Skip to main content
SpringerLink
Log in
Book cover

Pathologie pp 355–452Cite as

Leukopoese und myeloproliferative Erkrankungen

  • Chapter

Zusammenfassung

Die granulopoetischen Zellen leiten sich von einer als pluripotent bezeichneten Stammzelle ab. Tierexperimentell erweist sich deren Pluripotenz insofern, als die Transplantation solcher Stammzellen auf letal bestrahlte Empfänger in der Milz zur Bildung von Kolonien führt („Cell Forming Unit-Spleen“ = CFU-S), die gemischt aus megakaryozytären, erythroblastischen und granulopoetischen Zellelementen aufgebaut sind und jeweils von einzelnen Stammzellen ausgehen. Solche pluripotenten Stammzellen sind einerseits zur Autoreproduktion fähig, andererseits können sie sich zu determinierten Stammzellen („committed stem cells“) entwickeln, welche gezielt in eine erythropoetische, megakaryozytäre, monozytopoetische oder granulo-zytopoetische Zellentwicklung übergehen.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

Weiterführende Literatur

  1. Begemann H, Rastetter J (1978) Atlas der klinischen Hämatologie. Springer, Berlin Heidelberg New York

    Google Scholar 

  2. Bessis M (1973) Living Blood Cells and their Ultrastructure. Springer, Berlin Heidelberg New York

    Google Scholar 

  3. Queißer W (ed) (1978) Das Knochenmark. Morphologie, Funktion, Diagnostik. Thieme, Stuttgart

    Google Scholar 

  4. Schmalzl F, Huhn D, Schaefer HE (1981) Disorders of the Monocyte Macrophage System. Haemat Blood Transf, Vol 27. Springer, Berlin Heidelberg New York

    Google Scholar 

  5. Williams WJ, Beutler E, Erslev AJ, Rundles RW (1977) Hematology, 2nd edn. McGraw-Hill Book Co, New York

    Google Scholar 

  6. Wintrobe MM, Lee GR, Boggs DR, Bithell TC, Athens JW, Foerster J (1974) Clinical Hematology, 7th edn. Lea & Febiger, Philadelphia

    Google Scholar 

Literatur

  1. Abernathy MR (1966) Döhle bodies associated with uncomplicated pregnancy. Blood 27: 380

    PubMed  CAS  Google Scholar 

  2. Alder A (1939) Über konstitutionell bedingte Granulationsveränderungen der Leukozyten. Dtsch Arch klin Med 183: 372

    Google Scholar 

  3. Alonso K, Dew JM, Starke WR (1972) Thymic alymphoplasia and congenital aleukocytosis (reticular dysgenesia). Arch Path 94: 179

    PubMed  CAS  Google Scholar 

  4. Alper CA, Colten HR, Rosen FS, Rabson AR, Macnab GM, Gear JSS (1972) Homozygous deficiency of C3 in a patient with repeated infections. Lancet II: 1179

    Google Scholar 

  5. AMA (1964, 1965, 1967) Adverse reactions, registry on, tabulations of reports. Panel on Hematoloy. Council on Drugs, AMA, Chicago

    Google Scholar 

  6. Ament ME, Ochs HD (1973) Gastrointestinal manifestations of chronic granulomatous disease of childhood. New Engl J Med 288:382

    PubMed  CAS  Google Scholar 

  7. Athens JW, Raab SO, Haab OP, Mauer AM, Ashenbrucker H, Cartwright GE, Wintrobe MM (1961) Leukokinetic studies. III The distribution of granulocytes in the blood of normal subjects. J clin Invest 40:159

    PubMed  CAS  Google Scholar 

  8. Athens JW, Haab OP, Raab SO, Mauer AM, Ashenbrucker H, Cartwright GE, Wintrobe MM (1961) Leukokinetic studies. III The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjects. J clin Invest 40: 989

    PubMed  CAS  Google Scholar 

  9. Aznar J, Vaya A (1981) Homozygous form of the Pelger-Huët leukocyte anomaly in man. Acta haemat 66: 59

    PubMed  CAS  Google Scholar 

  10. Babior BM, Crowley CH (1983) Chronic granulomatous disease and other disorders of oxidative killing by phagocytes. In: Stanbury JB, Wyngaarden JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease, 5th edn. Mc Graw-Hill, New York, p 1956

    Google Scholar 

  11. Baehner RL, Nathan DG (1968) Quantitative nitroblue tetrazolium test in chronic granulomatous disease. New Engl J Med 278:971

    PubMed  CAS  Google Scholar 

  12. Barth RF, Khurana SK, Vergara GG, Lowman JT, Beckwith JB (1972) Rapidly fatal familial histiocytosis associated with eosinophilia and primary immunological deficiency. Lancet II: 503

    Google Scholar 

  13. Basten A, Beason PB (1970) Mechanism of eosinophilia. II. Role of the lymphocytes. J exp Med 131:1288

    PubMed  CAS  Google Scholar 

  14. Baumann T (1951) Konstitutionelle Panmyelophthise mit multipler Abartung (Fanconi-Syndrome). Ann Paediatr 177: 65

    PubMed  CAS  Google Scholar 

  15. Bedoya V, Grimley PM, Duque O (1969) Chédiak-Higashi Syndrome. Arch Path 88: 340

    PubMed  CAS  Google Scholar 

  16. Begemann WH, van Campagne AL (1952) Homozygous form of Pelger-Huët’s anomaly in man. Acta haemat (Basel) 7:295

    Google Scholar 

  17. Bell TG, Meyers KM, Prieur DJ, Fauci AS, Wolff SM, Padgett GA (1976) Decreased nucleotide and serotonin storage associated with defective function in Chédiak-Higashi syndrome cattle and human platelets. Blood 48:175

    PubMed  CAS  Google Scholar 

  18. Bennett JM, Blume RS, Wolff SM (1969) Characterization and significance of abnormal leukocyte granules in the beige mouse: a possible homologue for Chediak-Higashi aleutian trait. J lab clin Med 73: 235

    PubMed  CAS  Google Scholar 

  19. Berendes H, Bridges RA, Good RA (1957) A fatal granulomatosis of childhood: The clinical study of a new syndrome. Minn Med 40: 309

    PubMed  CAS  Google Scholar 

  20. Bessis M, Bernard J, Seligmann M (1961) Etude cytologique d’un cas de maladie de Chédiak. Nouv Rev franc Hemat 1: 422

    Google Scholar 

  21. Bishop CR, Athens JW, Boggs DR, Warner HR, Cartwright GE, Wintrobe MM (1968) Leukokinetic studies. XIII. A non-steady-state kinetic evaluation of the mechanism of cortisone-induced granulocytosis. J clin Invest 47: 249

    PubMed  CAS  Google Scholar 

  22. Bishop CR, Rothstein G, Ashenbrucker H, Athens JW (1971) Leukokinetic studies. XIV. Blood neutrophil kinetics in chronic, steady-state neutropenia. J clin Invest 50:1678

    PubMed  CAS  Google Scholar 

  23. Bodian M, Sheldon W, Lightwood R (1964) Congenital hypoplasia of the exocrine pancreas. Acta paediatr 53: 282

    PubMed  CAS  Google Scholar 

  24. Boll J (1978) Erkrankungen des granulozytären Systems. In: Queißer W (ed) Das Knochenmark. Thieme, Stuttgart, S 501

    Google Scholar 

  25. Boll J, Koeppen K-M (1978) Die hereditären und konstitutionellen Granulozytopenien. In: Queißer W (ed) Das Knochenmark. Thieme, Stuttgart, S 504

    Google Scholar 

  26. Boseila AWA (1963) Hormonal influence on blood and tissue basophilic granulocytes. Ann NY Acad Sei 103: 394

    CAS  Google Scholar 

  27. Boxer LA, Hedley-Whyte ET, Stossel TP (1974) Neutrophil actin dysfunction and abnormal neutrophil behavior. New Engl J Med 291:1093

    PubMed  CAS  Google Scholar 

  28. Breton-Gorius J, Mason DY, Buriot D, Vilde JL, Griscelli C (1980) Lactoferrin deficiency as a consequence of a lack of specific granules in neutrophils from a patient with recurrent infections: detection by immunoperoxidase staining of lactoferrin and cytochemical electron microscopy. Amer J Path 99: 413

    PubMed  CAS  Google Scholar 

  29. Brown PK, Ophuls W (1902) A fatal case of acute primary infectious pharyngitis with extreme leukopenia. Amer Med 3:649

    Google Scholar 

  30. Bryan HG, Nixon RK (1965) Dyskeratosis congenita and familial pancytopenia. J Amer Med Assoc 192: 203

    CAS  Google Scholar 

  31. Burke V, Colebatch JH, Anderson CM, Simons MJ (1967) Association of pancreatic insufficiency and chronic neutropenia in childhood. Arch Dis Child 42:147

    PubMed  CAS  Google Scholar 

  32. Burchardt K, Zawilska K (1972) Benign familial neutropenia with deficiency of alkaline phosphatase in granulocytes. Pol Arch Med Wewn 49: 486

    Google Scholar 

  33. Carper HA, Hoffman PL (1966) The intravascular survival of transfused canine Pelger-Huet neurophils and eosinophils. Blood 27:739

    PubMed  CAS  Google Scholar 

  34. Cartwright GE, Hui-Lan Chung, An Chang (1948) Studies on the pancytopenia of kala-azar. Blood 3: 249

    PubMed  CAS  Google Scholar 

  35. Chédiak M (1952) Nouvelle anomalie leucocytaire de caractére constitutionel et familial. Rev Hémat 7: 362

    PubMed  Google Scholar 

  36. Clark RA, Kimball HR (1971) Defective granulocyte chemotaxis in the Chédiak-Higashi syndrome. J clin Invest 50: 2645

    PubMed  CAS  Google Scholar 

  37. Clark RA, Root RK, Kimball HR, Kirkpatrick CH (1973) Defective neutrophil chemotaxis and cellular immunity in a child with recurrent infections. Ann intern Med 78: 515

    PubMed  CAS  Google Scholar 

  38. Cline MJ (1977) Cellular kinetics of monocytes and macrophages. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology. McGraw-Hill, New York, p 869

    Google Scholar 

  39. Copeland GD, von Capeller D, Stem TN (1958) Systemic lupus erythematosus: A clinical report of 47 cases with pathological findings. Amer J Med Sei 236: 318

    CAS  Google Scholar 

  40. Cronkite EP, Fliedner TM (1964) Granulocytopoiesis. New Engl J Med 270:1347

    PubMed  CAS  Google Scholar 

  41. Cyr WL, Johnson H, Balfour J (1973) Granulomatous cystitis as a manifestation of chronic granulomatous disease of childhood. J Urol 110: 357

    PubMed  CAS  Google Scholar 

  42. Dale DC, Graw RG (1974) Transplantation of allogeneic bone marrow in canine cyclic neutropenia. Science 183: 83

    PubMed  CAS  Google Scholar 

  43. Dameshek W (1931) The appearance of histiocytes in the peripheral blood. Arch intern Med 47: 968

    Google Scholar 

  44. Danaraj TJ (1958) The treatment of eosinophilic lung (tropical eosinophilia) with diethylcarbamazine. Quart J Med 27: 243

    PubMed  CAS  Google Scholar 

  45. Dannenberg AM, Suga M, Garcia-Gonzales JE (1981) Macrophage in granulomas: Histochemical evidence suggesting local control of heterogeneous functions. In: Schmalzl F, Huhn D, Schaefer H-E (eds) Disorders of the monocyte macrophage system. Springer, Berlin Heidelberg New York, p 109

    Google Scholar 

  46. Darling RC, Parker F, Jackson H (1936) The pathological changes in the bone marrow in agranulocytosis. Amer J Path 12:1

    PubMed  CAS  Google Scholar 

  47. Davidson WM, Smith DR (1954) A morphological sex difference in polymorphonuclear neutrophil leucocytes. Brit Med J IV: 4878

