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Medikamentöse Einflüsse auf das Skelett aus pathologischer Sicht

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Book cover Osteologie aktuell VIII

Zusammenfassung

Das Skelett unterliegt physiologisch einem ständigen Umbau, der der Strukturerhaltung und der Regulation des Kalziumstoffwechsels dient. Dieser Knochenumbau zeigt sich histomorphologisch durch eine Aktivierung von Osteoblasten für einen Knochenanbau und von Osteoklasten für einen Knochenabbau. Er wird physiologisch durch eine Reihe von Signalsubstanzen gesteuert. Medikamente und andere therapeutische Maßnahmen wirken sich auf die Struturen des Skeletts aus, was wir histologisch an einer Knochenresorption (Resorptionslakunen mit Osteoklasten) oder an einem Knochenanbau (Anbaufronten mit Osteoblasten) erkennen. Bei Mineralisationsstörungen beobachten wir verbreiterte Osteoidsäume (Osteoidose). Bei der Diagnostik müssen die radiologischen Strukturveränderungen (Röntgenbild, CT, Szintigraphie, NRI) mit berücksichtigt werden. Bei systemischen Skeletterkrankungen wird eine Beckenkammbiopsie für die histologische Untersuchung benutzt; bei lokalisierten Läsionen ist eine gezielte Biopsie erforderlich.

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Author information

Authors and Affiliations

  1. Pathologisches Institut, Universität Freiburg, Albertstraße 19, D-79104, Freiburg i.Br., Deutschland

    C. P. Adler & H. E. Schaefer

Authors
  1. C. P. Adler
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  2. H. E. Schaefer
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Editor information

Editors and Affiliations

  1. Institut für Radiologische Diagnostik, Klinikum Großhadern, Marchioninistraße 15, D-81377, München, Germany

    Maximilian Reiser  & Andreas Heuck  & 

  2. Orthopädische Klinik, Sigmund-Freud-Str. 25, D-53225, Bonn, Germany

    K. Joachim Münzenberg

  3. Anatomisches Institut der Universität, Joseph-Stelzmann-Str. 9, D-50931, Köln, Germany

    Benno Kummer

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© 1994 Springer-Verlag Berlin Heidelberg

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Adler, C.P., Schaefer, H.E. (1994). Medikamentöse Einflüsse auf das Skelett aus pathologischer Sicht. In: Reiser, M., Heuck, A., Münzenberg, K.J., Kummer, B. (eds) Osteologie aktuell VIII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78676-1_44

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  • DOI: https://doi.org/10.1007/978-3-642-78676-1_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-57497-2

  • Online ISBN: 978-3-642-78676-1

  • eBook Packages: Springer Book Archive

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