Skip to main content
SpringerLink
Log in

Morbus Crohn: Eine „slow bacterial“-Infektion? — Der,,klassische“ Weg der Ursachenforschung

  • Conference paper
Book cover Ökosystem Darm VI

  • 43 Accesses

Zusammenfassung

Verwirrend vieleUrsachen werden mit wechselnder Intensität diskutiert. Sie reichen von einer psychosomatischen Krankheit bis zu einer Infektionskrankheit (Abb. 1). Mit großer Sicherheit ausgeschieden sind psychische und Ernährungsfaktoren. Eine genetische Prädisposition ist bewiesen. Die kürzlich beschriebene Vaskulitis [43] wurde bisher nicht reproduziert. Eine primäre Störung der Immunregulation erscheint unwahrscheinlich. Viren konnten bisher nicht nachgewiesen werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Afdhal NH, Long A, Lennon J, Crowe J, O’Donoghue DP (1991) Controlled trial of antimycobacterial therapy in Crohn’s disease. Clofazimine versus placebo. Dig Dis Sci 36: 449X–453

    Google Scholar 

  2. Best WR, Becktel JM, Singleton JW, Kern FJr. (1976) Development of a Crohns’s disease activity index. National cooperative Crohn’s disease study. Gastroenterology 70: 439–444.

    CAS  Google Scholar 

  3. Burnham WR, Lennard-Jones, JE, Stanford JL, Bird RG (1978) Mycobacteria as a possible cause of inflammatory bowel disease. Lancet ii: 693–696

    Google Scholar 

  4. Cellier C, De Benhouwer H, Faucheron JL, Carbonnel F, Berger A, Barbier JP, Portaels F (1993) Mycobacterium paratuberculosis, and avium subsp. silvaticum DNA cannot be detected in Crohn’s disease tissues. Gastroenterology 104: A678

    Google Scholar 

  5. Chiodini RJ, van Kruiningen HJ, Merkal RS (1984) Ruminant paratuberculosis (Johne’s disease): the current status and future prospects. Cornell Vet 74: 218–262

    PubMed  CAS  Google Scholar 

  6. Chiodini RJ, van Kruiningen HJ, Merkal RS, Thayer WR Jr, Coutu JA (1984) Characteristics of an unclassified mycobacterium species isolated from patients with Crohn’s disease. J Clin Microbiol 20: 966 –971

    PubMed  CAS  Google Scholar 

  7. Chiodini RJ, van Kruiningen HJ, Thayer WR, Coutu JA (1986) Spheroplastic phase of mycobacteria isolated from patients with Crohn’s disease. J Clin Microbiol 24: 357–363

    PubMed  CAS  Google Scholar 

  8. Chiodini RJ, van Kruiningen HJ, Thayer WR, Merkal RS, Coutu JR (1984) Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn’s disease. Dig Dis Sci 29: 1073–1079

    Article  PubMed  CAS  Google Scholar 

  9. Colemont LJ, Pattyn SR, Michielsen PP, Pen JH, Pelckmans PA, van Maercke YM, Portaels F (1988) Acid-fast bacilli in Crohn’s disease. Lancet is 294–295

    Google Scholar 

  10. Coloe PJ, Wilks, CR, Lightfoot D, Tosolini FA (1986) Isolation of a Mycobacterium sp. resembling M. paratuberculosis from the bowel tissue of a patient with Crohn’s disease. Aust Microbiol 7: 188

    Google Scholar 

  11. Crohn BB, Ginzburg L, Oppenheimer GD (1932) Regional ileitis. A pathologic and clinical entity. JAMA 99: 1323–1329

    Google Scholar 

  12. Dalziel TK (1913) Chronic interstitial enteritis. Br Med J 2: 1068–1070

    Google Scholar 

  13. Das PK, Blaauwgeers JLG, Slob AW, Yong SL, Rambukkana A (1989) Mycobacterial antibody (Myc-Ab) response in relation to Crohn’s disease (CD). Gastroenterology 96: A 111

    Google Scholar 

  14. Elliott PR, Lennard-Jones JE, Burnham WR, White S, Stanford JL (1980) Further data on skin testing with mycobacterial antigens in inflammatory bowel disease. Lancet ii: 483–484

