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Endosomes and Cell Signalling

  • Conference paper
Molecular Mechanisms of Membrane Traffic

Part of the book series: NATO ASI Series ((ASIH,volume 74))

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Abstract

The biological responses to many peptide hormones and growth factors are currently under intense investigation. The main area of uncertainty encompasses the transducing events which link initial events at the cell surface to those processes influencing the proteins (egs. enzymes, transporters) effecting the biological response. We have pursued the study of insulin and EGF action by examining the events following ligand-receptor complex formation at the cell surface. Along with others we have observed that these complexes undergo rapid internalization (Posner et al.,1982; Bergeron et al., 1985). In the case of the EGF and insulin receptor this process is accompanied by activation of their respective receptor tyrosine kinases (Cohen et al., 1985; Kay et al., 1986; Khan et al., 1986; Posner et al., 1987).

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Author information

Authors and Affiliations

  1. Depts of Medicine, McGill University and the Royal Victoria Hospital, 687 Pine Avenue, West Montreal, Quebec, Canada, H3A 1A1

    Barry I. Posner

  2. Depts of Anatomy, McGill University and the Royal Victoria Hospital, 687 Pine Avenue, West Montreal, Quebec, Canada, H3A 1A1

    John J. M. Bergeron

Authors
  1. Barry I. Posner
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  2. John J. M. Bergeron
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Editor information

Editors and Affiliations

  1. Department of Medicinal Chemistry, HANS Life Science Research Building, Purdue University, West Lafayette, IN, USA

    D. James Morré

  2. C & S Biology, School of Medicine University of Colorado, Denver, CO, USA

    Kathryn E. Howell

  3. Department of Anatomy and Cell Biology, McGill University, H3A 2B2, Montreal, PQ, Canada

    John J. M. Bergeron

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© 1993 Springer-Verlag Berlin Heidelberg

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Posner, B.I., Bergeron, J.J.M. (1993). Endosomes and Cell Signalling. In: Morré, D.J., Howell, K.E., Bergeron, J.J.M. (eds) Molecular Mechanisms of Membrane Traffic. NATO ASI Series, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02928-2_47

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  • DOI: https://doi.org/10.1007/978-3-662-02928-2_47

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-02930-5

  • Online ISBN: 978-3-662-02928-2

  • eBook Packages: Springer Book Archive

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