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Antidepressants and Neuroleptics in Treatment and Prophylaxis of Schizoaffective Psychoses

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Abstract

Over the past 20 years, the schizoaffective psychoses have become an extremely interesting and intensively researched area (Marneros and Tsuang 1986). Despite variations in the definition of this diagnostic group, attempts have been made to investigate genealogical, genetic, biological, and case-specific aspects of schizo-affective psychoses and to classify them by placing them either among the schizophrenic psychoses (Detre and Jarecki 1971), among the affective psychoses (Pope and Lipinski 1978), or in a separate diagnostic category between these two broad areas of endogenous psychoses (Klein et al. 1981).

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References

  • Alexander PE, van Kammen DP, Bunney WR (1979) Antipsychotic effects of lithium in schizophrenia. Am J Psychiatry 136: 283–287

    PubMed  CAS  Google Scholar 

  • Angst J (1961) A clinical analysis of the effects of tofranil in depression. Psychopharmacologia 2: 381–407

    Article  PubMed  CAS  Google Scholar 

  • Angst J, Weis P, Grof P, Baastrup PC, Schou M (1970) Lithium prophylaxis in recurrent affective disorders. Br J Psychiatry 116: 604–613

    Article  PubMed  CAS  Google Scholar 

  • Arnold OH, Collard J, Deniker P, Ginestet D, Hippius H, Itil TM, Labhardt F, Leeds AA, Montanini R, Morozov G, Simon P, Villeneuve A (1970) Definition and classification of neuroleptics. Mod Probl Pharmacopsychiatry 5: 141–147

    PubMed  CAS  Google Scholar 

  • Aronoff MS, Epstein RS (1970) Factors associated with poor response to lithium carbonate: a clinical study. Am J Psychiatry 127: 472–480

    PubMed  CAS  Google Scholar 

  • Avery D, Winokur G (1977) The efficacy of electroconvulsive therapy and antidepressants in depression. Biol Psychiatry 12: 507–523

    PubMed  CAS  Google Scholar 

  • Bandelow B, Rüther E (1989) Neuroleptika in der Behandlung schizoaffektiver Psychosen. In: Marneros A (ed) Schizoaffektive Psychosen. Diagnostik, Therapie und Prophylaxe. Springer, Berlin Heidelberg New York pp 149–158

    Google Scholar 

  • Berner P (1987) Neuroleptika zur Behandlung schizoaffektiver Psychosen. In: Pichot P, Möller HJ (eds) Neuroleptika, Rückschau 1952–1986 — Künftige Entwicklungen. Springer, Berlin Heidelberg New York, pp 103–110

    Google Scholar 

  • Biederman J, Lerner Y, Belmaker RH (1979) Combination of lithium carbonate and haloperidol in schizoaffective disorder. Arch Gen Psychiatry 36: 327–333

    PubMed  CAS  Google Scholar 

  • Bobon DP (1973) Classification and terminology of psychotropic drugs. Pharmacopsychiatry 6: 1–12

    Article  CAS  Google Scholar 

  • Braden W, Fink EB, Qualls CB, Ho CK, Samuels WO (1982) Lithium and chlorpromazine in psychotic patients. Psychiatry Res 7: 69–81

    Article  PubMed  CAS  Google Scholar 

  • Brockington IF, Kendell RE, Kellett JM, Curry SH, Wainwright S (1978) Trials of lithium, chlorpromazine and amitriptyline in schizoaffective patients. Br J Psychiatry 133: 162–168

    Article  PubMed  CAS  Google Scholar 

  • Brockington IF, Kendell RE, Wainwright S (1980) Depressed patients with schizophrenic or paranoid symptoms. Psychol Med 10: 665–675

    Article  PubMed  CAS  Google Scholar 

  • Carman JS, Bigelow LB, Wyatt RJ (1981) Lithium combined with neuroleptics in chronic schizophrenic and schizoaffective patients. J Clin Psychiatry 42: 124–128

