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Formation and Removal of Methylated Nucleosides in Nucleic Acids of Mammalian Cells

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Modified Nucleosides and Cancer

Abstract

This chapter compares the formation, turnover, and possible functions of methylated nucleosides present in nucleic acids under normal conditions and after exposure to alkylating agents. No attempt is made to provide a totally comprehensive review of the occurrence and biochemistry of such products. Many recent reviews have covered portions of this field, and to summarize such a broad area is probably impossible and unlikely to be useful. More relevantly, it is also outside the limited capabilities of the author. Attention, therefore, is concentrated on the methylation of DNA by certain carcinogens which may have environmental importance and on selected references to certain areas of the immense biochemical literature relating to normal cellular methylations.

This research was supported by grant CA 18137 from the National Cancer Institute, DHEW

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Authors and Affiliations

  1. Department of Physiology and Specialized Cancer Research Center, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA, 17033, USA

    A. E. Pegg

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  1. A. E. Pegg
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Editors and Affiliations

  1. Zentrallaboratorium für Mutagenitätsprüfung, Deutschen Forschungsgemeinschaft, Breisacher Strasse 33, D-7800, Freiburg, Germany

    Gisela Nass

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© 1983 Springer-Verlag Berlin • Heidelberg

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Pegg, A.E. (1983). Formation and Removal of Methylated Nucleosides in Nucleic Acids of Mammalian Cells. In: Nass, G. (eds) Modified Nucleosides and Cancer. Recent Results in Cancer Research/Fortschritte der Krebsforschung/Progrès dans les recherches sur Ie cancer, vol 84. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81947-6_3

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  • DOI: https://doi.org/10.1007/978-3-642-81947-6_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81949-0

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