    Google Scholar 

  48. Davidson WM, Milner RDG, Lawler SD (1960) Giant neutrophil leukocytes: an inherited anomaly. Brit J Haemat 6: 399

    Google Scholar 

  49. Davis SD, SchallerJ, Wedgwood RJ (1966) Job’s syndrome: Recurrent „cold” staphylococcal abszesses. Lancet I:1013

    Google Scholar 

  50. Döhle H (1911) Leukozyteneinschlüsse bei Scharlach. Zbl Bakteriol 61:63

    Google Scholar 

  51. Donohugh DL (1963) Tropical eosinophilia: An etiologic inquiry. New Engl J Med 269:1357

    PubMed  CAS  Google Scholar 

  52. Edwin E (1967) The segmentation of polymorphonuclear neutrophils. Acta med scand 182:1

    Google Scholar 

  53. Edwin E (1969) The segmentation of polymorphonuclear neutrophils in rheumatoid arthritis and ankylosing spondylitis. Acta rheum scand 15:121

    PubMed  CAS  Google Scholar 

  54. Engle RL, Koprowska J (1959) The appearance of histiocytes in the blood in subacute bacterial endocarditis. Amer J Med 26: 965

    PubMed  Google Scholar 

  55. Fanconi G (1941) Benigne chronische Agranulozytopenie beim Säugling. Ann paediat (Basel) 157: 317

    Google Scholar 

  56. Farquhar JW, Mac Gregor A, Richmond J (1958) Familial hemophagocytic reticulosis. Brit Med J 2:1561

    PubMed  CAS  Google Scholar 

  57. Finch SC (1977) Granulocytopenia. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology, 2nd edn. Mac Graw-Hill, New York, p 717

    Google Scholar 

  58. Finch SC (1977) Granulocytosis. In: Williams WJ, Beutler E, Ersles AJ, Rundles RW (eds) Hematology, 2nd edn. Mac Graw-Hill, New York, p 746

    Google Scholar 

  59. Fischer R, Schaefer HE (1971) Zur pathologischen Anatomie der Panmyelopathie und des Hypersplenismus. Internist 12: 151

    PubMed  CAS  Google Scholar 

  60. Fontan G, Lorente F, Garcia Rodriguez MC, Ojeda JA (1976) Defective neutrophil chemotaxis and hyperimmunglobulinemia E-a reversible defect? Acta paediatr Scand 65: 509

    PubMed  CAS  Google Scholar 

  61. Fraumeni JF (1967) Bone marrow depression induced by chloramphenicol or phenylbutazone: Leukemia and other sequelae. J Amer Med Assoc 201: 828

    Google Scholar 

  62. Gänsslen M (1941) Konstitutionelle familiäre Leukopenie (Neutropenie). Klin Wschr 20: 922

    Google Scholar 

  63. Gasser C (1952) Die Pathogenese der essentiellen chronischen Granulocytopenie im Kindesalter aufgrund der Knochenmarksbefunde. Helv paediatr Acta 7: 426

    PubMed  CAS  Google Scholar 

  64. Gilman PA, Jackson DP, Guild KG (1969) Congenital agranulocytosis: Prolonged survival and terminal acute leukemia. Blood 34:827

    Google Scholar 

  65. Glass DN, Fearon DT, Austen KF (1983) Inherited abnormalities of the complement system. In: Stanbury JB, Wyngaard-en JB, Fredrickson DS, Goldstein JL, Brown MS (eds) The metabolic basis of inherited disease, 5th edn. Mac Graw-Hill, New York, p 1934

    Google Scholar 

  66. Golde DW (1975) Disorders of mononuclear phagocyte proliferation, maturation, and function. Clin Haematol 4: 705

    PubMed  CAS  Google Scholar 

  67. Golde DW, Cline MJ (1977) Production, distribution, and fate of granulocytes. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology. Mac Graw-Hill, New York, p 698

    Google Scholar 

  68. Good RA, Zack SJ (1956) Disturbances in gamma globulin synthesis as „experiments of nature”. Pediatrics 18:109

    PubMed  CAS  Google Scholar 

  69. Gordin R (1952) Toxic granulation in leukocytes. Acta Med scand Suppl 270

    Google Scholar 

  70. Goudsmit R, v Leeuwen AM, James J (1971) Döhle bodies and acute leukaemia in one family: a new familial disorder? Brit J Haemat 20: 557

    PubMed  CAS  Google Scholar 

  71. Grić VZ, KalafaticZ (1958) Drei Fälle von inkompletter Alder-Anomalie. Schweiz Med Wschr 88: 994

    Google Scholar 

  72. Grignaschi VJ, Sperperato AM, Etcheverry MJ (1963) Un nuevo cadro citoquimico: negatividad espontanea de las reacciones de peroxidasas, oxidasas y lipido en la neutrofila y en los monocitos de dos hermanos. Rev Assoc Med Argent 77: 218

    Google Scholar 

  73. Groover RV, Burke EC, Gordon H, Berdon WE (1972) The genetic mucopolysaccharidoses. Semin Hemat 9: 371

    PubMed  CAS  Google Scholar 

  74. Hall JW, Kozak M, Spink WW (1964) Pulmonary infiltrates, pericorditis and eosinophilia. Amer J Med 36: 135

    PubMed  CAS  Google Scholar 

  75. Hahneman BM, Alt HL (1958) Cyclic neutropenia in a father and daughter. J Amer Med Assoc 168: 270

    CAS  Google Scholar 

  76. Hansson H, Linell F, Nilsson LR, Söderhjelm L, Undritz E (1959) Die Chédiak-Steinbrinck-Anomalie resp. erblich konstitutionelle Riesengranulation (Granulagiganten) der Leukozyten in Nordschweden. Folia haemat., Neue Folge 3:152

    CAS  Google Scholar 

  77. Hardy WR, Anderson RE (1968) Hypereosinophilic syndromes. Ann intern Med 68:1220

    PubMed  CAS  Google Scholar 

  78. Hargraves MM, Richmond H, Morton R (1948) Presentation of two bone marrow elements: the „Tart” cell and the „LE” cell. Proc Staff Meet Mayo Clin 23: 25

    PubMed  CAS  Google Scholar 

  79. Hargraves MM (1969) The discovery of the L. E. cell and its morphology. Mayo Clin Proc 44: 579

    PubMed  CAS  Google Scholar 

  80. Harm H (1952) Beiträge zur Morphologie und Genetik der Pelger-Anomalie bei Mensch und Kaninchen. Z menschl Vereb Konstitutionslehre 30: 501

    Google Scholar 

  81. Hartl W (1965) Drug allergic agranulocytosis (Schultz’s disease). Semin Hemat 2: 313

    PubMed  CAS  Google Scholar 

  82. Hegglin R, Gross R, LöhrGW (1964) Anomalie Hegglin-May (polyphyle Reifungsstörung). Schweiz Med Wschr 94:1357

    PubMed  CAS  Google Scholar 

  83. Hegglin R (1945) Gleichzeitige konstitutionelle Veränderungen an Neutrophilen und Thrombozyten. Helv Med Acta 12:439

    PubMed  CAS  Google Scholar 

  84. Heinivaara O, Kaipainen WJ (1961) Pelger-Huët anomaly in lymphocytic leukaemia. Acta haemat 25: 375

    PubMed  CAS  Google Scholar 

  85. Heller P, Zimmermann HJ (1956) Nucleophagocytosis: studies on three hundred thirty-six patients: review of incidence of L. E. phenomenon and allied conditions. Arch intern Med 97: 403

    CAS  Google Scholar 

  86. Herring WB, Smith LG, Walker RJ, Herion JC (1974) Hereditary neutrophilia. Amer J Med 56: 729

    PubMed  CAS  Google Scholar 

  87. Higashi O (1954) Congenital gigantism of peroxidase granules. Tohoku J exper Med 59: 315

    CAS  Google Scholar 

  88. Hill HR, Quie PG (1974) Raised serum IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet I: 183

    Google Scholar 

  89. Hill HR, Ochs HD, Quie PG, Clark RA, Pabst HF, Klebanoff SJ, Wedgwood RJ (1974) Defect in neutrophil granulocyte chemotaxis in Job’s syndrome of recurrent “cold” staphylococcal abszesses. Lancet II: 617

    Google Scholar 

  90. Hill RW, Bayrd ED (1960) Phagocytic reticuloendothelial cells in subacute bacterial endocarditis with negative cultures. Ann intern Med 52: 310

    PubMed  CAS  Google Scholar 

  91. Hittmair A, Leibetseder F (1958) Fälle von Pelger-Huëtscher Kemanomalie in Tirol. Schweiz Med Wschr 88:1004

    PubMed  CAS  Google Scholar 

  92. Hitzig WH (1959) Familiäre Neutropenie mit dominantem Erbgang und Hypergammaglobulinämie. Helv Med Acta 26:779

    PubMed  CAS  Google Scholar 

  93. Hofmann C, Braun-Falco O, Petzoldt D (1976) Akute febrile neutrophile Dermatose (Sweet-Syndrom). Dtsch Med Wschr 101:1113

    PubMed  CAS  Google Scholar 

  94. Hong R, Schubert WK, Perrin EV, West CD (1962) Antibody deficiency syndrome associated with beta-2-macroglobulinemia. J Pediatr 61: 831

    PubMed  CAS  Google Scholar 

  95. Huber H (1939) Stammbaumuntersuchungen bei Panmyelophthisekranken. Klin Wschr 18:1145

    Google Scholar 

  96. Huët GJ (1932) Über eine bisher unbekannte familiäre Anomalie der Leukozyten. Klin Wschr 11:1264

    Google Scholar 

  97. Ingraham LM, Bums CP, Boxer LA, Baehner RL, Haak RA (1981) Fluidity properties and lipid composition of erythrocyte membranes in Chediak-Higashi syndrome. J Cell Biol 89: 510

    PubMed  CAS  Google Scholar 

  98. Isaacson NH, Rapoport P (1946) Eosinophilia in malignant tumors: Its significance. Ann intern Med 25: 893

    PubMed  CAS  Google Scholar 

  99. Itoga T, Laszlo J (1962) Döhle bodies and other granulocytic alterations with cyclophosphamide. Blood 20: 668

    PubMed  CAS  Google Scholar 

  100. Ishizaka K, Ishizaka T (1970) The significance of immunoglobulin E in reagenic hypersensitivity. Ann Allergy 28:189

    PubMed  CAS  Google Scholar 

  101. Jeunet F, Good RA (1968) Thymoma, immunologic deficiencies, and hematological abnormalities. In: Good RA, Bergsma D (eds) Immunologic deficiency diseases in man, Vol 4. National Foundation Press, New York, p 192

    Google Scholar 

  102. Jewis EH, Takenchi A, Dillon DE, Ruymann FB, Rivken S (1971) The May-Hegglin anomaly: ultrastructure of the granulocyte inclusion. Amer J clin Path 55:187

    Google Scholar 

  103. Jones JB, Lange RD, Yang TJ, Vodopick H, Jones ES (1975) Canine cyclic neutropenia: Erythropoietin and platelet cycles after bone marrow transplantation. Blood 45: 213

    PubMed  CAS  Google Scholar 

  104. Jordans GHW (1947) Hereditary granulation anomaly of the leucocytes (Alder). Acta Med Scand 129: 348

    PubMed  CAS  Google Scholar 

  105. Jordan SE, Larsen WE (1965) Ultrastructure studies of the May-Hegglin anomaly. Blood 25: 921

    PubMed  CAS  Google Scholar 

  106. Juhlin L (1963) Basophil and eosinophil leukocytes in various disorders. Acta Med Scand 174: 249

    PubMed  CAS  Google Scholar 

  107. Kaplan JM, Barrett O (1967) Reversible pseudo-Pelger anomaly related to sulfisoxazole therapy. New Engl J Med 277: 421

    PubMed  CAS  Google Scholar 

  108. Kaplow LS (1975) Cytochemical heterogeneity of human circulating monocytes. Acta Cytologica 19: 358

    PubMed  CAS  Google Scholar 

  109. Kauer GL, Engle RL (1964) Eosinophilic leukaemia with Ph1-positive cells. Lancet II: 1340

    Google Scholar 

  110. Kay AB (1974) The eosinophil in infectious diseases. J infect Dis 129: 606

    PubMed  CAS  Google Scholar 

  111. Knicker WT, Panos TC (1957) Idiopathic infantile agranulocytosis with hypergammaglobulinaemia. Amer J Dis Child 94: 549

