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Regional Cerebral Blood Flow in Binswanger’s Disease

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Cerebral Ischemia and Dementia

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Abstract

In 1894, the term “encephalitis subcorticalis chronica progressiva” was introduced by Otto Binswanger to refer to a noninflammatory disease of the cerebral white matter. It was detected in eight patients who presented a slow progression of mental deterioration, which he attributed to reduced cerebral blood flow resulting from arteriosclerosis [4] Until recently Binswanger’s disease or subcortical arteriosclerotic encephalopathy (SAE) was considered to be a rare disease, but in recent years, thanks to modern neuroimaging techniques such as cranial computed tomography (CCT) [13,29,30,32,33] and magnetic resonance imaging (MRI) [5,10,14,34], this disorder has been detected with greater frequency. The typical clinical picture includes a constellation of insidiously progressive deterioration of memory, mood, and cognition; focal neurological signs and symptoms with bilateral pyramidal tract signs; less often, pseudobulbar palsy; and finally, gait and sphincter disturbances [12,23,24].

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Author information

Authors and Affiliations

  1. Department of Neurology, University Hospital Bonn, Sigmund-Freud-Str. 25, W-5300, Bonn 1, Germany

    K. Broich, A. Hartmann, B. Naaz, C. Dettmers & M. Fric

  2. Department of Neuroradiology, University Hospital Bonn, Sigmund-Freud-Str. 25, W-5300, Bonn 1, Germany

    L. Solymosi

Authors
  1. K. Broich
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  2. A. Hartmann
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  3. L. Solymosi
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  4. B. Naaz
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  5. C. Dettmers
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  6. M. Fric
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Editor information

Editors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Str. 25, W-5300, Bonn 1, Germany

    Alexander Hartmann

  2. Physiologisches Institut der Universität, Im Neuenheimer Feld 326, W-6900, Heidelberg, Germany

    Wolfgang Kuschinsky

  3. Abt. für Pathochemie und Allg. Neurochemie, Pathologisches Institut der Universität, Im Neuenheimer Feld 220-221, W-6900, Heidelberg, Germany

    Siegfried Hoyer

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© 1991 Springer-Verlag Berlin Heidelberg

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Broich, K., Hartmann, A., Solymosi, L., Naaz, B., Dettmers, C., Fric, M. (1991). Regional Cerebral Blood Flow in Binswanger’s Disease. In: Hartmann, A., Kuschinsky, W., Hoyer, S. (eds) Cerebral Ischemia and Dementia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76208-6_34

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  • DOI: https://doi.org/10.1007/978-3-642-76208-6_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-76210-9

  • Online ISBN: 978-3-642-76208-6

  • eBook Packages: Springer Book Archive

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