Abstract
It has been well established by several groups that IL-6 is overproduced in patients with Multiple Myeloma (MM) and that this cytokine is an essential growth factor of myeloma cells both in vitro and in vivo (1–5). Most investigators also agree now that IL-6 is produced mainly by bone-marrow stromal cells (1, 6). The aim of this report was to summarize our recent results concerning the mechanisms of IL-6 production control by the bone-marrow environment and the different means of neutralizing IL-6 activity in vitro and in vivo.
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References
Klein B, Zhang X G, Jourdan M, Content J, Houssiau F, Aarden L A, Piechaczyk M, and Bataille R (1989). Paracrine rather than autocrine regulation of myelomacell growth and differentiation by interleukin-6. Blood 73: 517.
Kawano M, Hirano T, Matsuda T, Taga T, Horii Y, Iwato k, Asaoku H, Tang B, Tanabe O, Tanaka H, Kuramato A, and Kishimoto T (1988). Autocrine generation and requirement of BSF-2/IL-6 for human Multiple Myelomas. Nature 332: 83.
Anderson K C, Jones R M, Morimoto C, Leavitt P, and Barut B A, (1989). Response patterns of purified myeloma cells to hematopoietic growth factors. Blood 73: 1915.
Nilsson K, Jernberg H, and Pettersson M (1990). IL-6 as a growth factor for human myeloma cells — a short overview. Current Topics of Microbiology and Immunology, vol. 166 F. Melchers, and M Potter (eds). Springer-Verlag, Berlin-Heidelberg, p 3..
Klein B, Wijdenes J, Zhang X G, Jourdan M, Boiron J M, Brochier J, Liautard J, Merlin M, Clement C, Morel-Foumier B, Lu Z Y, Mannoni B, Sany J, and Bataille R (1991). Murine Anti-lnterleukin — 6 Monoclonal Antibody Therapy for a Patient With Plasma Cell Leukemia. Blood 5: 1198.
Portier M, Rajzbaum G, Zhang X G, Attal M, Rusalen C, Wijdenes J, Mannoni P, Maraninchi D, Piechaczyk M, Bataille R, and Klein B (1991). In vivo interleukin-6 gene expression in the tumoral environment in multiple myeloma. Eur J Immunol 21: 1759.
Carter A, Merchav S, Silvian-Draxler I, (1990) The role of interleukin-1 and tumor necrosis factor-α in human multiple myeloma. Br Haematol J 74: 424.
Cozzolino F, Torcia M, Aldinucci D, (1989). Production of interleukin-1 by bonemarrow myeloma cells. Blood 74: 380.
Dürkop Horst, Latza Ute, Hummel Michael, Eitelbach Florin, Seed Brian, and Stein Harald (1982). Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for hodgkin’s disease. Cell 68:421.
Gibbons R, Martinez O, Matli M, Heinzel F, Bernstein M, and Warren R (1990). Recombinant IL-4 inhibits IL-6 Synthesis by Adherent Peripheral Blood Cells In Vitro. Lymphokine Res. 93:283.
Waage A, Slupphaug G, and Shalaby R (1990). Glucocorticoids inhibit the production of IL-6 from monocytes, endothelial cells and fibroblasts. Eur J Immunol, 20: 2439–2443.
Bataille R, Jourdan M, Zhang X G, and Klein B (1989). Serum Levels of lnterleukin-6, a Potent Myeloma Cell Growth Factor, as a Reflect of Disease Severity in Plasma Cell Dyscrasias. 84: 2008.
Bataille R, Boccadoro M, Klein B, Durie B, Pileri A. (1992). C-Reactive Protein and B-2 Microglobulin Produce a Simple and Powerful Myeloma Staging System. Blood, In press.
Reibnegger G, Krainer M, Herold M, Heinz L, Wachter H, and Heinz H (1991). Predictive Value of lnterleukin-6 and Neopterin in Patients with Multiple Myeloma. Cancer Res 51: 6250.
Gearing DP, Comeau MR, Friend DJ, Gimpel D, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, Ziegler SF, Cosman D. (1992) The IL-6 Signal Transducer, gp 130. An Oncostatin M Receptor and Affinity Converter for the LIF Receptor. Science 255:1434.
Plotz PH, Kimberly RP, Guyer RL, and Segal DM. (1979). Stable model immune complexes produced by bivalent affinity labeling haptens: in-vivo survival. Mol Immunol, 16: 721.
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© 1992 Springer-Verlag Berlin Heidelberg
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Klein, B., Lu, Z.Y., Gaillard, J.P., Harousseau, J.L., Bataille, R. (1992). Inhibiting IL-6 in Human Multiple Myeloma. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_29
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DOI: https://doi.org/10.1007/978-3-642-77633-5_29
Publisher Name: Springer, Berlin, Heidelberg
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