    Google Scholar 

  112. Killman SA (1957) Leukocyte agglutinins in collagen disease. Acta rheum scand 3: 209

    CAS  Google Scholar 

  113. Klebanoff SJ (1968) Myeloperoxidase-halide-hydrogen peroxide antibacterial system. J Bacteriol 95: 2131

    PubMed  CAS  Google Scholar 

  114. Klebanoff SJ, Clem WH, Luebke RG (1966) The peroxide-thio-cyanate-hydrogen peroxide antimicrobial system. Biochim bio-phys Acta 117: 63

    CAS  Google Scholar 

  115. Kostmann R (1956) Infantile genetic agranulocytosis. Acta paediat 45, Suppl 105: 1

    Google Scholar 

  116. Koszewski BJ, Vahabzedeh H, Willrodt BS (1967) Hemosiderin content of leukocytes in animals and in man and its significance in the physiology of granulocytes. Amer J clin Path 48: 474

    CAS  Google Scholar 

  117. Kracke RR (1931) Recurrent agranulocytosis. Amer J clin Path 1:385

    Google Scholar 

  118. Krill CE, Smith HD, Mauer AM (1964) Chronic idiopathic granulocytopenia. New Engl J Med 270: 973

    PubMed  Google Scholar 

  119. Lalezari P, Murphy GB, Allen FH (1971) NB1, a new neutrophil-specific antigen involved in the pathogenesis of neonatal neutropenia. J clin Invest 50:1108

    PubMed  CAS  Google Scholar 

  120. Lalezari P, Radel H (1974) Neutrophil specific antigens: Immunology and clinical significance. Semin Hemat 11: 281

    PubMed  CAS  Google Scholar 

  121. Landing BH, Shirkey HS (1957) Syndrome of recurrent infection and infiltration of viscera by pigmented lipid histiocytes. Pediatrics 20: 431

    PubMed  CAS  Google Scholar 

  122. Leader RW, Padgett GA, Gorham JR (1963) Studies of abnormal leukocyte bodies in the mink. Blood 22: 477

    PubMed  CAS  Google Scholar 

  123. Leale M (1910) Recurrent furunculosis in an infant showing an unusual blood picture. J Amer Med Assoc 54:1854

    Google Scholar 

  124. Leder LD (1971) Zytochemische Untersuchungen an Blutleukozyten beim Chediak-Higashi-Syndrom. Verhandl Dtsch Ges Path 55: 793

    Google Scholar 

  125. Levin DC (1967) The „P.I.E.” syndrome - pulmonary infiltrates with eosinophilia; a report of 3 cases with lung biopsy. Radiology 84: 461

    Google Scholar 

  126. Levine S (1959) Chronic familial neutropenia with marked periodontal lesions. Oral Surg 12: 310

    PubMed  CAS  Google Scholar 

  127. Lin YK (1973) Leukopenia in alcoholics. Amer J Med 54: 605

    Google Scholar 

  128. Litt M (1964) Eosinophils and antigen-antibody reactions. Ann NY Acad Sei 116: 964

    CAS  Google Scholar 

  129. Lockie LM, Norcross BM, George CW (1947) Treatment of two reactions due to gold: Response of thrombocytopenic purpura and granulocytopenia to BAL therapy. J Amer Med Assoc 133:754

    CAS  Google Scholar 

  130. Löffler W (1936) Endocarditis parietalis fibroplastica mit Bluteosinophilie. Ein eigenartiges Krankheitsbild. Schweiz Med Wschr 66:817

    Google Scholar 

  131. Löffler W (1936) Die flüchtigen Lungeninfiltrate mit Eosinophilie. Schweiz Med Wschr 66: 1069

    Google Scholar 

  132. Lonsdale D, DeodharSD, Mercer RD (1967) Familial granulocytopenia and associated immunglobulin abnormality: Report of three cases in young brothers. J Pediatr 71: 790

    PubMed  CAS  Google Scholar 

  133. Louie JS, Pearson CM (1971) Felty’s syndrome. Semin Hematol 8:216

    PubMed  CAS  Google Scholar 

  134. Lübbers P, Koch E (1949) Leukocytäre Abbauformen im Blut bei entzündlichen Erkrankungen. Klin Wschr 25/26: 442

    Google Scholar 

  135. Lüers T (1956) Ein morphologisches Geschlechtsmerkmal in Leukocytenkemen. Berl Med 7:120

    Google Scholar 

  136. Lüers VT (1960) Das numerische Verhalten der geschlechtsspezifischen Kemanhänge bei der erblich-konstitutionellen Hochsegmentierung der Neutrophilenkeme Undritz. Schweiz Med Wschr 90: 246

    Google Scholar 

  137. Luhby AL, Slobody L (1956) Transient neonatal agranulocytosis in two siblings: Transplacental isoimmunization to a leukocyte factor. Amer J Dis Child 92: 496

    Google Scholar 

  138. Lutzner MA, Lowrie ChT, Jordan HW (1967) Giant granules in leukocytes of the beige mouse. J Heredity 58: 299

    CAS  Google Scholar 

  139. Lux Se, Johnston RB, August CS, Say B, Penchaszadeh VB, Rosen FS, McKusick VA (1970) Neutropenia and abnormal cellular immunity in cartilage-hair hypoplasia. New Engl J Med 282:234

    Google Scholar 

  140. Major RH, Leger LH (1939) Marked eosinophilia in Hodgkin’s disease. J Amer Med Asso 112: 2601

    Google Scholar 

  141. Maldonado JE, Hanlon DG (1965) Monocytosis: a current appraisal. Mayo Clin Proc 40: 248

    PubMed  CAS  Google Scholar 

  142. Marsh JC, Boggs DR, Cartwright Ge, Wintrobe MM (1967) Neutrophil kinetics in acute infection. J clin Invest 46: 1943

    PubMed  CAS  Google Scholar 

  143. Masina N (1932) Das Blutbild bei Leberzirrhose mit besonderer Berücksichtigung der Monozytengranulation. Folia haematol 46:335

    Google Scholar 

  144. Matsaniotis N, Kiossoglou KA, Karpuzas J, Anastasea-Vlachou K (1966) Chromosomes in Kostmann’s disease. Lancet II: 104

    Google Scholar 

  145. May R (1909) Leukozyten-Einschlüsse. Arch klin Med 96:1

    Google Scholar 

  146. McCall CE, Katayamal, Cotran RS, Finland M (1969) Lysosomal and ultrastructural changes in human „toxic” neutrophils during bacterial infection. J exper Med 129: 267

    CAS  Google Scholar 

  147. McCall CE, Caves J, Cooper R, DeChatelet L (1971) Functional characteristics of human toxic neutrophils. J infect Dis 124: 68

    PubMed  CAS  Google Scholar 

  148. McCall CE, DeChatelet LR, Cooper MR, Shannon C (1973) Human toxic neutrophils. III. Metabolic characteristics. J infect Dis 127: 26

    PubMed  CAS  Google Scholar 

  149. McKusick V (1983) Mendelian inheritance in man. The John Hopkins University Press, 6th edt. Baltimore

    Google Scholar 

  150. Meuret G, FliednerTM (1970) Zellkinetik der Granulopoese und des Neutrophilensystems bei einem Fall von zyklischer Neutropenie. Acta haemat (Basel) 53: 48

    Google Scholar 

  151. Miale JB (1982) Laboratory Medicine Hematology. Mosby, 6th edt. St. Louis

    Google Scholar 

  152. Miller ME, Oski FA, Harris MB (1971) Lazy-leukocyte syndrome. A new disorder of neutrophil function. Lancet I: 665

    Google Scholar 

  153. Miller ME, Norman ME, Koblenzer PJ, SchonauerT (1973) A new familial defect of neutrophil movement. J lab clin Med 82: 1

    PubMed  CAS  Google Scholar 

  154. Miller ME (1975) Pathology of chemotaxis and random mobility. Semin Hematol 12: 59

    PubMed  CAS  Google Scholar 

  155. Moeschlin S, Wagner K (1952) Agranulocytosis due to the occurrence of leukocyte-agglutinins (Pyramidon and cold agglutinins). Acta haemat 8: 29

    PubMed  CAS  Google Scholar 

  156. Moran TJ, Estevez JM (1969) Chediak-Higashi disease. Morphologic studies of a patient and her family. Arch Path 88: 329

    PubMed  CAS  Google Scholar 

  157. Morley AA, Carew JP, Baikie AG (1967) Familial cyclical neutropenia. Brit J Haemat 13: 719

    PubMed  CAS  Google Scholar 

  158. Musser JH (1921) The leukocytes after hemorrhages. Amer J med Sei 162:40

    Google Scholar 

  159. Nachtsheimer H (1950) The Pelger-anomaly in man and rabbit; mendelian character of the nuclei of the leucocytes. J Hered 41: 131

    Google Scholar 

  160. Naiman JL, Oski FA, Allen FH, Diamond LK (1964) Hereditary eosinophilia: Report of a family and review of the literature. Amer J human Genet 16: 195

    CAS  Google Scholar 

  161. Nichols BA, Bainton DF, Farquhar MG (1971) Differentiation of monocytes. Origin, nature and fate of their azurophil granules. J Cell Biol 50: 498

    PubMed  CAS  Google Scholar 

  162. Ochs HD, Davis SD, Mickelson E, Lemer KG, Wedgewood RJ (1974) Combined immundeficiency and reticuloendotheliosis with eosinophilia. J Pediatr 85: 463

    PubMed  CAS  Google Scholar 

  163. Oliver MJ, Krawiec JA, Berlin RD (1976) Carbamylcholine prevents giant granule formation in cultured fibroblasts from beige (Chediak-Higashi) mice. J Cell Biol 69: 205

    PubMed  CAS  Google Scholar 

  164. Padgett GA, Leader RW, Gorham JR, O’Mary CC (1964) The familial occurrence of the Chediak-Higashi syndrome in the mink and cattle. Genetics 49: 505

    PubMed  CAS  Google Scholar 

  165. Payne R (1962) The development and persistence of leukoag-glutinins in parous women. Blood 19: 411

    PubMed  CAS  Google Scholar 

  166. Pearson HA, Lorincz AE (1964) A characteristic bone marrow finding in Horber syndrome. Pediatrics 34: 281

    Google Scholar 

  167. Pelger K (1928) Demonstratie van den paar zeldzaam voorkom-mende typen van vloedlichchaampges en bespreking der patienten. Ned T Geneesk 72: 1178

    Google Scholar 

  168. Pinkerton PH, Robinson JB, Senn JS (1978) Lazy leucocyte syndrome-disorder of the granulocyte membrane? J clin Pathol 31: 300

    PubMed  CAS  Google Scholar 

  169. Pisciotta AV, Ebbe SN, Lennon ES, Metzger GO, Madison FW (1958) Agranulocytosis following administration of phenothiazine derivates. Amer J Med 15: 210

    Google Scholar 

  170. Pisciotta AV (1969) Agranulocytosis induced by certain phenothiazine derivates. J Amer Med Assoc 208:1862

    CAS  Google Scholar 

  171. Plum P (1937) Clinical and experimental investigations in agranulocytosis. HK Lewis & Co Ltd, London

    Google Scholar 

  172. Presentey BZ (1968) A new anomaly of eosinophilic granulocytes. Amer J clin Path 49: 887

    Google Scholar 

  173. Redies H, Quenzer K, Tolksdorf M, Saile ML, Wiedemann HR (1958) Über die Häufigkeit der Pelger-Anomalie. Schweiz Med Wschr 88:1002

    PubMed  CAS  Google Scholar 

  174. Reed RJ, Terazaki N (1972) Subcutaneous angioblastic lymphoid hyperplasia with eosinophilia (Kimura’s disease). Cancer 29:489

    PubMed  CAS  Google Scholar 

  175. Reilly WA (1941) The granules in the leukocytes in gargoylism. Amer J Dis Child 62: 489

    Google Scholar 

  176. Rodin AE, Haggord ME, Nichols MM, Gustaussen LP (1973) Infantile genetic agranulocytosis: Two cases occurring in siblings and one in a distant relative. Amer J Dis Child 126: 818