    Article  Google Scholar 

  15. Fidler HM, Thurrell W, Johnson N McI, Rook GAW, McFadden JJ (1994) Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn’s disease. Gut 35: 506 –510

    CAS  Google Scholar 

  16. Gitnick G, Collins J, Beaman B, Brooks D, Arthur M, ImaedaT, Palieschesky M (1989) Preliminary report on isolation of mycobacteria from patients with Crohn’s disease. Dig Dis Sci 34: 925– 932

    Article  PubMed  CAS  Google Scholar 

  17. Graham DY, Markesich DC, Yoshimura HH (1987) Mycobacteria and inflammatory bowel disease. Results of culture. Gastroenterology 92: 436–442

    Google Scholar 

  18. Green EP, Tizard MLV, Moss MT, Thompson J, Winterbourne DJ, McFadden JJ, Hermon-Taylor J (1989) Sequence of characteristics of IS900, an insertion element identified in a human Crohn’s disease isolate of Mycobacterium paratuberculosis. Nucleic Acids Res 17: 9063–9073

    Article  PubMed  CAS  Google Scholar 

  19. Haagsma J, Mulder CJJ, Eger A, Tytgat GNJ (1991) Mycobacterium paratuberculosis isolated from patients with Crohn’s disease. Preliminary Dutch results. Acta Endosc 21: 255–260

    Google Scholar 

  20. Haga Y (1986) Mycobacteria in Crohn’s disease. Jpn J Gastroenterol 23: 2325–2333

    Google Scholar 

  21. Hampson SJ, Parker MC, Saverymuttu SH, Joseph AE, McFadden J-JP, Hermon-Taylor J (1989)Quadruple antimycobacterial chemotherapy in Crohn’s disease: results at 9 months of a pilot study in 20 patients. Aliment Pharmacol Ther 3: 343–352

    Article  PubMed  CAS  Google Scholar 

  22. Järnerot G, Rolny P, Wickbom G, Alemayehu G (1989) Antimycobacterial therapy ineffective in Crohn’s disease after a year. Lancet is164–165

    Google Scholar 

  23. Kelleher D, O’Brien S, Weir DG (1982) Preliminary trial of clofazimine in chronic inflammatory bowel disease. Gut 23: A 449

    Google Scholar 

  24. Kohn A, Prantera C, Mangiarotti R, Luzi C, Andreoli A (1992) Antimycobacterial therapy and Crohn’s disease: a randomized placebo controlled trial. Gastroenterology 102: A 647

    Google Scholar 

  25. Koltun WA, Bloomer MM, Kauffman GL, Localio AR, Zarkower A (1993) Mycobacteria other than paratuberculosis may play a role in Crohn’s disease. Gastroenterology 104: A726

    Google Scholar 

  26. McClure HM, Chiodini RJ, Anderson DC, Swenson RB, Thayer WR, Coutu JA (1987) Mycobacterium paratuberculosis infection in a colony of stumptail macaques ( Macaca arctoides ). J Infect Dis 155: 1011–1019

    Google Scholar 

  27. van Patter W (1952) Pathology and pathogenesis of regional enteritis. PhD thesis, Univ Minnesota, USA

    Google Scholar 

  28. Picciotto A, Gesu GP, Schito GC, Testa R, Varagona G, Celle G (1988) Antimycobacterial chemotherapy in two cases of inflammatory bowel disease. Lancet is 536–537

    Google Scholar 

  29. Prantera C, Bothamley G, Levenstein S, Mangiarotti R, Argentieri R (1989) Crohn’s disease and mycobacteria: two cases of Crohn’s disease with high anti-mycobacterial antibody levels cured by dapsone therapy. Biomed Pharmacother 43: 295–299

    Article  PubMed  CAS  Google Scholar 

  30. Rachmilewitz D (1989) Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. Br Med J 298: 82–86

    Article  CAS  Google Scholar 

  31. Relman DA, Schmidt TM, MacDermott RP, Falkow S (1992) Identification of the uncultured bacillus of Whipple’s disease. N Engl J Med 327: 293–301

