Abstract
All eukaryotic cells use heterotrimeric GTP-binding proteins, G-proteins, in their responses to extracellular signals. Our current understanding of the transduction processes mediated by these proteins began with the discovery that GTP regulates glucagon binding to its receptor (Rodbell et al. 1971b), and that the nucleotide is required for hormone stimulation of adenylyl cyclase (Rodbell et al. 1971a). Those observations led to the discovery of the family of G-proteins and their widespread involvement in many different signal transduction pathways (Birnbaumer 1990; Gilman 1984). The responses of cells to individual signals using G-proteins are probably complex and seem to depend upon a large number of factors related to the diversity of G-proteins within the cell and their mechanism(s) of activation. The identification of these mechanisms has often involved studies of receptor regulation of adenylyl cyclase activity.
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Hildebrandt, J.D. (1993). Hormonal Inhibition of Adenylyl Cyclase by αi and βγ, αi orβγ, αi and/or βγ. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_27
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DOI: https://doi.org/10.1007/978-3-642-78345-6_27
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