    PubMed  CAS  Google Scholar 

  • Detre TP, Jarecki HP (1971) Modern psychiatric treatment. Lippincott, Philadelphia

    Google Scholar 

  • Dunner DL, Fieve RR (1978) The lithium ion: its impact on diagnostic practice. In: Akiskal HS, Wells WL (eds) Psychiatric diagnosis: exploration of biological predictors. SP Medical and Scientific Books, New York, pp 233–246

    Google Scholar 

  • Forssman H, Walinder J (1970) Lithium as an aid in psychiatric diagnostics. Acta Psychiatr Scand (Suppl) 219: 59–66

    Article  Google Scholar 

  • Freyhan FA (1957) Psychomotilität, extrapyramidale Syndrome and Wirkungsweisen neuro-leptischer Therapie (Chlorpromazin, Reserpin, Prochlorperazin). Nervenarzt 28: 504–509

    PubMed  CAS  Google Scholar 

  • Goodnick PJ, Meltzer HY (1983) Lithium treatment of schizomania and mania. Presented at the Annual Meeting of the American Psychiatric Association, May 1–6, 1983

    Google Scholar 

  • Goodnick, Pi, Meltzer HY (1984) Treatment of schizoaffective disorders. Schizophr Bull 10: 30–48

    PubMed  CAS  Google Scholar 

  • Gottfries CS (1968) Effect of lithium salts on various kinds of psychiatric disorders. Acta Psychiatr Scand (Suppl) 203: 157–167

    Article  CAS  Google Scholar 

  • Greenblatt M, Grosser GH, Wechsler H (1962) A comparative study of selected antidepressant medications and ECT. Am J Psychiatry 119: 144–153

    PubMed  CAS  Google Scholar 

  • Hirsch SR (1983) The causality of depression in schizophrenia. Br J Psychiatry 142:624–625

    Google Scholar 

  • Hirschkowitz J, Casper R, Garver DL, Chang S (1980) Lithium response in good prognosis schizophrenia. Am J Psychiatry 137: 916–920

    Google Scholar 

  • Hofmann G, Kremser M, Katschnig H, Scheiber V (1970) Prophylaktische Lithiumtherapie bei manisch-depressivem Krankheitsgeschehen and bei Legierungspsychosen. Int Pharmacopsychiatry 4: 187–193

    Google Scholar 

  • Hordern A, Holt NF, Burt CG, Gordon WF (1963) Amitriptyline in depressive states. Br J Psychiatry 109: 815–825

    Article  PubMed  CAS  Google Scholar 

  • Hullin RP, McDonald R, Allsopp MNE (1975) Further report on prophylactic lithium in recurrent affective disorders. Br J Psychiatry 126: 281–284

    Article  PubMed  CAS  Google Scholar 

  • Johnson G (1970) Differential response to lithium carbonate in manic depressive and schizoaffective disorders. Dis New Syst 31: 613–615

    CAS  Google Scholar 

  • Johnson G, Gershon S, Hekimian Li (1968) Controlled evaluation of lithium and chlorpromazine in the treatment of manic states: an interim report. Compr Psychiatry 9:563–573

    CAS  Google Scholar 

  • Johnson G, Gershon S, Burdock EI, Floyd A, Hekimian LJ (1971) Comparative effects of lithium and chlorpromazine in the treatment of acute manic states. Br J Psychiatry 119: 267–276

    Article  PubMed  CAS  Google Scholar 

  • Kantor SJ, Glassman AH (1977) Delusional depressions: natural history and response to treatment. Br J Psychiatry 131: 351–360

    Article  PubMed  CAS  Google Scholar 

  • Klein DF (1968) Importance of psychiatric diagnosis in prediction of clinical drug effect. Psychopharmacology 13: 359–368