    Article  PubMed  CAS  Google Scholar 

  32. Reynolds DS (1963) The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J Cell Biol 17: 208–212

    Article  PubMed  CAS  Google Scholar 

  33. Rook GAW, Stanford JL (1992) Slow bacterial infections or autoimmunity2 Immunol Today 13: 160 –164

    PubMed  CAS  Google Scholar 

  34. Rosenberg WMC, Bell JI (1991) Mycobacterium paratuberculosis DNA cannot be detected in Crohn’s disease tissues. Gastroenterology 100: A611

    Google Scholar 

  35. Rutgeerts P, Vantrappen G, van Isveldt J, Geboes K (1988) Rifabutin therapy in patients with recurrent Crohn’s disease after ileocolonic resection. Gastroenterology 94: A 391

    Google Scholar 

  36. Sanderson JD, Moss MT, Tizard MLV, Hermon-Taylor J (1992) Mycobactrium paratuberculosis DNA in Crohn’s disease tissue. Gut 33: 890–896

    Article  PubMed  CAS  Google Scholar 

  37. Schultz MG, Rieder HL, Hersh T, Riepe S (1987) Remission of Crohn’s disease with antimycobacterial chemotherapy. Lancet ii: 1391–1392

    Google Scholar 

  38. Shaffer JL, Hughes S, Linaker BD, Baker RD, Turnberg LA (1984) Controlled trial of rifampicin and ethambutol in Crohn’s disease. Gut 25: 203–205

    Article  PubMed  CAS  Google Scholar 

  39. Spurr AR (1969) A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 26: 31–43

    Article  PubMed  CAS  Google Scholar 

  40. Swift GL, Srivastava ED, Stone R et al. (1994) Controlled trial of anti-tuberculous chemotherapy for two years in Crohn’s disease. Gut 35: 363–368

    Article  PubMed  CAS  Google Scholar 

  41. Thayer WR, Coutu JA, Chiodini RJ, van Kruiningen HJ (1988) Use of rifabutin and streptomycin in the therapy of Crohn’s disease. Gastroenterology 94: A 458

    Google Scholar 

  42. Visuvanathan S (1990) The characterisation of pleomorphic acid fast organisms isolated from patients with inflammatory bowel disease. MD thesis, Univ London

    Google Scholar 

  43. Wakefield AJ,Sawyerr AM,Dhillon AP,Pittilo RM,Rowles PM,Lewis AAM,Pounder RE(1989) Pathogenesis of Crohn’s disease: multifocal gastrointestinal infarction. Lancet ii: 1057–1062

    Google Scholar 

  44. Ward M, McManus JPA (1975) Dapsone in Crohn’s disease. Lancet is 1236–1237

    Google Scholar 

  45. Warren JB, Rees HC, Cox TM (1986) Remission of Crohn’s disease with tuberculosis chemotherapy. N Engl J Med 314: 182

    Article  PubMed  CAS  Google Scholar 

  46. Wirostko E, Johnson L, Wirostko B (1987) Crohn’s disease. Rifampin treatment of the ocular and gut disease. Hepato-gastroenterol 34: 90–93

    Google Scholar 

  47. Wu SWP, Pao CC, Chan J, Yen TSB (1991) Lack of mycobacterial DNA in Crohn’s disease tissue. Lancet 337: 174–175

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. G. Kreuzpaintner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Kölble
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Wallner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Hesterberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G. Acker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Medizinische Klinik II, Zentrum der Inneren Medizin, Klinikum der Johann-Wolfgang-Goethe-Universität, Theodor-Stern-Kai 7, 60590, Frankfurt a. M., Deutschland

    Wolfgang F. Caspary

  2. Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Hermann-Herder-Str. 11, 79104, Freiburg, Deutschland

    Manfred Kist

  3. Medizinische Klinik und Poliklinik, Innere Medizin II, Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Martin Zeitz

Rights and permissions

Reprints and permissions

Copyright information

© 1994 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kreuzpaintner, G., Kölble, R., Wallner, A., Hesterberg, R., Acker, G. (1994). Morbus Crohn: Eine „slow bacterial“-Infektion? — Der,,klassische“ Weg der Ursachenforschung. In: Caspary, W.F., Kist, M., Zeitz, M. (eds) Ökosystem Darm VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85187-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85187-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-58548-0

  • Online ISBN: 978-3-642-85187-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation