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Clinical Applications of the Adenylate Cyclase System in Its Relationship to the Control of Intraocular Pressure

  • Conference paper
Book cover Glaucoma Update III

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Abstract

The regulation of cell function and cell physiology by cyclic nucleotides has been an intensive and fruitful area of research. New therapeutic strategies have been developed as a result of increased understanding of the synthesis and metabolism of cyclic AMP. Cyclic AMP is synthesized by the membrane bound enzyme complex adenylate cyclase. Hormones regulate this enzyme in a stimulatory or inhibitory manner, thus modulating the levels of intracellular cyclic AMP to elicit appropriate cellular responses. Hormone sensitive adenylate cyclase is a multisubunit enzyme system whose regulation is complex and relies on the interaction of not only hormones at receptor sites, but also the interaction of other regulatory proteins and guanine nucleotides.

Supported by USPHS Grant #EY-00785, and grants from Research to Prevent Blindness, Inc. and from Hoeehst-Roussel Pharmaceuticals, Inc.

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Authors and Affiliations

  1. New Haven, USA

    J. Caprioli & M. Sears

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  1. J. Caprioli
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  2. M. Sears
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Editors and Affiliations

  1. Joseph-Stelzmann-Straße 9, D-5000, Köln 41, Germany

    G. K. Krieglstein (Direktor der Universitäts-Augenklinik Köln) (Direktor der Universitäts-Augenklinik Köln)

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© 1987 Springer-Verlag Berlin Heidelberg

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Caprioli, J., Sears, M. (1987). Clinical Applications of the Adenylate Cyclase System in Its Relationship to the Control of Intraocular Pressure. In: Krieglstein, G.K. (eds) Glaucoma Update III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71785-7_34

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  • DOI: https://doi.org/10.1007/978-3-642-71785-7_34

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17399-1

  • Online ISBN: 978-3-642-71785-7

  • eBook Packages: Springer Book Archive

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