    PubMed  CAS  Google Scholar 

  177. Rohr K (1939) Der heutige Stand der Agranulozytoseforschung. Helv Med Acta 6: 611

    Google Scholar 

  178. Rosenthal N, Abel HA (1936) The significance of the monocytes in agranulocytosis (leukopenic infectious monocytosis). Amer J clin Path 6: 205

    Google Scholar 

  179. Ruscetti R, Cypress R, Chorvenick P (1975) Specific release of neutrophil and eosinophil stimulating factors from sensitized lymphocytes. Clin Res 23: 406 A

    Google Scholar 

  180. Salomon SE, Cline MJ, Schultz J, Lehrer RL (1970) Myeoloper-oxidase deficiency. Immunologic study of a genetic leukocyte defect. New Engl J Med 282: 250

    Google Scholar 

  181. Savilahti M (1956) Mehr als 100 Vergiftungsfälle durch Benzol in einer Schuhfabrik. Arch Gewerbepath Gewerbehyg 15: 147

    CAS  Google Scholar 

  182. Schaefer HE, Weller P, Lansch D (1983) Erworbene und ererbte Defektformen der granulozytären Peroxidase (POX). Acta histochem, Suppl XXVIII: 219

    Google Scholar 

  183. Schäli H (1964) Die erblich-konstitutionelle Hochsegmentierung der Kerne der neutrophilen Leukozyten im Rahmen der humanen und der vergleichenden Haematologie. Inaug Diss, Basel

    Google Scholar 

  184. Schilling V (1951) Periodisch-rezidivierende Neutropenie mit Monocytose. II Haematologie der periodischen Neutropenie; ihre Bedeutung für die Monocytogenese und den Trialismus der Monocyten. Folia haemat 70: 1

    Google Scholar 

  185. Schneiderman LY, Sampson WJ, Schoene WC, Haydon GB (1969) Genetic studies of a family with two unusual autosomal dominant conditions: muscular dystrophy and Pelger-Huet anomaly. Clinical, pathologic and linkage considerations. Amer J Med 46:380

    PubMed  CAS  Google Scholar 

  186. Schultz W (1922) Über eigenartige Halserkrankungen. Dtsch Med Wschr 48: 1495

    Google Scholar 

  187. Schwachman H, Diamond LK, Oski FA, Khaw KT (1964) The syndrome of pancreatic insufficiency and bone marrow dysfunction. J Pediatr 65: 645

    Google Scholar 

  188. Sears WG (1932) The blood in Hodgkin’s disease, with special reference to eosinophilia. Guy’s Hosp. Rep 82: 40

    Google Scholar 

  189. Shanbrom E, Tanaka KR (1962) Acquired Pelger-Huet granulocytes in severe myxedema. Acta haemat 27: 289

    PubMed  CAS  Google Scholar 

  190. Shelley WB, Pames HM (1965) The absolute basophile count: Technique and significance. J Amer Med Assoc 192: 368

    CAS  Google Scholar 

  191. Steinbrinck W (1948) Über eine neue Granulationsanomalie der Leukozyten. Dtsch Arch klin Med 193: 577

    Google Scholar 

  192. Stobbe H, Jorke D (1965) Befunde an homozygoten Pelger-Merkmalsträgem. Schweiz Med Wschr 95: 1529

    Google Scholar 

  193. Stone GE, Redmond AJ (1963) Leukopenie infectious monocytosis. Amer J Med 34: 541

    PubMed  CAS  Google Scholar 

  194. Stossel TP, Boxer LA (1977) Qualitative abnormalities of granulocytes. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds). McGraw-Hill, New York, p 756

    Google Scholar 

  195. Straus DJ (1973) Hematologic aspects of alcoholism. Semin Hematol 10:183

    PubMed  CAS  Google Scholar 

  196. Strauss RG, Bove KE, Jones JF, Mauer AM, Fulginiti NA (1974) An anomaly of neutrophil morphology with impaired function. New Engl J Med 290:478

    PubMed  CAS  Google Scholar 

  197. Sty JR, Chusid MJ, Babbitt DP, Werlin SL (1979) Involvement of the colon in chronic granulomatous disease of childhood. Radiology 132:618

    PubMed  CAS  Google Scholar 

  198. Sullivan AL, Grimley PM, Metzger H (1971) Electron microscopic localization of immunoglobulin E on the surface membrane of human basophils. J exp Med 134:1403

    PubMed  CAS  Google Scholar 

  199. Sweet RD (1964) An acute febrile neutrophilic dermatosis. Brit J Dermatol 76:394

    Google Scholar 

  200. Taylor RE, Farrell RK (1973) Light and electron microscopy of peripheral blood neutrophiles in a killer whale affected with Chediak-Higashi-Syndrome. Fed Proc 32:822

    Google Scholar 

  201. Trentham DE, Masi AT, Bale GF (1976) Arthritis with an inflammatory dermatosis resembling Sweet’s syndrome. Report of a unique case and review of the literature on arthritis associated with inflammatory dermatoses. Amer J Med 61:424

    PubMed  CAS  Google Scholar 

  202. Türk W (1907) Septische Erkrankungen bei Verkümmerung des Granulocytensystems. Wien klin Wschr 20:157

    Google Scholar 

  203. Twomey JJ, Leavell BS (1965) Leukemoid reactions to tuberculosis. Arch intern Med 116:21

    PubMed  CAS  Google Scholar 

  204. Uchida T, Kariyone S (1973) Intravascular granulocyte kinetics and spleen size in patients with chronic benign neutropenia of childhood

    Google Scholar 

  205. Undritz E, de Sepilus C (1957) Results of recent examination of a family from Wallis, in which was found 25 years ago the first Swiss case of Pelger-Huëtscher nuclear anomaly: Present states of studies on this abnormality. Schweiz Med Wschr 87: 1258

    PubMed  CAS  Google Scholar 

  206. Undritz E (1958) Eine neue Sippe mit erblich-konstitutioneller Hochsegmentierung der Neutrophilenkeme. Schweiz Med Wschr 88: 1000

    PubMed  CAS  Google Scholar 

  207. Undritz E, Schäli H (1964) Eine neue Sippe mit erblich-konstitutioneller Hochsegmentierung der Neutrophilenkeme und das Knochenmarkbild beim homozygoten Träger dieser Anomalie. Schweiz Med Wschr 94:1365

    PubMed  CAS  Google Scholar 

  208. de Vaal OM, Seynhaeve V (1959) Reticular dysgenesia. Lancet II: 1123

    Google Scholar 

  209. Weening RS, Schooreil EP, Roos D, van Schaik MU, Voetman AA, Bot AAM, Batenburg-Plenter AM, Willems C, Zeijle-maker WP, AstaldiA (1981) Effect of ascorbate on abnormal neutrophil, platelet, and lymphocyte function in a patient with the Chediak-Higashi syndrome. Blood 57:856

    PubMed  CAS  Google Scholar 

  210. Weil P (1922) Études sur les leucocytes. II. Les corpuscules basophiles des leucocytes neutrophiles. Arch d’Anat microscop 18:46

    Google Scholar 

  211. Weiner W, Topley E (1955) Döhle bodies in the leucocytes of patients with bums. J clin Path 8: 324

    PubMed  CAS  Google Scholar 

  212. Weisman G (1972) Lysosomal mechanisms of tissue injury in arthritis. New Engl J Med 286:141

    Google Scholar 

  213. White JG (1973) The Chediak-Higashi syndrome. Fine structure of giant inclusions in freeze-fractured neutrophils. Amer J Path 72:503

    PubMed  CAS  Google Scholar 

  214. Windhorst DB, Good RA (1971) Dermatologie manifestations of fatal granulomatous disease of childhood. Arch Dermatol 103:351

    PubMed  CAS  Google Scholar 

  215. Wolfson JJ, Kane WJ, Laxdal SD, Good RA, Quie PG (1969) Bone findings in chronic granulomatous disease of childhood. J Bone Joint Surg 51:1573

    PubMed  CAS  Google Scholar 

  216. Young AK, Middleton RG (1980) Urologie manifestation of chronic granulomatous disease. J Urol 123:119

    PubMed  CAS  Google Scholar 

  217. Yunis AA, Bloomberg GR (1964) Chloramphenicol toxicity: Clinical features and pathogenesis. Prog Hematol 4:138

    PubMed  CAS  Google Scholar 

  218. Zeni G, Nardi F, Frezza M (1964) In tema di ipereosinofilia constituzionale familiale idiopatica. Acta Med Patav 24: 589

    Google Scholar 

  219. Zieve PD, Haghshenass M, Blanks M, Krevans JR (1966) Vacuolization of the neutrophil. An aid in the diagnosis of septicemia. Arch intern Med 118: 356

    PubMed  CAS  Google Scholar 

  220. Zuelzer WW, Bajoghli M (1964) Chronic granulocytopenia in childhood. Blood 23:359

    PubMed  CAS  Google Scholar 

  221. Zuelzer WW (1964) „Myelokathexis” - a new form of chronic granulocytopenie. New Engl J Med 270: 699

    PubMed  CAS  Google Scholar 

Literatur

  1. Bessis M (1972) Cellules du sang normal et pathologique. Masson et Cie, Paris

    Google Scholar 

  2. Queißer W (ed) (1978) Das Knochenmark. Morphologie, Funktion, Diagnostik. Thieme, Stuttgart

    Google Scholar 

  3. Rappaport H (1963) Tumors of the hematopoietic system. In: Atlas of tumor pathology, Section III-Fascicle 8. Armed Forces Institute of Pathology, Washington

    Google Scholar 

  4. Rywlin AM (1976) Histopathology of the bone marrow, 1st edn. Little Brown and Co (Inc)

    Google Scholar 

  5. Sagher F, Even-Paz Z (1967) Mastocytosis and the mast cell. Karger, Basel

    Google Scholar 

  6. Williams WJ, Beutler E, Erslev AJ, Rundles RW (1977) Hematology, 2nd edn. McGraw-Hill, New York

    Google Scholar 

  7. Wintrobe MM, Lee GR, Boggs DR, Bithell TC, Athens JW, Foerster J (1974) Clinical Hematology, 7th edn. Lea & Febiger, Philadelphia

    Google Scholar 

  8. Abe S, Sandberg AA (1979) Chromosomes and causation of human cancer and leukemia. XXXII. Unusual features of Ph1-positive acute myeloblastic leukemia (AML), including a review of literature. Cancer 43: 2352

    PubMed  CAS  Google Scholar 

  9. Ackerman A, Grasso JA, Knouff RA (1960) Morphological and histochemical studies of leukemic cells from a patient with atypical myeloblastic leukemia with special reference to intracytoplasmic mucopolysaccharide vacuoles and fibrillar formation. Blood 16:1253

    PubMed  CAS  Google Scholar 

  10. Ackerman GA (1964) Eosinophilic leukemia. A morphologic and histochemical study. Blood 24: 372

    PubMed  CAS  Google Scholar 

  11. Albrecht M (1966) „Gaucher-Zellen” bei chronischer Myeloischer Leukämie. Blut 13:169

    PubMed  CAS  Google Scholar 

  12. Albrecht M (1972) Ergebnisse von Langzeitbeobachtungen bei Patienten mit chronisch myeloischer Leukämie. In: Gross R, van de Loo J (eds) Leukämie. Springer, Berlin Heidelberg New York, S 399–404

    Google Scholar 

  13. Anderson RE, Hoshino T, Yamamoto T (1964) Myelofibrosis with myeloid metaplasia in survivors of the atomic bomb. Ann Intern Med 60:1

    PubMed  CAS  Google Scholar 

  14. Aptuna E, Anteunis A, Kralik M, Astesano A, Robineaux R, Debray J (1978) Hairy cell leukemia. A clinical immunological and ultrastructural study. New data for the origin of the hairy cell. Virchows Arch B Cell Path 28:135

    Google Scholar 

  15. Arinkin MJ (1929) Intravitale Untersuchungsmethodik des Knochenmarks. Folia haematol 38: 233

    Google Scholar 

  16. Athens JW, Raab SO, Haab OP, Boggs DR, Ashenbrucker J, Catwright GE, Wintrobe MM (1965) Leukokinetic studies. X. Blood granulocyte kinetics in chronic myelocytic leukemia. J clin Invest 44: 765