    Article  CAS  Google Scholar 

  • Klein DF, Rüther E (1983) Klinisch bedeutsame Wechselwirkungen der Psychopharmaka. In: Langer G, Heimann H (eds) Psychopharmaka. Grundlagen and Therapie. Springer, Vienna New York, pp 617–635

    Google Scholar 

  • Klein DF, Gittelman R, Quitkin F, Rifkin A (1981) Diagnosis and drug treatment of psychiatric disorders. Williams and Wilkins, Baltimore

    Google Scholar 

  • Marneros A, Tsuang MT (eds) (1986) Schizoaffective psychoses. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Mattes JA, Nayak D (1984) Lithium vs fluphenazine for prophylaxis in mainly schizophrenic schizoaffectives. Biol Psychiatry 19: 445–449

    PubMed  CAS  Google Scholar 

  • McConaghy N (1970) Actuarial v. clinical prediction. Br J Psychiatry 117: 122

    Article  Google Scholar 

  • Megrabyan, AA, Khachaturyan AM, Amadyan MG, Burnazyan GA (1979) The treatment of schizoaffective psychoses with lithium carbonate. Zh Eksp Klin Med 19 (4): 54–58

    Google Scholar 

  • Menter RE, Mandel MR (1979) The treatment of psychotic major disorder with drugs and electroconvulsive therapy. J Nerv Ment Dis 12: 726–733

    Google Scholar 

  • Möller HJ (1987a) Konsequenzen aus der klinischen Psychopharmakologie für die nosologische und syndromatologische Klassifikation funktioneller psychischer Störungen. In: Simhandl C, Berner P, Luccioni H, Alf C (eds) Klassifikationsprobleme in der Psychiatrie. Medizinisch-pharmazeutische Verlagsgesellschaft, Purkersdorf, pp 163–188

    Google Scholar 

  • Möller HJ (1987b) Indikation und Differentialindikation der neuroleptischen Langzeitmedikation. In: Pichot P, Möller HJ (eds) Neuroleptika, Rückschau 1952–1986 — Künftige Entwicklungen. Springer, Berlin Heidelberg New York, pp 63–79

    Google Scholar 

  • Möller HJ, Morin C (1989) Behandlung schizodepressiver Syndrome mit Antidepressiva. In: Marneros A (ed) Schizoaffektive Psychosen. Diagnose, Therapie und Prophylaxe. Springer, Berlin Heidelberg New York, pp 159–178

    Google Scholar 

  • Möller HJ, von Zerssen D (1986) Depression in schizophrenia. In: Burrows GD, Norman TR, Rubinstein G (eds) Handbook of studies in schizophrenia. Part I. Elsevier, Amsterdam, pp 183–191

    Google Scholar 

  • Möller HJ, Schmid-Bode W, Cording-Tömmel C, Wittchen HU, Zaudig M, von Zerssen D (1988) Psychopathological and social outcome in schizophrenia vs affective/schizoaffective psychoses and prediction of poor outcome in schizophrenia: Results from a 5–8 years follow-up. Acta Psychiatr Scand 77: 379–389

    Article  PubMed  Google Scholar 

  • Möller HJ, Hohe-Schramm M, Cording-Tömmel C, Schmidt-Bode W, Wittchen HU, Zaudig M, von Zerssen D (1989) The classification of functional psychoses and its implications for prognosis. Br J Psychiatry 154: 467–472

    Article  PubMed  Google Scholar 

  • Nedopil N, Rüther E (1983) Psychopharmakotherapie bei schizoaffektiven Psychosen. In: Langer G, Heimann H (eds) Psychopharmaka. Grundlagen und Therapie. Springer, Vienna New York, pp 467–476

    Google Scholar 

  • Nelson IC, Bowers MB (1978) Delusional unipolar depression. Description and drug response. Arch Gen Psychiatry 35: 1321–1328

