Shock-Induced Disturbances in Cellular Metabolism and Membrane Function

Zusammenfassung

Shock may be characterized as circulatory disturbance that lasts long enough and is severe enough to induce significant metabolic and functional cellular disturbances [14, 17]. The cellular response of the trauma patient to acute physical injury are, however, considerably more complex, as outlined in Fig. 1. At the site of injury the integrity of tissue cells is initially mainly endangered by direct mechanical trauma, while later systemic hypotension due to external and internal losses of body fluids will further impair tissue perfusion and oxygenation and enhance local cellular injury [1].