoid haemorrhage. Yonsei Med J. 2003;44:955–960
Lin CL, Calisaneller T, Ukita N, Dumont AS, Kassell NF, Lee KS A murine model of subarachnoid hemorrhage-induced cerebral vasospasm. J Neurosci Methods. 2003;123:89–97
Lin CL, Su YF, Dumont AS, Shih HC, Lieu AS, Howng SL, Lee KS, Kwan AL The effect of an adenosine A1 receptor agonist in the treatment of experimental subarachnoid hemorrhage-induced cerebrovasospasm. Acta Neurochir (Wien). 2006;148:873–79; discussion 879
McGirt MJ, Parra A, Sheng H, Higuchi Y, Oury TD, Laskowitz DT, Pearlstein RD, Warner DS Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. Stroke 2002;33:2317–23
Vatter H, Weidauer S, Konczalla J, Dettmann E, Zimmermann M, Raabe A, Preibisch C, Zanella FE, Seifert V Time course in the development of cerebral vasospasm after experimental subarachnoid hemorrhage: clinical and neuroradiological assessment of the rat double hemorrhage model. Neurosurgery 2006;58:1190–97; discussion 1190–1197
Zhou C, Yamaguchi M, Kusaka G, Schonholz C, Nanda A, Zhang JH Caspase nhibitors prevent endothelial apoptosis and cerebral vasospasm in dog model of experimental subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2004;24:419–31
Zubkov AY, Nanda A, Zhang JH Signal transduction pathways in cerebral vasospasm. Pathophysiology. 2003;9:47–61
Acknowledgements
We express our gratitude to the staff of the Rockefeller Medical Library, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, UK for their professional assistance in literature search and document delivery. No funds were or will be received for this study.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag/Wien
About this paper
Cite this paper
Marbacher, S., Fandino, J., Kitchen, N. (2011). Characteristics of In Vivo Animal Models of Delayed Cerebral Vasospasm. In: Feng, H., Mao, Y., Zhang, J.H. (eds) Early Brain Injury or Cerebral Vasospasm. Acta Neurochirurgica Supplements, vol 110/1. Springer, Vienna. https://doi.org/10.1007/978-3-7091-0353-1_30
Download citation
DOI: https://doi.org/10.1007/978-3-7091-0353-1_30
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-0352-4
Online ISBN: 978-3-7091-0353-1
eBook Packages: MedicineMedicine (R0)