Zusammenfassung
Beweglichkeit ist eine Eigenschaft, die bei heterotrophen Organismen aller Entwicklungsstufen gefunden wird und diese in die Lage versetzt, ihre Energieversorgung optimal zu gestalten, negative Einflüsse zu meiden und eine für ihre Vermehrung günstige Umgebung zu erreichen und dauerhaft zu besiedeln. Obwohl Bakterien verschiedene Möglichkeiten der Beweglichkeit haben, wird im folgenden nur noch von der mit Abstand effektivsten (und am besten untersuchten) Form bakterieller Motiltiät die Rede sein: der flagellenvermittelten Beweglichkeit. Die von Geißeln (Flagellen), hochspezialisierten Fortbewegungsorganellen, vermittelte Motilität ist bei sehr ursprünglichen Arten (z. B. methanogenen oder halophilen Organismen) ebenso zu finden wie bei ubiquitären Umweltbesiedlern und den hochentwickelten speziell angepaßten Krankheitserregern des Menschen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Alm RA, Guerry P, Trust TJ (1993) The Campylobacter sigma 54 flaB flagellin promoter is subject to environmental regulation. J Bacteriol 175: 4448–4455
Alm RA, Guerry P, Trust TJ (1993) Significance of duplicated flagellin genes in Campylobacter. J Mol Biol 230: 359–363
Blaser MJ (1994) Helicobacter pylori: microbiology of a „slow“ bacterial infection. Trends Microbiol 1: 255–260
Carsiotis M, Weinstein DL, Karch H, Holder IA, O’Brien AD (1984) Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice. Infect Immun 46: 814–818
Driks A, Bryan R, Shapiro L, DeRosier DJ (1989) The organization of the Caulobacter crescentus flagellar filament J Mol Biol 206: 627–636
Eaton KA, Morgan DR, Krakowka S (1989) Campylobacter pylori virulence factors in gnotobiotic piglets. Infect Immun 57: 1119–1125
Eaton KA, Morgan DR, Krakowka S (1992) Motility as a factor in the colonisation of gnotobiotic piglets by Helicobacter pylori. J Med Microbiol 37: 123–127
Ferrero RL, Cussac V, Courcoux P, Labigne A (1992) Construction of isogenic urease negativemutants of Helicobacter pylori by allelic exchange. J Bacteriol 174: 4212–4217
Fox JG, Correa P, Taylor NS, Lee A, Otto G, Murphy JC, Rose R (1990) Helicobacter mustelae-associated gastritis in ferrets. An animal model of Helicobacter pylori gastritis in humans. Gastroenterology 99. 352–361
Geis G, Leying H, Suerbaum S, Mai U, OpferkuchW (1989) Ultrastructure and chemical analysis of Campylobacter pylori flagella. J Clin Microbiol 27: 436–441
Geis G, Suerbaum S, Forsthoff B, Leying H, Opferkuch W (1993) Ultrastructure and biochemical studies of Helicobacter pylori flagellar sheath. J Med Microbiol 38: 371–377
Gerl L, Deutzmann R, Sumper M 81989) Halobacterial flagellins are encoded by a multigene familiy. Identification of all five gene products. FEBS Lett 244: 137–140
Guentzel MN, Berry LJ (1975) Motility as a virulence factor for Vibrio cholerae. Infect Immun 11: 890–897
Guerry P, Alm RA, Power ME, Logan SM, Trust TJ (1991) Role of two flagellin genes in Campylobacter motility. J Bacteriol 173: 4757–4764
Hazen SL, Lee A, Brady L, Hennessy W (1986) Campylobacter pyloridis and gastritis: association with intercellular spaces and adaption to an environment of mucus as important factors in colonization of the gastric epithelium. J Infect Dis 153: 658–663
Jones CJ, Aizawa S-I (1991) The bacterial flagellum and flagellar motor: structure, assembly and function. Adv Microb Physiol 32: 109–172
Josenhans C, Labigne A, Suerbaum S (1994) Comparative functional studies on the motility of Helicobacter pylori and Helicobacter mustelae flagellin mutants: Both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species. J Bacteriol (submitted)
Kostrzynska M, Betts JD, Austin JW, TrustTJ (1991) Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella. J Bacteriol 173: 937–946
Leying H, Suerbaum S, Geis G, Haas R (1992) Cloning and genetic characterization of a Helicobacter pylori flagellin gene. Mol Microbiol 6: 2863–2874
Majewski SI, Goodwin CS (1988) Restriction endonuclease analysis of the genome of Campylobacter pylori with a rapid extraction method: evidence fo considerable genomic variation. J Infect Dis 157: 465 —471
Morooka T, Umeda A, Amako K (1985) Motility as an intestinal colonization factor for Campylobacter jejuni. J Gen Microbiol 131: 1973–1980
Nuijten PJ, van Asten FJ, GaastraW, van der Zeijst BA (1990) Structural and functional analysis of two Campylobacter jejuni flagellin genes. J Biol Chem 265: 17798–17804
O’Rourke J, Lee A, Fox JG (1992) An ultrastructural study of Helicobacter mustelae and evidence of a specific association with gastric mucosa. J Med Microbiol 36: 420–427
Owen RI, Fraser J, Costas M, Morgan D, Morgan DR (1990) Signature patterns of DNA restriction fragments of Helicobacter pylori before and after treatment. J Clin Pathol 43: 646–649
Pleier E, Schmitt R (1989) Identification and sequence analysis of two related flagellin genes in Rhizobium meliloti. J Bacteriol 171: 1467–1475
Sjoblad RD, Emala CW, Doetsch RN (1983) Invited review: bacterial flagellar sheaths: structures in search of a function. Cell Motil 3: 96–103
Suerbaum S, Geis G, Josenhans C, Opferkuch W (1992) Biochemical studies of Helicobacter mustelae fatty acid composition and flagella. Infect Immun 60: 1695–1698
Suerbaum S, Josenhans C, Labigne A (1993) Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange. J Bacteriol 175: 3278–3288
Trachtenberg S, DeRosier DJ, Aizawa S, Macnab RM (1986) Pairwise perturbation of flagellin subunits. The structural basis for the differences between plain and complex bacterial flagellar filaments. J Mol Biol 190: 569–57
Wilson DR, Beveridge TJ (1993) Bacterial flagellar filaments and their component flagellins. Can J Microbiol 39: 451–472
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Suerbaum, S., Josenhans, C. (1994). Molekulargenetische Grundlagen der Motilität von Helicobacter pylori. In: Caspary, W.F., Kist, M., Zeitz, M. (eds) Ökosystem Darm VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85187-2_25
Download citation
DOI: https://doi.org/10.1007/978-3-642-85187-2_25
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-58548-0
Online ISBN: 978-3-642-85187-2
eBook Packages: Springer Book Archive