Abstract
The proliferation of an abnormal clone of plasma cells can produce a wide variety of human diseases such as monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), active multiple myeloma (MM), amyloidosis, non-Hodgkin’s lymphoma, Waldenström’s macroglobulinemia, and osteosclerotic myeloma (POEMS syndrome). For the patient to be optimally managed, the clinician must correctly classify the patient as MGUS, SMM, active MM, and relapsed MM (RMM). Patients with MGUS have a small population of monoclonal plasma cells; however, a recent study of 202 patients with MGUS followed for a median of 22 years found that only 19% (39/202) developed multiple myeloma [4]. Patients with SMM meet the criteria for MM but have a normal complete blood count and serum chemistries and can have a prolonged stable course without the need for chemotherapy [5]. Patients with MM and RMM have active disease and require chemotherapy.
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© 1992 Springer-Verlag Berlin Heidelberg
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Witzig, T.E., Kyle, R.A., Greipp, P.R. (1992). Circulating Peripheral Blood Plasma Cells in Multiple Myeloma. In: Potter, M., Melchers, F. (eds) Mechanisms in B-Cell Neoplasia 1992. Current Topics in Microbiology and Immunology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77633-5_23
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DOI: https://doi.org/10.1007/978-3-642-77633-5_23
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