Abstract
Discussion on the origin and development of cancer has rapidly increased since the detection of the existence of oncogenes (for review see Kurth, 1983; Ochoa, 1985). Although carcinogenesis is assumed to be a multistep process, molecular biology has made it clear that oncogenes can contribute greatly to the development of a tumor. Normal cells of very different animals, such as worms, flies, other insects, birds, mammals, and humans contain similar oncogenes (“c-genes”). This indicates a high conservation of this set of genes, and an important function for them in growth and development, particularly in embryogenesis. Some retroviruses have appropriated oncogenes by genetic recombination from normal cells, so that retrovirus infection, introducing additional viral (and modified) oncogenes (“v-genes”) into normal cells, as well as carcinogen-mediated activation of cellular oncogenes, may both lead to increased synthesis of oncogene-encoded informational proteins that convert normal cells to cancer cells. Some of these proteins are tyrosine kinases that catalyze the phosphorylation of the tyrosine residues of proteins. They find a location within the cell membrane and may alter the surface properties of the cell; others, evidently non-enzymatic in nature, are found in the cell nucleus and may influence gene activities in general. Further possible activities of oncogene are their mutation, their transposition, or their amplification (= extra replication, i.e. increase in number). The latter phenomenon is now commonly accepted as an important factor in drug resistance (e.g., Schimke, 1984).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
W.B. Chwirot, Acta Physiol. Plant. 2, 103 (1980).
W.B. Chwirot, R.S. Dygdala, and S. Chwirot, Cytobios 44, 95 (1985a).
W.B. Chwirot, R.S. Dygdala, and S. Chwirot, Cytobios 44, 239 (1985b).
W.B. Chwirot, R.S. Dygdala, and S. Chwirot, Cytobios (1986), accepted for publica¬tions.
B. Fain, Phys. Rev. A: Gen. Phys. 24, 933, (1981).
L. Fonda, G.C. Ghirardi, and A. Rimini, Rep. Prog. Phys. 41, 587 (1978).
H. Fröhlich, Int. J. Quantum Chem. 2, 641 (1968).
L. Hayflick, Exp. Cell. Res. 23, 14 (1961).
R. Kurth, Naturwissenschaften 70, 439 (1983).
K.H. Li and F.A. Popp, Phys. Lett. 93A, 262 (1983).
K..H. Li, Rep. Prog. Phys. (1986), in press.
K.H. Li, F.A. Popp, W. Nagl, and H. Klima, in Coherent Excitations in Biological Systems, H. Fröhlich and F. Kremer, Eds., Springer, Berlin, 1983.
W. Nagl, Int. J. Cytol. 94, 21 (1985).
W. Nagl and F.A. Popp, Cytobios 37, 45 (1983).
K.L. Ngai, A.K. Rajagopal, R.W. Rendell, and S. Teitler, Phys. Rev. B: Solid State 28, 6073 (1983).
S. Ochoa, Naturwiss. Rdsch. 38, 368 (1985).
H.C. Pitot, C. Peraino, P.A. Morse, and V.R. Potter, Natl. Cancer Inst. Monogr. 13, 229 (1964).
F.A. Popp, in Electromagnetic Bio-Information, F.A. Popp, G. Becker, H.L. König, and W. Peschka, Eds., Urban & Schwarzenberg, München/Baltimore, 1979.
F.A. Popp, Biologie des Lichts, Paul Parey-Verlag, Berlin/Hamburg, 1984.
F.A. Popp, Proc. Int. Conference on Lasers ’85, Las Vegas, Nevada, 1985, The Society for Optical & Quantum Electronics USA, in press.
F.A. Popp, in Selected Papers on Selforganization and Dissipative Structures, D. Reidel Publ. Co., Dordrecht/Boston, 1986, in press.
F.A. Popp, K.H. Li, and W. Nagl, Z. Pflanzenphysiol. 114, 1 (1984).
F.A. Popp and W. Nagl, Cytobios 37, 71 (1983).
F.A. Popp and W. Nagl, Polym. Bull. 15, 89 (1986).
F.A. Popp, B. Ruth, W. Bahr, J. Böhm, P. Grass, G. Grolig, M. Rattemeyer, H.G. Schmidt, and P. Wulle, Coll. Phenom. 3, 187 (1981).
F.A. Popp and J. Slawinski, (1986), in preparation.
I. Prigogine, private communication, 1984.
M. Rattemeyer, F.A. Popp, and W. Nagl, Naturwissenschaften 68, 572 (1981).
S. Rowlands, J. Biol. Phys. 11, 117 (1983).
B. Ruth, Dissertation (Exp. Phys.), Marburg 1977.
D.H.J. Schamhart, K.W. van de Poll, and R. van Wijk, Cancer Res. 39, 1051 (1979).
D.H.J. Schamhart, A. Slawinski, and R. van Wijk, Cancer Res. (1986), in press.
R.T. Schimke, Cell 37, 705 (1984).
D. Slawinska and J. Slawinski, Photochem. Photobiol. 37, 709 (1983).
J. Slawinski and D. Slawinska, in Chemiluminescence and Bioluminescence, J. Burr, Ed., Marcel Dekker, New York, 1986.
E. B. Thompson, G.M. Tomkins, and J.F. Curren, Proc. Natl. Acad. Sci. U.S.A. 56, 296 (1966).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Nagl, W., Popp, F.A. (1987). Opposite Long-range Interactions Between Normal and Malignant Cells. In: Barrett, T.W., Pohl, H.A. (eds) Energy Transfer Dynamics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71867-0_24
Download citation
DOI: https://doi.org/10.1007/978-3-642-71867-0_24
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-17502-5
Online ISBN: 978-3-642-71867-0
eBook Packages: Springer Book Archive