Zusammenfassung
Verwirrend vieleUrsachen werden mit wechselnder Intensität diskutiert. Sie reichen von einer psychosomatischen Krankheit bis zu einer Infektionskrankheit (Abb. 1). Mit großer Sicherheit ausgeschieden sind psychische und Ernährungsfaktoren. Eine genetische Prädisposition ist bewiesen. Die kürzlich beschriebene Vaskulitis [43] wurde bisher nicht reproduziert. Eine primäre Störung der Immunregulation erscheint unwahrscheinlich. Viren konnten bisher nicht nachgewiesen werden.
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Literatur
Afdhal NH, Long A, Lennon J, Crowe J, O’Donoghue DP (1991) Controlled trial of antimycobacterial therapy in Crohn’s disease. Clofazimine versus placebo. Dig Dis Sci 36: 449X–453
Best WR, Becktel JM, Singleton JW, Kern FJr. (1976) Development of a Crohns’s disease activity index. National cooperative Crohn’s disease study. Gastroenterology 70: 439–444.
Burnham WR, Lennard-Jones, JE, Stanford JL, Bird RG (1978) Mycobacteria as a possible cause of inflammatory bowel disease. Lancet ii: 693–696
Cellier C, De Benhouwer H, Faucheron JL, Carbonnel F, Berger A, Barbier JP, Portaels F (1993) Mycobacterium paratuberculosis, and avium subsp. silvaticum DNA cannot be detected in Crohn’s disease tissues. Gastroenterology 104: A678
Chiodini RJ, van Kruiningen HJ, Merkal RS (1984) Ruminant paratuberculosis (Johne’s disease): the current status and future prospects. Cornell Vet 74: 218–262
Chiodini RJ, van Kruiningen HJ, Merkal RS, Thayer WR Jr, Coutu JA (1984) Characteristics of an unclassified mycobacterium species isolated from patients with Crohn’s disease. J Clin Microbiol 20: 966 –971
Chiodini RJ, van Kruiningen HJ, Thayer WR, Coutu JA (1986) Spheroplastic phase of mycobacteria isolated from patients with Crohn’s disease. J Clin Microbiol 24: 357–363
Chiodini RJ, van Kruiningen HJ, Thayer WR, Merkal RS, Coutu JR (1984) Possible role of mycobacteria in inflammatory bowel disease. I. An unclassified Mycobacterium species isolated from patients with Crohn’s disease. Dig Dis Sci 29: 1073–1079
Colemont LJ, Pattyn SR, Michielsen PP, Pen JH, Pelckmans PA, van Maercke YM, Portaels F (1988) Acid-fast bacilli in Crohn’s disease. Lancet is 294–295
Coloe PJ, Wilks, CR, Lightfoot D, Tosolini FA (1986) Isolation of a Mycobacterium sp. resembling M. paratuberculosis from the bowel tissue of a patient with Crohn’s disease. Aust Microbiol 7: 188
Crohn BB, Ginzburg L, Oppenheimer GD (1932) Regional ileitis. A pathologic and clinical entity. JAMA 99: 1323–1329
Dalziel TK (1913) Chronic interstitial enteritis. Br Med J 2: 1068–1070
Das PK, Blaauwgeers JLG, Slob AW, Yong SL, Rambukkana A (1989) Mycobacterial antibody (Myc-Ab) response in relation to Crohn’s disease (CD). Gastroenterology 96: A 111
Elliott PR, Lennard-Jones JE, Burnham WR, White S, Stanford JL (1980) Further data on skin testing with mycobacterial antigens in inflammatory bowel disease. Lancet ii: 483–484
Fidler HM, Thurrell W, Johnson N McI, Rook GAW, McFadden JJ (1994) Specific detection of Mycobacterium paratuberculosis DNA associated with granulomatous tissue in Crohn’s disease. Gut 35: 506 –510
Gitnick G, Collins J, Beaman B, Brooks D, Arthur M, ImaedaT, Palieschesky M (1989) Preliminary report on isolation of mycobacteria from patients with Crohn’s disease. Dig Dis Sci 34: 925– 932
Graham DY, Markesich DC, Yoshimura HH (1987) Mycobacteria and inflammatory bowel disease. Results of culture. Gastroenterology 92: 436–442
Green EP, Tizard MLV, Moss MT, Thompson J, Winterbourne DJ, McFadden JJ, Hermon-Taylor J (1989) Sequence of characteristics of IS900, an insertion element identified in a human Crohn’s disease isolate of Mycobacterium paratuberculosis. Nucleic Acids Res 17: 9063–9073
Haagsma J, Mulder CJJ, Eger A, Tytgat GNJ (1991) Mycobacterium paratuberculosis isolated from patients with Crohn’s disease. Preliminary Dutch results. Acta Endosc 21: 255–260
Haga Y (1986) Mycobacteria in Crohn’s disease. Jpn J Gastroenterol 23: 2325–2333
Hampson SJ, Parker MC, Saverymuttu SH, Joseph AE, McFadden J-JP, Hermon-Taylor J (1989)Quadruple antimycobacterial chemotherapy in Crohn’s disease: results at 9 months of a pilot study in 20 patients. Aliment Pharmacol Ther 3: 343–352