    PubMed  CAS  Google Scholar 

  17. Auer J (1906) Some hitherto undescribed structures in the large lymphocytes in a case of acute leukaemia. Amer J med Sei 131: 1002

    Google Scholar 

  18. Baikie AG, Court Brown WM, Buckton KE, Hamden DG, Jacobs PA, Tough IM (1960) A possible specific chromosome abnormality in human chronic myeloid leukemia. Nature 188: 1165

    PubMed  CAS  Google Scholar 

  19. Bain BJ, Catovsky D, O’Brien M, Grant Prentice H, Lawlor E, Kumaran TO, McCann SR, Matutes E, Galton DAG (1981) Megakaryoblastic leukemia presenting as acute myelofibrosis. A study of four cases with a platelet-peroxidase-reaction. Blood 58:206

    PubMed  CAS  Google Scholar 

  20. Bainton D, Friedländer LM, Shohet SB (1977) Abnormalities in granule formation in acute myelogenous leukemia. Blood 49: 693

    PubMed  CAS  Google Scholar 

  21. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1976) Proposal for classification of acute leukaemias. Brit J Haemat 33: 451

    PubMed  CAS  Google Scholar 

  22. Benett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C (1981) The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlation. Brit J Haematol 47: 553

    Google Scholar 

  23. Bentley HP, Reardon AE, Knoedler JP, Krivit W (1961) Eosinophilic leukemia. Report of a case, with review and classification. Amer J Med 30: 310

    Google Scholar 

  24. Bernard J (1976) Preleukemic states. Blood Cells 2: 5

    Google Scholar 

  25. Bouroncle BA, Doan CA (1937) Myelofibrosis: Clinical hematologic and pathologic study of 110 patients. Amer J Med Sei 243:697

    Google Scholar 

  26. Bousser J (1957) Eosinophilie et leucemie. Sang 28:553

    PubMed  CAS  Google Scholar 

  27. Bozdech MJ, Bainton DF (1981) Identification of alpha-naphthyl butyrate esterase as a plasma membrane ectoenzyme of monocytes and as a discrete intracellular membrane-bounded organelle in lymphocytes. J exper Med 153: 182

    CAS  Google Scholar 

  28. Brady RO (1978) Glucosyl ceramide lipidosis: Gaucher’s disease. In: Stanbury JB, Wyngaarden JB, Fredrickson DS (eds) The metabolic basis of inherited disease, 4th edn. McGraw-Hill, New York, p 731

    Google Scholar 

  29. Braylan RC, Jaffe ES, Triche TJ, Nanba K, Fowlkes BJ, Metzger H, Frank MM, Dolan MS, Yee CL, Green I, Berard CW (1978) Structural and functional properties of the „hairy” cells of leukemic reticuloendotheliosis. Cancer 41: 210

    PubMed  CAS  Google Scholar 

  30. Breton-Gorius J, Coquin Y, Vilde JL, Dreyfus B (1976) Cytochemical and ultrastructural studies of aberrant granules in the neutrophils of two patients with myeloperoxidase deficiency during a preleukemic state. Blood Cells 2:187

    Google Scholar 

  31. Breton-Gorius J, Reyes F, Duhamel G, Najman A, Gorin NC (1978) Megakaryoblastic acute leukemia: Identification by the ultrastructural demonstration of platelet peroxidase. Blood 51: 45–60

    PubMed  CAS  Google Scholar 

  32. Burke SJ, Byme GE, Rappaport H (1974) Hairy cell leukemia (leukemic reticuloendotheliosis). I. A clinical pathologic study of 21 patients. Cancer 33:1399

    PubMed  CAS  Google Scholar 

  33. Burnet M (1958) Leukemia as a problem in preventive medicine. New Engl J Med 259: 423

    PubMed  CAS  Google Scholar 

  34. Court Brown WM, Abbatt JD (1955) The incidence of leukemia in ankylosing spondylitis treated with x-rays: A preliminary report. Lancet I:1283

    Google Scholar 

  35. Cutler SJ, Axteil L, Heise J (1967) Ten thousand cases of leukemia. J nat Cancer Inst 39: 993

    PubMed  CAS  Google Scholar 

  36. Dameshek W (1951) Some speculations on the myeloproliferative disorders. Blood 6: 372

    PubMed  CAS  Google Scholar 

  37. Dameshek W, Gunz F (1964) Leukemia, 2nd edn. Grune & Stratton, New York

    Google Scholar 

  38. Daniel MT, Flandrin G (1974) Fine structure of abnormal cells in hairy cell (tricholeukocytic) leukemia, with special reference to their in vitro phagocytic capacity. Lab Invest 30:1

    PubMed  CAS  Google Scholar 

  39. Darte JM, Dacie JV, McSorley JGA (1954) Pelger-like leucocytes in chronic myeloid leukemia. Acta haemat 12: 117

    PubMed  CAS  Google Scholar 

  40. Davidson WM, Knight LA (1973) Acquired trisomy 9. Lancet I: 1510

    Google Scholar 

  41. Delbeke MJ, Dacremont G (1972) Gaucher cells in chronic myelogenous leukemia. Acta paediatr belg 26: 70

    PubMed  CAS  Google Scholar 

  42. Didisheim P, Trombold JS, Vandervoot RLE, Songin MR (1964) Acute promyelocytic leukemia with fibrinogen and factor V deficiencies. Blood 23: 717

    PubMed  CAS  Google Scholar 

  43. Dietrich M, Rasche H, Kubanek B (1975) Coagulation disorder in acute leukemia as a prognostic factor. Adv Biosci 14: 175

    Google Scholar 

  44. Dittrich H (1952) Zur Frage der eosinophilen Leukämie. Acta haemat 7: 230

    PubMed  CAS  Google Scholar 

  45. Doan CA, Reinhardt HL (1941) The basophil granulocyte, basophilocytosis and myeloid leukemia, basophil and „mixed granule” types; an experimental, clinical and pathologic study with the report of a new syndrome. Amer J clin Pathol 11:1

    Google Scholar 

  46. Dosik H, Rosner F, Sawitzky A (1972) Acquired lipidosis: Gaucher-like cells and „blue cells” in chronic granulocytic leukemia. Sem Hemat 9: 309

    CAS  Google Scholar 

  47. Downey H (1934) Diseases of the Blood. In: Bell ET (ed) A Text-Book of Pathology, 2nd edn. Lea & Febiger, Philadelphia

    Google Scholar 

  48. Drings P (1978) Die chronische myeloische Leukämie. In: Queißer W (ed) Das Knochenmark. Morphologie-Funktion-Dia-gnostik. Thieme, Stuttgart, S 297

    Google Scholar 

  49. Düllmann J, Wulfhekel U, Großschupff G, Kühl M, Bartelt D, Hausmann K (1983) Die Haarzell-Leukämie. Zweiter Bericht zur Klinik, Morphologie und Therapie bei nunmehr 27 Patienten. Dtsch Med Wschr 108: 46

    PubMed  Google Scholar 

  50. Duhamel G (1971) Lymphoid myelofibrosis. About 10 further observations. Acta haemat 45: 85

    Google Scholar 

  51. Eagan JW, Baughman KL, Miller S, Conley CL, Eggleston JC (1977) Systemic mastocytosis in a patient with polycythemia vera treated with radioactive phosphorus. Blood 49: 563

    PubMed  Google Scholar 

  52. Ebstein W (1889) Über die akute Leukämie und Pseudoleukämie. Dtsch Arch klin Med 44: 343

    Google Scholar 

  53. Efrati P, Klajman A, Spitz H (1957) Mast cell leukemia? - Malignant mastocytosis with leukemia-like manifestations. Blood 12:869

    PubMed  CAS  Google Scholar 

  54. Ellis JM (1949) Urticaria pigmentosa. A report of a case with autopsy. Arch Pathol 48: 426

    CAS  Google Scholar 

  55. Emile-Weil P (1933) La leucémie myélogéne à polynucléaires neutrophiles. Sang 7: 445

    Google Scholar 

  56. Epstein E, Goedel A (1934) Hämorrhagische Thrombocythämie bei vasculärer Schrumpfmilz. Virchows Arch 292: 233

    Google Scholar 

  57. Fialkow PJ (1980) Clonal and stem cell origin of blood cell neoplasms. In: LoBue J (ed) Contemporary Hematology and Oncology, Vol 1. Plenum Press, New York, pp 1–46

    Google Scholar 

  58. Fischer R, Schmalzl F (1964) Über die Hemmbarkeit der Esteraseaktivität in Blutmonozyten durch Natriumfluorid. Klin Wschr 42:751

    PubMed  CAS  Google Scholar 

  59. Fischer R, Hennekeuser HH, Schaefer HE (1970) Extramedulläre Blutbildung in der Milz, insbesondere bei Knochenmetastasierung. In: Lennert K, Harms D (eds) Die Milz. Springer, Berlin Heidelberg New York, S 81–92

    Google Scholar 

  60. Fischer R, Schaefer HE (1972) Die pathologische Anatomie der Leukosen. In: Gross R, van de Loo J (eds) Leukämie. Springer, Berlin Heidelberg New York, S 1 –24

    Google Scholar 

  61. Fischer R, Schaefer HE (1976) Pathologisch-anatomische Befunde bei Leukämien und anderen myeloproliferativen Erkran-kungen. In: Stacher A, Höcker P (eds) Erkrankungen der Myelopoese. Urban und Schwarzenberg, München, S 42–46

    Google Scholar 

  62. Fischer R, Schaefer HE (1979) Präleukämien. Verhandl Dtsch Ges Path 63: 154

    Google Scholar 

  63. Fohlmeister I, Hellriegel KP, Schaefer HE, Fischer R (1978) Klinische und morphologische Beobachtungen bei einer partiell peroxydasedefekten, Ph1-positiven chronischen myelomonozytären Leukämie. Blut 37: 168

    Google Scholar 

  64. Fohlmeister I, Schaefer HE, Mödder B, Hellriegel KP, Fischer R (1981) Chronische lymphoproliferative Erkrankung unter dem Bilde einer Haarzell-Leukämie. Blut 42: 367

    PubMed  CAS  Google Scholar 

  65. Fohlmeister I, Schaefer HE, Fischer R (1982) On the pathogenesis of preleukemic myelodysplastic syndromes. Development of a dysplastic hemopoietic proliferation in the rat after a single pulse dose of dimethylbenz(a)-anthracene (DMBA). J Cancer Res clin Oncol 104: 249

    PubMed  CAS  Google Scholar 

  66. Frame B, Nixon RK (1968) Bone-marrow mast cells in osteoporosis of aging. New England J Med 279: 626

    CAS  Google Scholar 

  67. Freeman AI, Journey LJ (1971) Ultrastructural studies on monocytic leukaemia. Brit J Haematol 20: 225

    CAS  Google Scholar 

  68. Freeman HE, Koletsky S (1939) Cutaneous lesions in monocytic leukemia. Report of two cases, with pathologic study. Arch Dermatol Syphilis 40: 218

    Google Scholar 

  69. Freireich EJ, Thomas LB, Frei E, Fritz RD, Forkner CE (1960) A distinctive type of intracerebral hemorrhage associated with „blastic crisis” in patients with leukemia. Cancer 13: 146

    PubMed  CAS  Google Scholar 

  70. Friedreich N (1857) Ein neuer Fall von Leukämie. Virchows Arch Path Anat 12: 37

    Google Scholar 

  71. Galton DAG (1969) Chronic granulocytic leukemia. Semin Hemat 6: 323

    PubMed  CAS  Google Scholar 

  72. Garson OM, Milligan WJ (1972) The 45, XO, Ph1 subgroup of chronic granulocytic leukemia. Scand J Haematol 9:186

    PubMed  CAS  Google Scholar 

  73. Geary CG, Catovsky D, Wiltshaw E, Milner GR, Scholes MC, van Noorden S, Wadsworth LD, Muldal S, Maclver JE, Galton DAG (1975) Chronic myelomonocytic leukaemia. Brit J Haemat 30:289

    PubMed  CAS  Google Scholar 

  74. Georgii A, Vykoupil KF, Thiele J (1980) Chronic megakaryo-cytic granulocytic myelosis - CMGM. A subtype of chronic myeloid leukemia. Virchows Arch A Path Anat and Histol 389: 253

    CAS  Google Scholar 

  75. Golding PL, Green AE (1976) Blast-cell transformation chronic granulocytic leukaemia. Lancet II: 854

    Google Scholar 

  76. Golomb HM, Braylan R, Pollack A (1975) Hairy cell leukaemia (leukaemic reticuloendotheliosis): a scanning microscopic study of eight cases. Brit J Haemat 29: 455

    PubMed  CAS  Google Scholar 

  77. Gooi JHC, Bums GF, Cawley JC (1979) Hairy-cell leukaemia: an immunoperoxidase study of paraffin embedded tissues. J Clin Path 32:1244

    PubMed  CAS  Google Scholar 

  78. Graham DC (1960) Leukemic following x-ray therapy for ankylosing spondylitis. Arch intern Med 105: 51

    PubMed  CAS  Google Scholar 

  79. Gralnick HR, Marchesi S, Givelber H (1972) Intravascular coagulation in acute leukemia: Clinical and subclinical abnormalities. Blood 40: 709

    PubMed  CAS  Google Scholar 

  80. Gross R, Hellweg G, Lambers K (1955) Zur Frage der eosinophilen Leukämie. Z Kinderheilkunde 77: 208

    CAS  Google Scholar 

  81. Grouls V (1983) Die Haarzellen-Leukämie. Dtsch Ärzteblatt 47:31

    Google Scholar 

  82. Grieshammer W (1937) Beitrag zur sog. „Osteosklerotischen Anämie”. Verhandl Dtsch Ges Path 30: 381

    Google Scholar 

  83. di Guglielmo G (1917) Un caso di eritroleucemia. Folia Med 13: 386

    Google Scholar 

  84. Gunz FW (1977) Myelofibrosis. In: Williams WJ, Beutler E, Erslev AJ, Rundles RW (eds) Hematology, 2nd edn. McGraw-Hill, New York, p 797

    Google Scholar 

  85. Haas OA, Gadner H, Nacheva E, Fischer P, Schmidmeier W (1982) The Significance of Chromosomal Findings in Myeloid Leukemia of Childhood. Blut: 45: 207

    Google Scholar 

  86. Hauswaldt Ch, Raju S, Bianchi L, Hunstein W (1967) Kasuistischer Beitrag zum Krankheitsbild der akuten Eosinophilen-Leukämie. Acta haemat 37: 143

    PubMed  CAS  Google Scholar 

  87. Heinivara O, Kaipainen WJ (1962) Pseudo-Pelger leukocytic anomaly in haematologie disorders. Acta Pathol Microbiol Scand 54: 269

    Google Scholar 

  88. Heller A (1973) Formvariabilitäten von sog. Auerstäbchen bei akuten Leukosen. Med Welt 24: 733

    PubMed  CAS  Google Scholar 

  89. Hellriegel KP (1976) Zytogenetische Befunde bei chronischer myeloischer Leukämie. In: Stacher A, Höcker P (eds) Erkrankungen der Myelopoese. Leukämien, myeloproliferatives Syndrom, Polyzythämie. Urban und Schwarzenberg, München, S 82–86

    Google Scholar 

  90. Hennekeuser HH, Fischer R, Talke H, Mainzer K (1956) Pseu-do-Pelger-Zellen vom homozygoten Typ bei unreifzelliger myeloischer Leukämie. Dtsch Med Wschr 94: 2284

    Google Scholar 

  91. Herrmann R, Ho AD, Dörken B, Möller P (1981) Zwei Fälle von TdT-positiver akuter myeloischer Leukämie. Onkologie 4: 276

    Google Scholar 

  92. Heuck G (1879) Zwei Fälle von Leukämie mit eigenthümlichem Blutresp. Knochenmarksbefund. Virchows Arch path Anat 78:475

    Google Scholar 

  93. von Heyden HW, Waller HD, Pape GR, Benöhr HC, Braun HJ, Wilms K, Rieber EP, Riethmüller G (1976) Haarzell-Leukämie.I. Klinik, Zytochemie, Phagozytosefähigkeit von Haarzellen, Etablierung permanent wachsender Zellinien. Dtsch Med Wschr 101:3

    PubMed  CAS  Google Scholar 

  94. von Heyden HW (1979) Haarzell-Leukämie. II. Diagnostik und Verläufe bei 12 Patienten. Dtsch Med Wschr 104: 467

    Google Scholar 

  95. Heyssel R, Brill AM, Woodbury LA, Nishimura ET, Ghose T, Hoshino T, Yamasaki M (1960) Leukemia in Hiroshima atomic bomb survivors. Blood 15: 313

    PubMed  CAS  Google Scholar 

  96. Hittmaier A, Rittmann R (1926) Über azuro-eosinophile Leukozyteneinlagerungen. Ein Beitrag zur Kenntnis der akuten Myelosen mit Zelleinschlüssen. Haematologica 7: 149

    Google Scholar 

  97. Ho AD, Hunstein W, Uhl N, Storch HH (1981) Bedeutung der terminalen Desoxynucleotidyltransferase bei akuten Leukämien und bei malignen Lymphomen. Dtsch Med Wschr 106: 643

    PubMed  CAS  Google Scholar 

  98. Homy HP, Parwaresch MR, Lennert K (1983) Basophilenleuk- ämie und generalisierte Mastozytose. Verhandl Dtsch Ges Path 67:192

    Google Scholar 

  99. Hubler WR, Netherton EW (1947) Cutaneous manifestations of monocytic leukemia. Arch Dermatol Syphilis 56: 70

    CAS  Google Scholar 

  100. Jaffe ES, Shevach EM, Frank MM, Green J (1974) Leukemic reticuloendotheliosis: presence of a receptor for cytophilic antibody. Amer J Med 57:108

    PubMed  CAS  Google Scholar 

  101. Jaffé RH (1935) Histologic studies on the spleen in cases of leukemia. Arch Path 19: 647

    Google Scholar 

  102. Kass L (1977) Nonspecific esterase activity in „hairy cells”. Acta haemat 58:103

    PubMed  CAS  Google Scholar 

  103. Katayama I, Li CY, Yam LT (1972) Ultrastructural characteristics of the „hairy cells” of leukemic reticuloendotheliosis. Amer J Path 67:361

    PubMed  CAS  Google Scholar 

  104. Katayama J, Finkel H (1974) Leukemic reticuloendotheliosis. A clinicopathologic study with review of the literature. Amer J Med 57:115

    PubMed  CAS  Google Scholar 

  105. Kautz D, Schaefer HE, Fischer R (1980) Das Verhalten der Osteoklasten bei Osteomyelofibrose unter Berücksichtigung histochemischer und morphometrischer Befunde. Verhandl Dtsch Ges Path 64: 569

    Google Scholar 

  106. Kautz D (1981) Histomorphometrische Untersuchungen der Beckenkammspongiosa bei Osteomyelofibrose unter Berücksichtigung der sauren Osteoklastenphosphatase

    Google Scholar 

  107. Kirchen ME, Marshall GJ (1976) Marrow storage cells: Un ultrastructural study. J Reticuloendothelial Soc 19: 109

    CAS  Google Scholar 

  108. Kung PC, Long JC, McCafrey RP, Ratliff RL, Harrison TA, Baltimore D (1978) Terminal deoxynucleotidyl transferase in the diagnosis of leukemia and malignant lymphoma. Amer J Med 64:788

    PubMed  CAS  Google Scholar 

  109. Lagerlöf B (1972) Cytophotometric study of megakaryocyte ploidy in polycythemia vera and chronic granulocytic leukemia. Acta cytol 16: 240

    PubMed  Google Scholar 

  110. Leder LD (1970) Akute myelo-monocytäre Leukämie mit atypischen Naphthol-AS-D-Chloroacetat-Esterase-positiven Eosinophilen. Acta haemat 44: 52

    PubMed  CAS  Google Scholar 

  111. Lee KS, Tobin MS, Chen KTK, Ahmed F, Gomez-Leon G (1982) Acquired Gaucher’s cells in Hodgkin’s disease. Amer J Med 73:290

    PubMed  CAS  Google Scholar 

  112. Lee RE, Ellis LD (1971) The storage cells of chronic myelogenous leukemia. Lab Invest 24: 261

    PubMed  CAS  Google Scholar 

  113. Lennert K (1962) Zur Pathologischen Anatomie der Urticaria pigmentosa und Mastzellreticulose. Klin Wschr 40: 61

    PubMed  CAS  Google Scholar 

  114. Lennert K, Parwaresch MR (1979) Mast cells and mast cell neoplasia: a review. Histopathology 3: 349

    PubMed  CAS  Google Scholar 

  115. Lindner HJ, Linker H, Schaefer HE (1981) Zytochemisch und ultrastrukturell nachweisbare ringförmige Einschlüsse bei akuter myeloischer Leukämie. Blut 43: 14

    Google Scholar 

  116. Löffler H, Lück R, Syed Ali S (1975) Eosinophilenleukämie mit Chloracetat-Esterase-positiven Granula bei einem Kinde. Dtsch Med Wschr 100: 2092

    PubMed  Google Scholar 

  117. Löffler H (1978) Die akuten (unreifzelligen) Leukämien. In: Queißer W (ed) Das Knochenmark, Morphologie - Funktion - Diagnostik. Thieme, Stuttgart, S 273–294

    Google Scholar 

  118. Löffler W (1936) Endocarditis parietalis fibroplastica mit Bluteosinophilie. Schweiz Med Wschr 66: 817

    Google Scholar 

  119. Löffler W, Essellier AF, Macado ME (1948) Zur Pathogenese und Ätiologie der flüchtigen Lungeninfiltrate mit Bluteosinophilie (Löfflersches Syndrom). Helvetica Med Acta 15: 223

    Google Scholar 

  120. Lorbacher P, Yam L, Quaynor E (1968) Cytochemischer Nachweis von ß-Glucuronidase in normalen und leukämischen Blut-lymphocyten. Klin Wschr 46:1046

    PubMed  CAS  Google Scholar 

  121. McKee C, Collins RD (1974) Intracerebral leukocyte thrombi and aggregates as a cause of morbidity and mortality in leukemia. Medicine 53:463

    PubMed  Google Scholar 

  122. Maldonado JE, Pintado T, Pierre RV (1974) Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. I. The platelets: Ultrastructure and peroxidase reaction. Blood 43: 797

    PubMed  CAS  Google Scholar 

  123. Maldonado JE (1974) Dysplastic platelets and circulating megakaryocytes in chronic myeloproliferative diseases. II. Ultrastructure of circulating megakaryocytes. Blood 43: 811

    PubMed  CAS  Google Scholar 

  124. Mason JE, de Vita VT, Canello GP (1974) Thrombocytosis in chronic granulocytic leukemia: Incidence and clinical significance. Blood 44: 483

    PubMed  Google Scholar 

  125. Mertelsmann R, Thaler HT, To L, Gee TS, McKenzie S, Schauer P, Friedman A, Arlin Z, Cirrincione C, Clarkson B (1980) Morphologic classification, response to therapy, and survival in 263 adult patients with acute nonlymphoblastic leukemia. Blood 56:773

    PubMed  CAS  Google Scholar 

  126. Minot GR, Buckman TE (1925) The blood platelets in the leukemias. Amer J Med Sei 169: 477

    Google Scholar 

  127. Möbius W (1970) Liquorzelldiagnostik mit der Sedimentkammermethode. Med Welt (NF) 21: 846

    Google Scholar 

  128. Moloney WC (1955) Leukemia in survivors of atomic bombing. New Engl J Med 253:88

    PubMed  CAS  Google Scholar 

  129. Moore EW, Thomas LB, Shaw RK, Freireich EJ (1960) The central nervous system in acute leukemia. Arch intern Med 105: 451

    PubMed  CAS  Google Scholar 

  130. Morley AA, Baikie AG, Galton DAG (1967) Cyclic leucocytosis as evidence for retention of normal haemostatic control in chronic granulocytic leukemia. Lancet II: 1320

    Google Scholar 

  131. Naegeli O (1900) Ueber rothes Knochenmark und Myeloblasten. Dtsch Med Wschr 26: 287

    Google Scholar 

  132. Naegeli O (1931) Blutkrankheiten und Blutdiagnostik. Springer, Berlin

    Google Scholar 

  133. Negri-Gualdi C (1967) Emile Weil’s chronic myeloid leukemia with polynucleated neutrophils. Minerva Med 58: 3850

    PubMed  CAS  Google Scholar 

  134. Neumann E (1870) Ein Fall von Leukämie mit Erkrankung des Knochenmarkes. Arch Heilk 11:1

    Google Scholar 

  135. Neumann E (1878) Über myelogene Leukämie. Berlin klin Wschr 15: 69

    Google Scholar 

  136. Niederle N, Hellriegel KP, Schaefer HE (1976) Zur Problematik „gaucherartiger Zellen” bei der chronischen myeloischen Leukämie. In: Stacher A, Höcker P (eds) Erkrankungen der Myelopoese. Urban und Schwarzenberg, München, S 313–315

    Google Scholar 

  137. Niederle N, Hellriegel KP (1978) Primärer Blastenschub bei chronischer myeloischer Leukämie. Verhandl Dtsch Ges innere Med 84:173

    Google Scholar 

  138. Nies BA, Thomas LB, Freireich E (1965) Meningeal leukemia. Cancer 18: 546

    PubMed  CAS  Google Scholar 

  139. Ninni M, Belloni F (1953) Sulla transformazione della leucemia mieloide cronica in leucemia basofila subacuta. Haematologica 37: 1455

    Google Scholar 

  140. Nowell PC, Hungerford DA (1960) A minute chromosome in human chronic granulocytic leukemia. Science 132:1497

    Google Scholar 

  141. O’Riordan ML, Robinson JA, Buckton KE, Evans HJ (1971) Distinguishing between the chromosomes involved in Down’s syndrome (trisomy 21) and chronic myeloid leukemia (Ph1) by fluorescence. Nature 230:167

    PubMed  Google Scholar 

  142. Osler W (1903) Chronic cyanosis, with polycythaemia and enlarged spleen: A new clinical entity. Amer J Med Sei 126:187

    Google Scholar 

  143. den Ottolander GJ, te Velde J, Brederoo P, Geraedts JPM, Slee PHT, Wellemze SR, Zwaan FE, Haak HL, Muller HP, Beiger R (1979) Megakaryoblastic leukemia (acute myelofibrosis): a report of three cases. Brit J Haematol 42: 9

    Google Scholar 

  144. Paietta E, Schwarzmeier JD (1982) Terminal Deoxynucleotidyl Transferase (TDT): Its Significance in the Classification of Hematological Diseases. Blut 45:205

    Google Scholar 

  145. Palakovongs P, Teichberg S, Vinciguerra V, Degnan TJ, Sinlaratana P (1977) Ultrastructural cytochemical analysis of blastic transformation of chronic myelocytic leukemia. Blood 49:535

    Google Scholar 

  146. Plenderleith IH (1970) Hairy cell leukemia. Canad Med Ass J 102:1056

    PubMed  CAS  Google Scholar 

  147. Rawson R, Parker F, Jackson H (1941) Industrial solvents as possible etiologic agents in myeloid metaplasia. Science 93:541

    PubMed  CAS  Google Scholar 

  148. Reschad H, Schilling-Torgau V (1913) Über eine Leukämie durch echte Übergangsformen (Splenozytenleukämie) und ihre Bedeutung für die Selbständigkeit dieser Zellen. Münch Med Wschr 60: 1981

    Google Scholar 

  149. Rieber EP, v Heyden HW, Linke RP, Saal JG, Riethmüller G, Waller HD (1976) Haarzell-Leukämie. Charakterisierung der leukämischen Zelle: Oberflächen-Immunglobuline, Fc-Rezeptoren und Stimulation durch Mitogene. Klin Wschr 54:1011

    PubMed  CAS  Google Scholar 

  150. Rodermund O-E, Hauser W, Burkhardt R, Grips KH, Stein G (1978) Veränderungen am Knochenmark bei Mastozytose. Dermatol Monatsschr 164: 493

    PubMed  CAS  Google Scholar 

  151. Rosenthal S, Canellos GP, DeVita VT, Gralnick HR (1977) Characteristics of blast crisis in chronic granulocytic leukemia. Blood 49:705

    PubMed  CAS  Google Scholar 

  152. Ross R, Vogel R (1980) The platelet derived growth factor. Cell 14: 203

    Google Scholar 

  153. Rowley JE (1973) The Ph1 chromosome: evidence for a specific chromosomal translocation. J clin Invest 52: 71a

    Google Scholar 

  154. Rowley JD (1976) The role of cytogenetics in hematology. Blood 48: 1

    PubMed  CAS  Google Scholar 

  155. Rubin H (1966) Chronic neutrophilic leukemia. Ann intern Med 65:93

    PubMed  CAS  Google Scholar 

  156. Rundles WR (1973) Chronic granulocytic leukemia. In: Williams WJ, Beutler E, Erslev AJ, Rundles WR (eds) Hematology. McGraw-Hill, New York, pp 680–695

    Google Scholar 

  157. Rundles WR (1977) Chronic granulocytic leukemia. In: Williams WJ, Beutler E, Erslev AJ, Rundles WR (eds) Hematology, 2nd edn. McGraw-Hill, New York, pp 777–796

    Google Scholar 

  158. Ruzicka F, Pawlowsky J, Erber A, Nowotny H (1976) Drei Fälle von Eosinophilenleukämie mit atypischer Granulation in Eosinophilen und Neutrophilen. Blut 32: 337

    PubMed  CAS  Google Scholar 

  159. Sagher F, Even-Paz Z (1967) Mastocytosis and mast cell. Karger, Basel

    Google Scholar 

  160. Sayk J (1960) Cytologie der Cerebrospinalflüssigkeit. Fischer, Jena

    Google Scholar 

  161. Schaefer HE, Hellriegel KP, Hennekeuser HH, Hübner G, Zach J, Fischer R, Gross R (1973) Eosinophilenleukämie, eine unreifzellige Myelose mit Chloracetatesterase-positiver Eosinophilie. Blut 26:7

    PubMed  CAS  Google Scholar 

  162. Schaefer HE, Hellriegel KP, Fischer R (1977) Der cytochemische Nachweis der Eosinophilen-Peroxidase unter besonderer Berücksichtigung des isolierten Peroxydasedefektes in Eosinophilen. Acta histochem Suppl XVIII 195

    Google Scholar 

  163. Schaefer HE, Schmalzl F, Fischer R (1978) Stammen eosinophile und neutrophile Granulozyten von einer gemeinsamen promyelozytären Vorstufe ab? Untersuchungen an der normalen, peroxydasedefekten und leukämischen Granulopoiese. Verhandl Dtsch Ges Path 62: 343

    CAS  Google Scholar 

  164. Schaefer HE, Weller P, Lansch D (1983) Erworbene und ererbte Defektformen der granulozytären Peroxidase (POX). Acta histochem Suppl XXVIII 219

    Google Scholar 

  165. Schaefer HE (1983) Zur Zytologie und Histologie des normalen menschlichen Knochenmarkes. Verhandl Dtsch Ges Path 67:80

    CAS  Google Scholar 

  166. Schmahl M (1983) Pseudogaucherzellen und Megakaryozyten bei der chronischen myeloischen Leukämie. - Häufigkeit, wechselseitige Beziehung und prognostische Bedeutung - Inauguraldissertation, Köln

    Google Scholar 

  167. Schmalzl F, Braunsteiner H (1968) Zur Cytochemie der Monocytenleukämie. Klin Wschr 46: 1185

    Google Scholar 

  168. Schmalzl F, Huhn D, Asamer H, Rindler R, Braunsteiner H (1973) Cytochemistry and ultrastructure of pathologic granulation in myelogenous leukemia. Blut 27:243

    PubMed  CAS  Google Scholar 

  169. Sézary A (1952) Les réticuloses cutanées. Bull Soc franc Derm Ann Derm Syph 79:378

    Google Scholar 

  170. Shaw MT (1974) „Pure” monocytic leukemia: A revised concept. Proc Amer Soc Clin Oncol 15:162

    Google Scholar 

  171. Silverstein MN, Gomes MR, ReMine WH, Elveback LR (1967) Agnogenic myeloid metaplasia. Arch intern Med 120:546

    PubMed  CAS  Google Scholar 

  172. van Slyck EJ, Weiss L, Dully M (1970) Chromosomal evidence for the secondary role of fibroblastic proliferation in acute myelofibrosis. Blood 36: 729

    PubMed  Google Scholar 

  173. Spiers ASD (1974) Chronic granulocytic leukaemia and chronic lymphocytic leukaemia. Brit Med J: 4: 460

    PubMed  CAS  Google Scholar 

  174. Srodes CH, Hyde EH, Boggs DR (1973) Autonomous erythroid megaloblastosis occurring during blastic transformation of chronic myelocytic leukemia. J clin Invest 52:512

    PubMed  CAS  Google Scholar 

  175. Stacher A, Höcker P (eds) Erkrankungen der Myelopoese. Leukämien, myeloproliferatives Syndrom, Polycythämie. Urban und Schwarzenberg, München

    Google Scholar 

  176. Stass SA, Veach S, Pasquale SM, Schumacher HR, Keneklis TP, Bollum FJ (1978) Terminal-deoxynucleotidyl-transferase positive acute lymphoblastic leukaemia with Auer rods. Lancet I: 1042

    Google Scholar 

  177. Terheggen HG, Haug H, Hellriegel KP, Schaefer HE (1975) Der sogenannte infantile Typ der chronischen myeloischen Leukämie. Zschr Kinderheilk 119:123

    CAS  Google Scholar 

  178. Thiele J, Vykoupil KF, Georgii A (1979) Chronic myelomonocytic leukemia: Light and electron microscopy of the bone marrow. Blut 39:177

    PubMed  CAS  Google Scholar 

  179. Thiele J, Holgado S, Choritz A, Georgii A (1982) Abnormalities of megakaryocytes in myelitis and chronic myeloproliferative diseases. Virchows Arch (Cell Pathol) 41:67

    CAS  Google Scholar 

  180. Thomas LB (1965) Pathology of leukemia in the brain and meninges: Postmortem studies of patients with acute leukemia and of mice given inoculations of L 1210 leukemia. Cancer Res 25: 1555

    PubMed  CAS  Google Scholar 

  181. Tjio JH, Carbone PP, Whang J, Frei E (1966) The Philadelphia chromosome in chronic myelogenous leukemia. J nat Cancer Inst 36:567

    PubMed  CAS  Google Scholar 

  182. Tough IM, Court Brown WM (1965) Chromosome aberrations and exposure to ambient benzene. Lancet I: 684

    Google Scholar 

  183. Tough IM (1965) Cytogenetic studies in cases of myeloid leukemia with a previous history of radiation. In: Hayhoe FGJ (ed) Current Research in Leukemia. Cambridge University Press, London, p 47

    Google Scholar 

  184. Tulliez M, Vemant JP, Breton-Gorius J, Imbert M, Sultan C (1979) Pseudo-Chediak-Higashi anomaly in a case of acute myeloid leukemia: electron microscopic studies. Blood 54:863

    PubMed  CAS  Google Scholar 

  185. Undritz E (1969) Die Differentialdiagnose der malignen Hämoblastosen. In: Stacher A (ed) Chemo- und Immunotherapie der Leukosen und malignen Lymphome. Bohmann, Wien, S 101

    Google Scholar 

  186. Vanivich S, Marks SM, Rosenthal DS, Moloney WC, Schlossman SF (1979) Cell-surface characteristics of hairy cell leukemia in seven patients. Cancer 43: 2348

    Google Scholar 

  187. Vaquez MH (1892) Sur une forme speciale de cyanose s’accom-pagnant d’hyperglobulie excessive et persistante. Compt rend Soc Biol 44: 384

    Google Scholar 

  188. Vaughn JM (1936) Leuco-erythroblastic anaemia. J Pathol 42: 541

    CAS  Google Scholar 

  189. te Velde J, Vismans FJEF, Leenheers-Binnendijk L, Vos CJ, Sneenk D, Bijvoet OLM (1978) The eosinophilic fibrohistiocytic lesion of the bone marrow. A mastocellular lesion in bone disease. Virchows Arch A 377: 277

