Skip to main content
SpringerLink
Log in

Das Lungenemphysem und die obstruktive Atemwegserkrankung: Ursache — Diagnostik — Prävention

  • Conference paper
Verhandlungen der Deutschen Gesellschaft für Innere Medizin

Part of the book series: Verhandlungen der Deutschen Gesellschaft für Innere Medizin ((VDGINNERE,volume 96))

  • 67 Accesses

Zusammenfassung

Das Lungenemphysem ist charakterisiert durch eine irreversible Destruktion des Lungenparenchyms distal der Bronchioli terminales mit gleichzeitiger Überblähung der Lunge. Die eigentlichen Ursachen der Gewebszerstörung sind lange unklar geblieben.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Badwey JA, Karnovsky ML (1970) Active oxygen species and the functions of phagocytic leukocytes. Annu Rev Biochem 49:695–726.

    Article  Google Scholar 

  2. Baugh JC, Travis J (1976) Human leukocyte granule elastase: rapid isolation and characterization. Biochemistry 15:836–841.

    Article  PubMed  CAS  Google Scholar 

  3. Baumstark JS (1967) Studies on the elastase-serum protein interaction. Arch Biochem Biograph 118:619–630.

    Article  CAS  Google Scholar 

  4. Beatty K, Bieth J, Travis J (1980) Kinetics of association of sevine proteinases with native and oxidized alpha-1-antitrypsin inhibitor and alpha-l-antichymotrypsin. J Biol Chem 255:3931–3934.

    PubMed  CAS  Google Scholar 

  5. Bergin CJ, Müller NL, Miller RR (1986) CT in the quantitative assessment of emphysema. J Thorac Imaging 1:94–103.

    Article  PubMed  CAS  Google Scholar 

  6. Carp H, Janoff A (1978) Possible mechanism of emphysema in smokers. In vitro suppression of serum elastase-inhibitory capacity by fresh cigarette smoke and its prevention by antioxidations. Am Rev Respir Dis 118:617–621.

    PubMed  CAS  Google Scholar 

  7. Carp H, Janoff A (1979) In vitro suppression of serum elastase-inhibitory capacity by reactive oxygen species generated by phagocytosing polymorphonuclear leukocytes. J Clin Invest 63:793–797.

    Article  PubMed  CAS  Google Scholar 

  8. Carp H, Miller F, Hoidal R, Janoff A (1982) Potential mechanisms of emphysema: alpha 1 proteinase inhibitor recovered from lungs of cigarette smokers contains oxidised methionine and has decreased elastase inhibitory capacity. Arch Natl Acad Sci USA 779:2041–2045.

    Article  Google Scholar 

  9. Eriksson S (1965) Studies in alpha-1-antitrypsin deficiency. Acta Med Scand 177[Suppl 432]: 1–85.

    Google Scholar 

  10. Flenley DC (1990) Diagnosis and follow-up of emphysema. Eur Respir J 3[Suppl 9]:5s–8s.

    Google Scholar 

  11. Foster WL, Pratt PC, Roggli VL, Godwin JD, Halvorsen RA, Putman CE (1986) Centrilobular emphysema: CT-pathogenetic correlation. Radiology 159:27–32.

    PubMed  Google Scholar 

  12. Gadek JE, Hunninghake GW, Fells GA, Zimmermann RL, Crystal RG (1981) Production of connective tissue-specific proteases by human alveolar macrophages is constitutive (nonregulatable). Am Rev Respir Dis 123:55.

    Google Scholar 

  13. Gadek JE, Klein HG, Holland PU, Crystal RG (1981) Replacement therapy of alpha-1-antitrypsin deficiency — reversal of protease-antiprotease imbalance within the alveolar structures of PiZ subjects. J Clin Invest 68:1158–1165.

    Article  PubMed  CAS  Google Scholar 

  14. Gross P, Fritzer EA, Tolker E, Babyak MA, Kaschak M (1965) Experimental emphysema. Its production with papain in normal and silicotic rats. Arch Environ Health 11:50–58.

    PubMed  CAS  Google Scholar 

  15. Heck LW, Morihara K, McRae WB, Miller EJ (1986) Specific cleavage of human type III and IV collagens by Pseudomonas alonginosa elastase. Infect Immun 51:115–118.

    PubMed  CAS  Google Scholar 

  16. Hunninghake GW, Gadek JE, Kawanami O, Ferrans VJ, Crystal RG (1979) Inflammatory and immune processes in the human lung in health and disease: evaluation by bronchoalveolar lavage. Am J Pathol 97:149–205.

    PubMed  CAS  Google Scholar 

  17. Janoff A (1985) Elastase and emphysema. Current assessment of protease-antiprotease hypothesis. Am Rev Respir Dis 132:417–433.

    PubMed  CAS  Google Scholar 

  18. Janoff A, Sloan B, Weinbaum G (1977) Experimental emphysema induced with purified human neutrophil elastase: tissue localization of the instilled protease. Am Rev Respir Dis 115:461–478.

    PubMed  CAS  Google Scholar 

  19. Janoff A, Carp H, Laurent P, Raja L (1983) The role of oxidative processes in emphysema. Am Rev Respir Dis 127:S31–S38.

