Abstract
Man’s thinking has always been channelled by the work and thoughts of his predecessors. Attempts to break away are difficult, and the path rocky. Roy and Sherrington, in 1890, first formulated a rational hypothesis about regulation of blood flow to the brain: “The chemical products of cerebral metabolism contained in the lymph which bathes the walls of the arterioles of the brain can cause variations of calibre of the cerebral vessels. In this reaction the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity”[42].
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References
Alvarez WC (1946) Cerebral arteriosclerosis with small commonly unrecognized apoplexies. Geriatrics 1:159–166
Alzheimer A (1899) Beitrag zur Pathologischen Anatomie der Seelenstörungen des Griesenalters. Neurol Zentralbl 18:95–96
Astrup J (1982) Energy-requiring cell functions in the ischemic brain. Their critical supply and possible inhibition in protective therapy. J Neurosurg 56:482–497
Astrup J, Siesjo BK, Symon L (1981) Thresholds in cerebral ischemia — the ischemic penumbra. Stroke 12:723–725
Binswanger O (1894) Die Abgrenzung des allgemeinen progressiven Paralysie. Bed Klin Wochenschr 31:1103–1105, 1137–1139, 1180–1186
Blennow K, Wallin A, Fredman P, Karlsson I, Gottfries CG, Svennerholm L (1990) Blood-brain barrier disturbance in patients with Alzheimer’s disease is related to vascular factors. Acta Neurol Scand 81:323–326
Branston NM, Symon L, Crockard HA et al. (1974) Relationship between the cortical evoked potential and local cortical blood flow following acute middle cerebral artery occlusion in the baboon. Exp Neurol 45:195–208
Brun A, Englund E (1986) A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol 19:253–262
Castaigne P, Lhermitte F, Buge A, Escourelle R, Hauw JJ, Lyon-Caen O (1981) Paramedian thalamic and midbrain infarction: clinical and neuropathological study. Ann Neurol 10: 127–148
Chimowitz MI, Awad IA, Furlan AJ (1989) Periventricular lesions on MRI — facts and theories. Stroke 20:963–967
Delpha P, Meyer E, Zatorre R et al. (1989) Metabolic and neuropsychological correlates of periventricular lucencies. J Cerebr Blood Flow Metab 9 (Suppl 1):5569
del Ser T, Bermejo F, Portera A, Arrendondo JM, Bouras C, Constantinidis J (1990) Vascular dementia. A clinicopathological study. J Neurol Sci 96:1–17
De Reuck JL (1971) The human periventricular arterial blood supply and the anatomy of cerebral infarctions. Eur Neurol 5:321–334
Dunne JW, Leedman PJ, Edis RH (1986) Inobvious stroke: a cause of delirium and dementia. Aust NZ J Med 16:771–778
Fields WS (1973) Cerebral arteriosclerosis: a “non-cause” of dementia. In: Meyer JS, Lechner H, Reivich M et al. (eds) Cerebrovascular disease. Sixth International Conference. Thieme, Stuttgart
George AE, DeLeon MJ, Gentes CI et al. (1986) Leukoencephalopathy in normal and pathologic aging. Am J Neuroradiol 7:561–566
Gray F, Dubas F, Roullet E, Escourolle R (1985) Leukoencephalopathy in diffuse hemorrhagic cerebral amyloid angiopathy. Ann Neurol 18:54–59
Guberman A, Stuss D (1983) The syndrome of bilateral paramedian thalamic infarction. Neurology 33:540–546
Hachinski VC, Lassen NA, Marshall J (1974) Multi-infarct dementia. A cause of mental deterioration in the elderly. Lancet 207–210
Hachinski VC, Potter P, Merskey H (1987) Leuko-araiosis. Arch Neurol 44:21–23
Heiss W-D (1983) Flow thresholds of functional and morphological damage of brain tissue. Stroke 14:329–331
Heiss W-D, Rosner G (1983) Duration versus severity of ischemia as critical factors of cortical cell damage. In: Reivich M, Hurtig HI (eds) Cerebrovascular Diseases. Thirteenth Research (Princeton) Conference. Raven, New York, pp 225–233
Heiss W-D, Hayakawa T, Waltz AG (1976) Cortical neuronal function during ischemia. Arch Neurol 33:813–820
Hendrie HC, Farlow MR, Austrom MG, Edwards MK, Williams MA (1989) Foci of increased T2 signal intensity on brain MR scans of healthy elderly subjects. AJNR 10:703–707
Ishii N, Nishihara Y, Imamura T (1986) Why do frontal lobe symptoms predominate in vascular dementia with lacunes? Neurology 36:340–345
Jones TH, Morawetz RB, Crowell RM, Marcoux FW, Fitzgibbon SJ, De Girolami U, Ojemann RG (1982) Thresholds of focal cerebral ischemia in awake monkeys. J Neurosurg 54:773–782
Katz DI, Alexander MP, Mandell AM (1987) Dementia following strokes in the mesencephalon and diencephalon. Arch Neurol 44:1127–1133
Kinkel WR, Jacobs L, Polachini I, Bates V, Heffner RR (1985) Subcortical arteriosclerotic encephalopathy (Binswanger’s disease): computed tomographic, nuclear magnetic resonance and clinical correlations. Arch Neurol 42:951–959
Kirkpatrick JB, Hayman LA (1987) White matter lesions in MRI of clinically healthy brains of elderly subjects: possible pathologic basis. Radiology 162:509–511
Kraepelin E (1883) Compendium der Psychiatric Barth, Leipzig
Leonardi A, Gandolfo C, Caponnetto C, Arata L, Vecchia R (1985) The integrity of the blood-brain barrier in Alzheimer’s type and multi-infarct dementia evaluated by the study of albumin and IgG in serum and cerebrospinal fluid. J Neurol Sci 67:253–261
Lou HC, Edvinsson L, MacKenzie ET (1987) The concept of coupling blood flow to brain function: revision required? Ann Neurol 22:289–297
Marcoux FW, Morawetz RB, Crowell RM, DeGirolami U, Halsey JH (1982) Differential regional vulnerability in transient focal cerebral ischemia. Stroke 13:339–346
Marshall VG, Bradley WG, Marshall CE, Bhoopat T, Rhodes RH (1988) Deep white matter infarctions: correlation of MR imaging and histopathologic findings. Radiology 167:517–522
Morawetz RB, De Girolami U, Ojemann RG, Marcoux FW, Crowell RM (1978) Cerebral blood flow determinated by hydrogen clearance during middle cerebral artery occlusion in unanesthetized monkeys. Stroke 9:143–149
Meissner I, Shapir S, Kokmen E, Stein S (1987) The paramedian diencephalic syndrome: a dynamic phenomenon. Stroke 18:380–385
Naheedy MH, Gupta SR, Young JC et al. (1985) Periventricular white matter changes and subcortical dementia. Clinical, neuropsychological, radiological, and pathological correlation. AJNR 6:468
Raine CS (1976) Neurocellular anatomy. In: Albers RW, Siegel GJ, Katzman R, Agranoff BW (eds) Basic neurochemistry, 2nd edn. Little, Brown, Boston, pp 5–33
Rao SM, Mittenberg W, Bernardin L, Haughton V, Leo GJ (1989) Neuropsychological test findings in subjects with leuko-araiosis. Arch Neurol 46:40–44
Rezek DL, Morris JC, Fulling KH, Gado MH (1986) Periventricular white matter lucencies in SDAT and healthy aging. Neurology 36 (Suppl 1):263–264
Roth M (1971) Classification and aetiology in mental disorders of old age: some recent developments. In: Recent developments in psychogeriatrics, pp 1–18 (Br J Psychiatry Spec Publ no 6)
Roy CW, Sherrington CS (1890) On the regulation of the blood supply of the brain. J Physiol (Lond) 11:85–108
Scheibel AB, Duong T, Tomiyasu U (1987) Denervation microangiopathy in senile dementia, Alzheimer type. Alzheimer Dis Assoc Disord 1:19–37
Steingart A, Hachinski VC, Lau C et al. (1987) Cognitive and neurologic findings in subjects with diffuse white matter lucencies on CT scan. Arch Neurol 44:32–35
Sulkava R, Erkinjuntti T (1987) Vascular dementia due to cardiac arrhythmias and systemic hypotension. Acta Neurol Scand 76:123–128
Tomlinson BE, Henderson G (1976) Some quantitative cerebral findings in normal and demented old people. In: Terry RD, Gershon S (eds) Neurobiology of aging. Raven, New York, pp 183–204
Tomlinson BE, Blessed G, Roth M (1970) Observations on the brains of demented old people. J Neurol Sci 11:205–242
Victor M, Angevine JB, Mancall EL, Fisher CM (1961) Memory loss with lesions of hippocampal formation. Report of a case with some remarks on the anatomical basis of memory. Arch Neurol 5:244–263
Wallin A, Alafuzoff I, Carlsson A, Eckernas S-A, Gottfries CG, Karlsson I, Svennerholm L, Winblad B (1989) Neurotransmitter deficits in a non-multiinfarct category of vascular dementia. Acta Neurol Scand 79:397–406
Wallin A, Blennow K (in press) The pathogenetic basis of multi-infarct dementia. Alzheimer Dis Assoc Disord
Wallin A, Blennow K, Fredman P, Gottfries CG, Karlsson I, Svennerholm L (1990) Blood brain barrier function in vascular dementia. Acta Neurol Scand 81:318–322
Wallin A, Gottfries CG, Karlsson I, Svennerholm L (1989) Decreased myelin lipids in Alzheimer’s disease and vascular dementia. Acta Neurol Scand 80:319–323
Wertham F, Wertham F (1934) The brain as an organ. Macmillan, New York
Xie Y, Mies G, Hossmann K-A (1989) Ischemic threshold of brain protein synthesis after unilateral carotid artery occlusion in gerbils. Stroke 20:620–626
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Hastak, S.M., Hachinski, V.C. (1991). Multiinfarct and Microinfarct Dementia. In: Hartmann, A., Kuschinsky, W., Hoyer, S. (eds) Cerebral Ischemia and Dementia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76208-6_26
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DOI: https://doi.org/10.1007/978-3-642-76208-6_26
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