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Follow-Up of a Randomized Trial for Oat Cell Carcinoma Evaluating the Efficacy of Peripheral Intravenous Nutrition (PIVN) as Adjunct Treatment

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Adjuvant Therapies of Cancer

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 80))

Summary

A randomized trial was initiated to compare the effects of peripheral i.v. nutrition (PIVN)-associated chemotherapy (adriamycin, vincristine, VP-16-213, and cyclophosphamide) versus a chemotherapy control group in patients with oat cell lung carcinoma. Thirty-nine evaluable patients were randomized. The test group included 19 patients, whereas 20 were followed in the control group. PIVN was scheduled each day the patient underwent chemotherapy. Each patient received 1,550 kcal day which included 10% glucose, 20% lipids, and amino acids which may or may not have been mixed in the same infusion bottle. The results show ten PIVN patients presently in complete remission at the end of three courses of treatment, compared to nine over the same time period in the chemotherapy control group. Thirty-three percent of patients are still alive after 15 months after the beginning of treatment. There was no significant difference in either general health or side effects, frequency or duration of complete remission, or survival time. After 1 year of treatment, 8 of 19 PIVN patients are still in complete remission, compared to 7 of 20 patients in the control group.

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Author information

Authors and Affiliations

  1. Centre Paul Lamarque, Department of Immuno-Chemotherapy, Hôpital Saint-Eloi, F-34033, Montpellier Cedex, France

    B. Serrou, D. Cupissol, R. Plagne, P. Boutin, P. Chollet, Y. Carcassonne & F. B. Michel

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  1. B. Serrou
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  2. D. Cupissol
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  3. R. Plagne
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  4. P. Boutin
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  5. P. Chollet
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  6. Y. Carcassonne
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  7. F. B. Michel
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Editor information

Editors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, 14-16 Avenue Paul-Vaillant-Couturier, F-94800, Villejuif, France

    G. Mathé

  2. Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, I-20133, Milan, Italy

    G. Bonadonna

  3. Health Science Center Department of Internal Medicine Section of Hematology and Oncology Tucson, The University of Arizona, 85724, AZ, USA

    S. Salmon

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© 1982 Springer-Verlag Berlin · Heidelberg

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Serrou, B. et al. (1982). Follow-Up of a Randomized Trial for Oat Cell Carcinoma Evaluating the Efficacy of Peripheral Intravenous Nutrition (PIVN) as Adjunct Treatment. In: Mathé, G., Bonadonna, G., Salmon, S. (eds) Adjuvant Therapies of Cancer. Recent Results in Cancer Research, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81685-7_39

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  • DOI: https://doi.org/10.1007/978-3-642-81685-7_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81687-1

  • Online ISBN: 978-3-642-81685-7

  • eBook Packages: Springer Book Archive

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