    Google Scholar 

  • Overall JE, Hollister LE, Meyer F (1964) Imipramine and thioridazine in depressed and schizophrenic patients: Are there specific antidepressant drugs? JAMA 189: 605–608

    PubMed  CAS  Google Scholar 

  • Overall JE, Hollister LE, Johnson M (1966) Nosology of depression and differential response to drugs. JAMA 195: 946–948

    Article  PubMed  CAS  Google Scholar 

  • Overall JE, Hollister LE, Shelton J (1969) Broad-spectrum screening of psychotherapeutic drugs: thiothixene as an antipsychotic and antidepressant. Clin Pharmacol Ther 10: 36–43

    PubMed  CAS  Google Scholar 

  • Paykel ES (1977) Response to treatment and depressive classification. In: Burrows GD (ed) Handbook of studies on depression. Excerpta Medica, Amsterdam, pp 21–47

    Google Scholar 

  • Perris C (1978) Morbidity suppressive effect of lithium carbonate in cycloid psychosis. Arch Gen Psychiatry 35: 328–331

    Google Scholar 

  • Pöldinger W, Sieberns S (1983) Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate. Neuropsychobiology 10: 131–136

    Google Scholar 

  • Pope HG, Lipinski JF (1978) Diagnosis in schizophrenia and manic-depressive illness. Arch Gen Psychiatry 35: 811–828

    PubMed  Google Scholar 

  • Pope HG, Lipinski JF, Cohen BM, Axelrod DT (1980) “Schizoaffective disorder”: an invalid diagnosis? A comparison of schizoaffective disorder, schizophrenia, and affective disorder. Am J Psychiatry 137:921–927

    PubMed  Google Scholar 

  • Prien RF, Caffey EM, Klett CJ (1972a) A comparison of lithium carbonate and chlorpromazine in the treatment of excited schizoaffectives. Arch Gen Psychiatry 27: 182–189

    PubMed  CAS  Google Scholar 

  • Prien RF, Caffey EM, Klett CJ (1972b) Comparison of lithium carbonate and chlorpromazine in the treatment of mania. Arch Gen Psychiatry 26: 146–153

    PubMed  CAS  Google Scholar 

  • Prien RF, Caffey EM, Klett CJ (1973) Prophylactic efficacy of lithium carbonate in manic-depressive illness. Arch Gen Psychiatry 28: 337–341

    PubMed  CAS  Google Scholar 

  • Prien RF, Caffey EM, Klett CJ (1974) Factors associated with treatment success in lithium carbonate prophylaxis. Arch Gen Psychiatry 31: 189–192

    PubMed  CAS  Google Scholar 

  • Prusoff BA, Williams DH, Wiesman MM, Astrachan BA (1979) Treatment of secondary depression in schizophrenia. Arch Gen Psychiatry 36: 569–575

    PubMed  CAS  Google Scholar 

  • Puech AJ, Lecrubier Y, Simon P (1984) Pharmacological classification of benzamides. Acta Psychiatr Scand (Suppl) 311: 139–145

    Article  CAS  Google Scholar 

  • Raskin A, Schulterbrandt JG, Reating N, Chase C, McKeon JJ (1970) Differential response to chlorpromazine, imipramine, and placebo. A study of subgroups of hospitalized depressed patients. Arch Gen Psychiatry 23: 164–173

    Google Scholar 

  • Rice D (1956) The use of lithium salts in the treatment of manic states. J Ment Sci 102:604–611

    PubMed  CAS  Google Scholar 

  • Rifkin A, Quitkin F, Klein DF (1975) Akinesia, a poorly recognized drug induced extrapyramidal disorder. Arch Gen Psychiatry 32: 672–674

    Google Scholar 

  • Robertson MM, Trimble MR (1982) Major tranquilizers used as antidepressants. A review. J Affective Disord 4: 173–193

    Google Scholar 

  • Rosenthal NE, Rosenthal LN, Stallone F, Dunner DL, Fieve RR (1980) Toward the validation of RDC schizoaffective disorder. Arch Gen Psychiatry 37: 804–810

    PubMed  CAS  Google Scholar 

  • Sarantidis D, Waters B (1981) Predictors of lithium prophylaxis effectiveness. Prog Neuropsychopharmacol 5: 507–510

    Article  PubMed  CAS  Google Scholar 

  • Shopsin B, Johnson G, Gershon S (1970) Neurotoxicity with lithium: Differential drug responsiveness. Int Pharmacopsychiatry 5: 170–182

    Google Scholar 

  • Sicignano JR, Lichtenstein J (1978) Rediagnosis of schizophrenia as bipolar affective illness. Hosp Commun Psychiatry 29: 112–114

    CAS  Google Scholar 

  • Simpson GM (1969) Experiences with thioxanthenes. Mod Probl Pharmacopsychiatry 2:76–79

    Google Scholar 

  • Simpson GM, Watts TPS (1965) Antidepressant drugs. Am J Psychiatry 121: 1028–1029

    Google Scholar 

  • Simpson GM, Amin M, Angus JWS, Edwards JG, Hing Go S, Lee JH (1972) Role of antidepressants and neuroleptics in the treatment of depression. Arch Gen Psychiatry 27: 337–345

    PubMed  CAS  Google Scholar 

  • Siris SG, van Kammen DP, Docherty JP (1978). Use of antidepressant drugs in schizophrenia. Arch Gen Psychiatry 35: 1368–1377

    PubMed  CAS  Google Scholar 

  • Small JG, Kellams JJ, Milstein V, Moore J (1975) A placebo-controlled study of lithium combined with neuroleptics in chronic schizophrenic patients. Am J Psychiatry 132: 1315–1317

    PubMed  CAS  Google Scholar 

  • Smulevitch AB, Zavidovskaya GI, Igonin AL, Mikhailova NM (1974) The effectiveness of lithium in affective and schizoaffective psychoses. Br J Psychiatry 125: 65–72

    Article  PubMed  CAS  Google Scholar 

  • Spiker DG (1981) Schizoaffective disease and atypical psychosis. Psychopharmacol Bull 17: 75–78

    PubMed  CAS  Google Scholar 

  • Spiker DG, Hanin I, Perel JM, Cofsky AJ, Rossi AJ, Sorisio D (1982) Pharmacological treatment of delusional depressives. Psychopharmacol Bull 18: 184–186

    PubMed  CAS  Google Scholar 

  • Spiker DG, Weiss JC, Dealy RS, Griffin SJ, Hanin I, Neil JF, Perel JM, Rossi AJ, Soloff PH (1985) The pharmacological treatment of delusional depression. Am J Psychiatry 142: 430–436

    PubMed  CAS  Google Scholar 

  • Tress W, Haag H (1979) Vergleichende Erfahrungen mit der rezidivprophylaktischen Lithium-Langzeitmedikation bei schizoaffektiven Psychosen. Nervenarzt 50: 524–526

    PubMed  CAS  Google Scholar 

  • Van Kammen DP, Alexander PE, Bunney WE (1980) Lithium treatment in post-psychotic depression. Br J Psychiatry 136: 479–485

    Article  PubMed  Google Scholar 

  • Van Praag HM (1978) Psychotropic drugs. A guide for the practitioner. Van Gorum, Amsterdam

    Google Scholar 

  • Zall H, Therman PG, Myers JM (1968) Lithium carbonate. A clinical study. Am J Psychiatry 125: 549–555

    PubMed  CAS  Google Scholar 

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Möller, HJ. (1990). Antidepressants and Neuroleptics in Treatment and Prophylaxis of Schizoaffective Psychoses. In: Marneros, A., Tsuang, M.T. (eds) Affective and Schizoaffective Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75353-4_21

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  • DOI: https://doi.org/10.1007/978-3-642-75353-4_21

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