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Applikation von IPC, HIPEC und PIPAC

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Peritoneale Tumoren und Metastasen

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Zusammenfassung

In der Vergangenheit setzten Onkologen und Chirurgen die Peritonealkarzinose mit einer Fernmetastasierung gleich und betrachteten sie somit als unheilbaren Ausdruck einer fortgeschrittenen malignen Neubildung. Seit mehr als drei Jahrzehnten wurden neue Behandlungsprotokolle entwickelt, die auf einer Kombination aus zytoreduktiver Chirurgie (CRS) und hyperthermer perioperativer intraperitonealer Chemotherapie basieren und ermutigende klinische Resultate in verschiedenen Phase-II- und -III-Studien erbracht haben. Solche kombinierten Protokolle sind inzwischen Behandlungsstandard für einen peritonealen Befall bei Appendixkarzinomen, kolorektalen Karzinomen und beim Peritonealmesotheliom. Wenngleich es – basierend auf den Arbeiten von Sugarbaker et al. – zu einer nahezu universellen Standardisierung der zytoreduktiven Chirurgie gekommen ist, existieren noch immer keine standardisierten und allgemein anerkannten Protokolle für die intraperitoneale Chemotherapie. Dieses Kapitel gibt einen Überblick über die verschiedenen Modalitäten der intraperitonealen Chemotherapie und legt den Fokus dabei auf pharmakologische Variablen.

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Authors and Affiliations

  1. Ziekenhuis Oost-Limburg, Dept of Life Sciences, BIOMED Research Institute, Oncology Research Cluster, Department of Surgical Oncology, Universiteit Hasselt, Schiepse Bos 6, 3600, Genk, Deutschland

    Prof. Dr. med. K. van der Speeten & MSc. L. Lemoine

  2. Evangelische Elisabeth-Klinik Berlin, Abteilung für Allgemein- und Viszeralchirurgie, Lützowstraße 24–26, 10785, Berlin, Deutschland

    PD Dr. med. M. Kilian

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  1. Prof. Dr. med. K. van der Speeten
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  2. PD Dr. med. M. Kilian
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  3. MSc. L. Lemoine
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Correspondence to K. van der Speeten , M. Kilian or L. Lemoine .

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  1. Charité Campus Virchow-Klinikum, Berlin, Deutschland

    Beate Rau

  2. Krankenhaus Barmherzige Brüder, Regensburg, Deutschland

    Pompiliu Piso

  3. Universitätsklinikum Tübingen, Tübingen, Deutschland

    Alfred Königsrainer

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van der Speeten, K., Kilian, M., Lemoine, L. (2018). Applikation von IPC, HIPEC und PIPAC. In: Rau, B., Piso, P., Königsrainer, A. (eds) Peritoneale Tumoren und Metastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-54500-3_13

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