Järnerot G, Rolny P, Wickbom G, Alemayehu G (1989) Antimycobacterial therapy ineffective in Crohn’s disease after a year. Lancet is164–165
Kelleher D, O’Brien S, Weir DG (1982) Preliminary trial of clofazimine in chronic inflammatory bowel disease. Gut 23: A 449
Kohn A, Prantera C, Mangiarotti R, Luzi C, Andreoli A (1992) Antimycobacterial therapy and Crohn’s disease: a randomized placebo controlled trial. Gastroenterology 102: A 647
Koltun WA, Bloomer MM, Kauffman GL, Localio AR, Zarkower A (1993) Mycobacteria other than paratuberculosis may play a role in Crohn’s disease. Gastroenterology 104: A726
McClure HM, Chiodini RJ, Anderson DC, Swenson RB, Thayer WR, Coutu JA (1987) Mycobacterium paratuberculosis infection in a colony of stumptail macaques ( Macaca arctoides ). J Infect Dis 155: 1011–1019
van Patter W (1952) Pathology and pathogenesis of regional enteritis. PhD thesis, Univ Minnesota, USA
Picciotto A, Gesu GP, Schito GC, Testa R, Varagona G, Celle G (1988) Antimycobacterial chemotherapy in two cases of inflammatory bowel disease. Lancet is 536–537
Prantera C, Bothamley G, Levenstein S, Mangiarotti R, Argentieri R (1989) Crohn’s disease and mycobacteria: two cases of Crohn’s disease with high anti-mycobacterial antibody levels cured by dapsone therapy. Biomed Pharmacother 43: 295–299
Rachmilewitz D (1989) Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative colitis: a randomised trial. Br Med J 298: 82–86
Relman DA, Schmidt TM, MacDermott RP, Falkow S (1992) Identification of the uncultured bacillus of Whipple’s disease. N Engl J Med 327: 293–301
Reynolds DS (1963) The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J Cell Biol 17: 208–212
Rook GAW, Stanford JL (1992) Slow bacterial infections or autoimmunity2 Immunol Today 13: 160 –164
Rosenberg WMC, Bell JI (1991) Mycobacterium paratuberculosis DNA cannot be detected in Crohn’s disease tissues. Gastroenterology 100: A611
Rutgeerts P, Vantrappen G, van Isveldt J, Geboes K (1988) Rifabutin therapy in patients with recurrent Crohn’s disease after ileocolonic resection. Gastroenterology 94: A 391
Sanderson JD, Moss MT, Tizard MLV, Hermon-Taylor J (1992) Mycobactrium paratuberculosis DNA in Crohn’s disease tissue. Gut 33: 890–896
Schultz MG, Rieder HL, Hersh T, Riepe S (1987) Remission of Crohn’s disease with antimycobacterial chemotherapy. Lancet ii: 1391–1392
Shaffer JL, Hughes S, Linaker BD, Baker RD, Turnberg LA (1984) Controlled trial of rifampicin and ethambutol in Crohn’s disease. Gut 25: 203–205
Spurr AR (1969) A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 26: 31–43
Swift GL, Srivastava ED, Stone R et al. (1994) Controlled trial of anti-tuberculous chemotherapy for two years in Crohn’s disease. Gut 35: 363–368
Thayer WR, Coutu JA, Chiodini RJ, van Kruiningen HJ (1988) Use of rifabutin and streptomycin in the therapy of Crohn’s disease. Gastroenterology 94: A 458
Visuvanathan S (1990) The characterisation of pleomorphic acid fast organisms isolated from patients with inflammatory bowel disease. MD thesis, Univ London
Wakefield AJ,Sawyerr AM,Dhillon AP,Pittilo RM,Rowles PM,Lewis AAM,Pounder RE(1989) Pathogenesis of Crohn’s disease: multifocal gastrointestinal infarction. Lancet ii: 1057–1062
Ward M, McManus JPA (1975) Dapsone in Crohn’s disease. Lancet is 1236–1237
Warren JB, Rees HC, Cox TM (1986) Remission of Crohn’s disease with tuberculosis chemotherapy. N Engl J Med 314: 182
Wirostko E, Johnson L, Wirostko B (1987) Crohn’s disease. Rifampin treatment of the ocular and gut disease. Hepato-gastroenterol 34: 90–93
Wu SWP, Pao CC, Chan J, Yen TSB (1991) Lack of mycobacterial DNA in Crohn’s disease tissue. Lancet 337: 174–175
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Kreuzpaintner, G., Kölble, R., Wallner, A., Hesterberg, R., Acker, G. (1994). Morbus Crohn: Eine „slow bacterial“-Infektion? — Der,,klassische“ Weg der Ursachenforschung. In: Caspary, W.F., Kist, M., Zeitz, M. (eds) Ökosystem Darm VI. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85187-2_15
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