Abstract
The generation and selection of B lymphocytes in the bone marrow involves a complex series of differentiation steps, molecular interactions with local stromal cells and the influences of both short range and systemic growth factors (Osmond 1986,1990; Kincade 1989,1991). Normal regulation of B lymphopoiesis requires a balance between these various processes. Dysregulations, possibly predisposing to oncogenesis, may result from perturbations at a number of different points in the chain of regulatory events.
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© 1992 Springer-Verlag Berlin Heidelberg
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Osmond, D.G., Jacobsen, K., Fauteux, L., Valenzona, H., Rico-Vargas, S. (1992). Multiple Steps in the Regulation and Dysregulation of B-Cell Precursors in the Bone Marrow: c-myc Expression, In Vivo Effects of Interleukins 1 and 7, and Stromal Cell Interactions. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_6
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DOI: https://doi.org/10.1007/978-3-642-77633-5_6
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