    PubMed  CAS  Google Scholar 

  20. Janus ED, Phillips NT, Carrel RW (1985) Smoking lung function, and alpha-1-antitrypsin function. Lancet I:152–154.

    Article  Google Scholar 

  21. Johnson D, Travis J (1979) The oxidative inactivation of human alpha-1-proteinase inhibitor. J Biol Chem 254:4022–4026.

    PubMed  CAS  Google Scholar 

  22. Karnovsky ML, Badwey JA (1983) Determinants of the production of active oxygen species by granulocytes and macrophages. J Clin Chem Clin Biochem 21:545–553.

    PubMed  CAS  Google Scholar 

  23. Kerr JS, Chae CK, Bey RA, Riley DJ (1984) Hyperoxia causes degradation of lung collagen in tissue slices. Am Rev Respir Dis 129:319A.

    Google Scholar 

  24. Kowalski J, Rasche B, Ulmer WT (1977) Alpha-1-Antitrypsinmangel und Lungenemphysem (Lungenfunktion und Verlauf). Prax Pneumol 31:950–959.

    CAS  Google Scholar 

  25. Kuwano K, Matsuba K, Ikeda T, et al. (1990) The diagnosis of mild emphysema. Correlation of computed tomography and pathology scores. Am Rev Respir Dis 141:169–178.

    PubMed  CAS  Google Scholar 

  26. Larsson C (1978) Natural history and life expectancy in severe alpha-1-antitrypsin deficiency. Acta Med Scand 206:345–351.

    Google Scholar 

  27. Laurell CD, Eriksson S (1963) The electrophoretic alpha-1-globuline pattern of serum in alpha-1-antitrypsin deficiency. Scand J Clin Lab Invest 15:132–140.

    CAS  Google Scholar 

  28. Mailänder A, Marek W, Schött D, Ulmer WT (1990) Das intrathorakale Gasvolumen. Reversibler und irreversibler Anteil in ihrer Bedeutung für die Lungenfunktionsdiagnostik (im Druck).

    Google Scholar 

  29. Morihara K, Tsuzuki H, Harada M, Iwata T (1984) Purification of human plasma alpha-1-proteinase inhibitor and its inactivation by Pseudomonas aeruginosa elastase. J Biochem (Tokyo) 93:795–804.

    Google Scholar 

  30. Reilly CF, Travis J (1980) The degradation of human lung elastin by neutrophil proteinase. Biochem Biophys Acta 621:147–157.

    PubMed  CAS  Google Scholar 

  31. Schmidt EW, Rasche B, Ulmer WT, et al. (1988) Replacement therapy for alpha-1-protease-inhibitor deficiency in PiZ subjects with chronic obstructive lung disease. Am J Med 84(6a):63–69.

    PubMed  CAS  Google Scholar 

  32. Schmidt EW, Derendorf H, Rasche B, Möllmann HW (1989) Klinische und pharmakokinetische Untersuchungen zur Substitution von alpha-1-Proteasen-Inhibitor bei Patienten mit homozygotem alpha-l-Proteasen-Inhibitor-Mangel und Lungenemphysem. Atemw Lungenkr 15:479–488.

    Google Scholar 

  33. Senior RM, Tegner H, Kuhn C, Ohlsson K, Starcher BC, Pierce JA (1977) The induction of pulmonary emphysema with leucocyte elastase. Am Rev Respir Dis 116:469–475.

    PubMed  CAS  Google Scholar 

  34. Snider GL, Lucey EC, Christensen TG (1984) Emphysem and bronchial secretory cell metaplasia induced in hamsters by human neutrophil products. Am Rev Respir Dis 129:155–160.

    PubMed  CAS  Google Scholar 

  35. Stockley RA (1984) Measurement of soluble proteins in lung secretions. Thorax 39:241–247.

    Article  PubMed  CAS  Google Scholar 

  36. Stockley RA, Mistry M, Bradwell AR, Burnett D (1979) A study of plasma proteins in the sol phase of sputum from patients with chronic bronchitis. Thorax 34:777–782.

    Article  PubMed  CAS  Google Scholar 

  37. Travis J, Salvesen GS (1983) Human plasma proteinase inhibitors. Annu Rev Biochem 52:655–709.

    Article  PubMed  CAS  Google Scholar 

  38. Wächter E, Hochstrasser K, Albrecht GJ (1984) Inaktivierung des Inhibitorsystems der Atmungsorgane: exogene und endogene Einflüsse. Atemw Lungenkr 10:613–615.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Klinik, Berufsgenossenschaftliche Krankenanstalten „Bergmannsheil“, Universitätsklinik, Bochum, Deutschland

    E. W. Schmidt

Authors
  1. E. W. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag, Berlin Heidelberg

About this paper

Cite this paper

Schmidt, E.W. (1990). Das Lungenemphysem und die obstruktive Atemwegserkrankung: Ursache — Diagnostik — Prävention. In: Verhandlungen der Deutschen Gesellschaft für Innere Medizin. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84317-4_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-84317-4_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-53256-9

  • Online ISBN: 978-3-642-84317-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation