Abstract
Gout is a heterogeneous group of disorders of purine metabolism which leads to hyperuricemia and arthritis as well as gout nodules (tophi) from deposition of urate crystals in and around the joints and in the skin. The hyperuricemia in primary gout is related to overproduction or reduced renal excretion of uric acid, while in secondary gout it is due to increased purine biosynthesis and the consequent overproduction of uric acid. The latter is known as a complication in chronic leukemia and other myeloproliferative diseases, in polycythemia vera and after cytostatic treatment, and in extensive psoriasis vulgaris (elevated nucleolysis with secondary hyperuricemia).
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© 1991 Springer-Verlag Berlin Heidelberg
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Braun-Falco, O., Plewig, G., Wolff, H.H., Winkelmann, R.K. (1991). Disorders of Purine Metabolism. In: Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00181-3_47
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DOI: https://doi.org/10.1007/978-3-662-00181-3_47
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