Skip to main content

Cancer Detection by Immunoscintigraphy, Selection, and Clinical Application of Monoclonal Anti-CEA Antibodies and Their F (ab′)2 or Fab Fragments

  • Conference paper

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 100))

Abstract

The concept of using radiolabeled antibodies capable of localizing the hidden cancer cells [14] has been revitalized by the discovery of the monoclonal antibody (Mab) technology [9]. This discovery has not yet led to the identification of absolutely specific tumor antigens, but has allowed the selection of perfectly homogeneous Mabs which bind with high affinity to tumor-associated markers.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Buchegger F, Haskell CM, Schreyer M, Scazziga BR, Randin S, Carrel S, Mach J-P (1983) Radio-labeled fragments of monoclonal anti-CEA antibodies for localization of human colon carcinoma grafted into nude mice. J Exp Med 158: 413–427

    Article  PubMed  CAS  Google Scholar 

  2. Buchegger F, Schreyer M, Carrel S, Mach J-P (1984) Monoclonal antibody identify a CEA cross-reacting antigen of 95 KD (NCA-95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 KD. Int J Cancer 33: 643–649

    Article  PubMed  CAS  Google Scholar 

  3. Burtin P, Quan PC, Sabine MC (1975) Nonspecific cross-reacting antigen as a marker for human polymorphs, macrophages and monocytes. Nature 255: 714

    Article  PubMed  CAS  Google Scholar 

  4. Delaloye B, Bischof-Delaloye A, Buchegger F, von Fliedner V, Grob FR, Volant J-C, Pettavel J, Mach J-P (1986) Detection of Colorectal Carcinom by Emission-computerized Tomography after injection of 123I-labeled Fab or F(ab’)2 Fragments from Monoclonal Anti-Carcinoembryonic Antigen Antibodies. J Clin Invest Vol.77, January 1986 (in press)

    Google Scholar 

  5. Gold P, Freedman SO (1965) Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J Exp Med 121: 439

    Article  PubMed  CAS  Google Scholar 

  6. Granowska M, Shepherd J, Britton KE, Ward B, Mather S, Taylor-Papadimitriou J, Epenetos AA, Carroll MJ, Nimmon CC, Hawkins LA, Slevin M, Flatman W, Horne T, Burchell J, Durbin H, Bodmer W (1984) Ovarian cancer: diagnosis using 1231 monoclonal antibody in comparison with surgical findings. Nuclear Med Commun 5: 485–499

    Article  CAS  Google Scholar 

  7. Hammersmith Oncology Group and Imperial Cancer Research Fund (1983) Antibody-guided irradiation of malignant lesions: three cases illustrating a new method of treatment. Lancet I: 1441–1443

    Google Scholar 

  8. Haskell CM, Buchegger F, Schreyer M, Carrel S, Mach J-P (1983) Monoclonal antibodies to carcinoembryonic antigen: ionic strength as a factor in the selection of antibodies for immunoscintigraphy. Cancer Res 43: 3857–3864

    PubMed  CAS  Google Scholar 

  9. Köhler G, Milstein C (1975) Continous cultures of fused cells secreting antibody of predefined specificity. Nature 256: 455–457

    Article  Google Scholar 

  10. Larson SM, Carrasquillo JA, Krohn KA, Brown JP, McGuffin RW, Ferens JM, Graham MM, Hill LD, Beaumier PL, Hellström KE, Hellström I (1983) Localization of 131-I-labeled p97-specific Fab fragments in human melanoma as a basis for radiotherapy. J Clin Invest 72: 2101–2114

    Article  PubMed  CAS  Google Scholar 

  11. Leichner PK, Klein JL, Siegelman SS, Ettinger DS, Order SE (1983) Dosimetry of I-131 labeled anti-ferritin in hepatoma: specific activities in the tumor and liver. Cancer Treat Rep 67: 647–6518

    PubMed  CAS  Google Scholar 

  12. Mach J-P, Pustaszeri G (1972) Carcinoembryonic antigen (CEA): demonstration of partial identity between CEA and a normal glycoprotein. Immunochemistry 9: 10–31

    Article  Google Scholar 

  13. Mach J-P, Carrel S, Merenda C, Sordat B, Cerottini J-C (1974) In vivo localisation of radiolabeled antibodies to carcinoembryonic antigen in human colon carcinoma grafted into nude mice. Nature 248: 704–706

    Article  PubMed  CAS  Google Scholar 

  14. Mach J-P, Buchegger F, Forni M, Ritschard J, Berche C, Lumbroso JD, Schreyer M, Girardet Ch, Accolla RS, Carrel S (1981) Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy. Immunol Today 2: 239–249

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin · Heidelberg

About this paper

Cite this paper

Grob, JP. et al. (1986). Cancer Detection by Immunoscintigraphy, Selection, and Clinical Application of Monoclonal Anti-CEA Antibodies and Their F (ab′)2 or Fab Fragments. In: Herfarth, C., Schlag, P., Hohenberger, P. (eds) Therapeutic Strategies in Primary and Metastatic Liver Cancer. Recent Results in Cancer Research, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82635-1_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-82635-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-82637-5

  • Online ISBN: 978-3-642-82635-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics