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CNS Neuroprotection pp 335–357Cite as

Developing Gene-Based Neuroprotection Strategies Using Herpes Amplicon Vectors

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 155))

Abstract

Ischemia in the central nervous system produces a heterogeneous pattern of neuronal loss, which is dependent on the extent, duration, and distribution of vessel occlusion. Profound hypoperfusion produces neuronal necrosis in a matter of hour, resulting in plasma membrane rupture and subsequent release of synaptic and somal contents to the interstitial space. An appreciation for the role of elevated extracellular glutamate and intracellular calcium in this pathologic sequence has prompted the development of glutamate and calcium receptor antagonists. Unfortunately, these strategies have not produced in humans the degree of protection observed in animal models of acute necrotic stroke (Zivin and Miller 1999).

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  1. M. W. Halterman
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  2. H. J. Federoff
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Editors and Affiliations

  1. Pfizer Global Research and Development, Ann Arbor Laboratories, 2800 Plymouth Road, Ann Arbor, MI, 48105, USA

    Frank W. Marcoux (Vice President, Biology) (Vice President, Biology)

  2. Department of Neurology Box 8111, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO, 63110, USA

    Dennis W. Choi

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Halterman, M.W., Federoff, H.J. (2002). Developing Gene-Based Neuroprotection Strategies Using Herpes Amplicon Vectors. In: Marcoux, F.W., Choi, D.W. (eds) CNS Neuroprotection. Handbook of Experimental Pharmacology, vol 155. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06274-6_12

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  • DOI: https://doi.org/10.1007/978-3-662-06274-6_12

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