    Google Scholar 

  190. Vigliani EC, Saita G (1964) Benzene and leukemia. New Engl J Med 271:872

    PubMed  CAS  Google Scholar 

  191. Virchow R (1845) Weißes Blut. Froriep’s Notizen 36:151

    Google Scholar 

  192. Wasastjema C, Vuorinen E, Lehtinen M, Ikkala E, Huhtala E (1975) The cytochemical ß-glucuronidase reaction in the differential diagnosis of acute leukaemias. Acta Haematologica 53: 277

    Google Scholar 

  193. Werner W, Krause AP (1965) Die Gewebsmastzellen im menschlichen Knochenmark. Frankf Zschr Path 74: 651

    PubMed  CAS  Google Scholar 

  194. Wheldon TE, Kirk J, Finlay HM (1974) Cyclic granulopoiesis in chronic granulocytic leukemia: A simulation study. Blood 43:379

    PubMed  CAS  Google Scholar 

  195. Wiener L (1965) A family with a high incidence of leukemia and unique Ph1 chromosome findings. Blood 26: 871

    Google Scholar 

  196. Woessner S, Lafuente R, Pardo P, Rosseil R, Rozman C, Sans-Sabrafen J (1977) Systemic mastocytosis: a case report. Cytological, cytochemical and ultrastructural considerations. Acta haemat 58: 321

    PubMed  CAS  Google Scholar 

  197. Wolk RN, Masse SR, Conklin R, Freireich EJ (1974) Incidence of central nervous system leukemia in adults. Cancer 33: 863

    PubMed  CAS  Google Scholar 

  198. Zaino EC, Rossi MB, Pham TD, Azar HA (1971) Gaucher’s cells in thalassemia. Blood 38: 457

    PubMed  CAS  Google Scholar 

  199. Zittoun R, Bemadou A, Bilski-Pasquier G, Bousser J (1972) Les leucémies myélo-monocytaires subaigues. Etudes de 27 cas et revue de la littérature. Sem Höpit (Paris) 48:1943

    CAS  Google Scholar 

  200. Zittoun R (1976) Subacute and chronic myelomonocytic leukaemia: A distinct haematological entity. Brit J Haematol 32: 1

    CAS  Google Scholar 

Literatur

  1. Barka T (1960) A simple azo-dye method for histochemical demonstration of acid phosphatase. Nature 187: 248–249

    PubMed  Google Scholar 

  2. Bartl R Weichert HC, Schmitt G, Firusian N, Wetter O (1978) Rationelle Beckenkamm-Biopsie. Langsteilung der Proben zur Anwendung von mehreren Präparationsverfahren ohne Materialverlust. Klin Wschr. 56: 545–550

    PubMed  CAS  Google Scholar 

  3. Bauer-Sić P (1966) Signifikante Veranderung des alkalischen Leukozytenphosphatase-Index während des menstruellen Zyklus. Acta endocrin 52: 130–148

    Google Scholar 

  4. Beckstead JH, Halverson PS, Ries CA, Bainton DF (1981) Enzyme histochemistry and immunohistochemistry on biopsy specimens of patholic human bone marrow. Blood 57: 1088–1098

    PubMed  CAS  Google Scholar 

  5. Beisel WR, Benjamin N, Austen KF (1953) Absence of leukocyte alkaline phosphatase activity in hypophosphatasia. Blood 14: 975–977

    Google Scholar 

  6. Beisel WR (1967) Neutrophile alkaline phosphatase changes in tularemia, sandfly fever, Q-fever and oninfectious fevers. Blood 29: 257–268

    PubMed  CAS  Google Scholar 

  7. Beutler E, Ohno S, Goldenburg EW, Yettra M (1964) Chromosome-21 and paroxysmal natumal hemoglobinuria. Blood 24: 160–163

    PubMed  CAS  Google Scholar 

  8. Burkhardt R (1956) Die Myelotomie, eine neue Methode zur kombinierten cytologisch-histologischen Knochenmarksbiopsie. Blut 2: 267

    PubMed  CAS  Google Scholar 

  9. Burkhardt R (1966) Ein neues Verfahren zur histologischen Präparation von Biopsien aus Knochenmark und Knochen. Blut 14: 30

    PubMed  CAS  Google Scholar 

  10. Curran RC, Gregory J (1980) Effects of fixation and processing on immunohistochemical demonstration of immunoglobulin in paraffin sections of tonsil and bone marrow. J clin Pathol 338: 1047–1057

    Google Scholar 

  11. Davis BJ, Omstein L (1959) High resolution enzyme localization with a new diazo reagent, „hexazonium pararosaniline”. J Histochem Cytochem 7:297

    Google Scholar 

  12. Dempsey SI, Crockard AD, Brigges JM (1980) An estimation of β-Glucuronidase and N-Acetyl-β-D-Glucosaminidase activity in normal and chronic lymphocytic leukaemia lymphocytes

    Google Scholar 

  13. Goldenberg AF, Barka T (1962) Acid phosphatase activity in human blood cells. Nature 195:297

    Google Scholar 

  14. Gomori G (1953) Chloracylesters as histochemical substrates. J Histochem Cytochem 1: 469–470

    PubMed  CAS  Google Scholar 

  15. Hautzer NW, Wittkuhn JF, McCaughey WTE (1980) Trypsin digestion in immunoperoxidase staining. J Histochem Cytochem 28:52–53

    PubMed  CAS  Google Scholar 

  16. Hayashi M, Nakajima Y, Fishman WH (1964) The cytologic demonstration of β -glucuronidase employing naphthol-AS-BI glucuronide and hexazonium pararosanilin; a preliminary report. J Histochem Cytochem 12: 293–297

    PubMed  CAS  Google Scholar 

  17. Horwitz DA, Allison AC, Ward P, Kight N (1977) Identification of human mononuclear leucocyte populations by esterase staining. Clin exper Immunol 30: 289–298

    CAS  Google Scholar 

  18. Hsu SM, Raine L (1982) Versatility of biotin-labeled lectins and avidin-biotin-peroxidase complex for localization of carbohydrate in tissue sections. J Histochem Cytochem 30:157–161

    PubMed  CAS  Google Scholar 

  19. Kaplow LS (1955) A histochemical procedure for localizing and evaluating leukocyte alkaline phosphatase activity in smears of blood and marrow. Blood 10: 1023–1029

    PubMed  CAS  Google Scholar 

  20. Kaplow LS (1963) Cytochemistry of leukocyte alkaline phosphatase. Use of complex naphthol-AS-phosphate in azo dye-coupling technics. Am J clin Pathol 39: 439–449

    CAS  Google Scholar 

  21. Laskowski M (1971) Venom exonuclease. In: Boyer PD (ed) The enzymes, Vol IV, 3. ed. Academic Press, New York, pp 313–328

    Google Scholar 

  22. Leder LD (1964) Über die selektive fermentcytochemische Darstellung von neutrophilen myeloischen Zellen und Gewebsmastzellen im Paraffinschnitt. Klin Wschr 42: 553–555

    PubMed  CAS  Google Scholar 

  23. Lewis SM, Dacie JO (1965) Neutrophil (leucocyte) alkaline phosphatase in paroxysmal nocturnal haemoglobinuria. Brit J Haemat 11: 549–556

    PubMed  CAS  Google Scholar 

  24. Lorbacher P (1969) Der zytochemische β -Glucuronidasenachweis; ein Beitrag zur Differenzierung lymphatischer Leukosen. In: Stacher A (ed) Chemo- und Immunotherapie der Leukosen und malignen Lymphome. Bohmann, Wien, p 160

    Google Scholar 

  25. Moloney WC, Me Pherson L, Fliegelman L (1960) Esterase activity in leucocytes demonstrated by the use of Naphthol AS-D chloroazetate substrate. J Histochem Cytochem 8: 200–207

    PubMed  CAS  Google Scholar 

  26. Müller D (1967) Zur Frage der endokrinen Beeinflussung der alkalischen Leukozytenphosphatase. Blut 14: 273–276

    PubMed  Google Scholar 

  27. Mueller J, del Brun R, Buerki H, Keller HU, Hess MW, Cottier H (1975) Nonspecific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes. Europ J Immunol 5: 270–274

    CAS  Google Scholar 

  28. Peris M (1867) Nachweis von Eisenoxyd in gewissen Pigmenten. Virchows Arch pathol Anat 39: 42–48

    Google Scholar 

  29. Pralle H, Löffler H (1979) Erythrocytosis with alkaline phosphatase in the membrane of the erythrocytes. Intern Soc Haematol Europ African Div 5th Meeting, Abstracts IV, 32

    Google Scholar 

  30. Quigley HJ, Dawson EA, Hyun BH, Custer RP (1960) The activity of alkaline phosphatase in granular leukocytes during pregnancy and the puerperium: A preliminary report. Amer J clin Path 33:109–114

    CAS  Google Scholar 

  31. Schaefer HE, Hellriegel KP, Fischer R (1977) Vorkommen von tartratresistenter saurer Phosphatase in verschiedenen Zelltypen des lymphoretikulären und hämatopoetischen Zellsystems. Blut 34:393–397

    PubMed  CAS  Google Scholar 

  32. Schaefer HE (1980) Ein atypisches Verteilungsmuster der tartratresistenten sauren Phosphatase in Osteoklasten bei Ostitits deformans Paget - zur pathogenetischen und diagnostischen Bedeutung. Verhandl Dtsch Ges Path 64: 569

    Google Scholar 

  33. Schaefer HE (1983) Zur Zytologie und Histologie des normalen menschlichen Knochenmarkes. Verhandl Dtsch Ges Path 67: 80–100

    CAS  Google Scholar 

  34. Schaefer HE (1983) Neuere histochemische Aspekte zur Differenzierung und Funktion normaler und pathologischer Blutzellen. Eine Einführung zur Thematik. Acta histochem, Suppl XXVIII 129–133

    Google Scholar 

  35. Schaefer HE, Assmann G (1983) Das Verhalten lymphozytärer Lysosomen bei der Cholesterinester-Speicherkrankheit (CESK). Acta histochem, Suppl XXVI 135–148

    Google Scholar 

  36. Schaefer HE, Weller P, Lansch D (1983) Erworbene und ererbte Defektformen der granulozytären Peroxidase (POX). Acta histochem, Suppl XXVIII 219–234

    Google Scholar 

  37. Seifert G, Denk H, Klein JH, Stein H, Otto HF (1984) Die Anwendung der Immunzytochemie in der praktischen Diagnostik des Pathologen. Pathologe 5:187–199

    PubMed  CAS  Google Scholar 

  38. Shugar D, Sierakowska H (1967) Mammalian nucleolytic enzymes and their localization. Progr Nucleic Acid Res 7: 396–429

    Google Scholar 

  39. Sierakowska H, Shugar D (1963) Cytochemical localization of phosphodiesterase by the azo dye simultaneous coupling method. Biochem Biophys Res Comm 11: 70–75

    PubMed  CAS  Google Scholar 

  40. Trubowitz S, Moschides E, Feldman D (1961) Alkaline phosphatase activity of the polymorphonuclear leukocyte in rapidly induced leukopenia and leukocytosis. J lab clin Med 57: 747–754

    PubMed  CAS  Google Scholar 

  41. Undritz E (1965) Zur Aktivität der alkalischen Phosphatase bei der chronisch myeloischen Leukämie. Schweiz Med Wschr 95: 1515–1519

    PubMed  CAS  Google Scholar 

  42. Valentine WN, Follette JH, Hardin EB, Beck WS Lawrence JS (1954) Studies on leucocyte alkaline phosphatase activity: relation to „stress” and pituitary-adrenal activity. J lab clin Med 44: 219–228

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. H. E. Schaefer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Kliniken der Landeshauptstadt, Institut für Pathologie, Ludwig Erhard-Straße 100, 6200, Wiesbaden, Deutschland

    Wolfgang Remmele

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schaefer, H.E. (1984). Leukopoese und myeloproliferative Erkrankungen. In: Remmele, W. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-97874-6_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-97874-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-97875-3

  • Online ISBN: 978-3-642-97874-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation