Abstract
Mice of the double congenic strain, B10.H-2aH-4bp/Wts (2a4b), display a high incidence of lymphoma following intense adoptive immunization with sheep erythrocytes (SRBC). The tumors which arise comprise a heterogenous group, including the UNC series of T cell lymphomas (Corley 1983), the CH series of B cell lymphomas (Lanier 1982), and a set of lymphomas which are not readily characterized as belonging to either the B cell or T cell lineage (unpublished data). Presently available data are insufficient to define the etiology of this disease, but we previously had found that heterologous anti-idiotype sera raised against the surface IgM of CHI and of CH2 each reacted with one other of the first 11 B cell lymphomas described (CH9 and CH5, respectively) (Arnold 1982). This suggested that a limited subset of the total normal idiotype repertoire might be expressed by CH lymphomas. We also had found that the surface immunoglobulin of CH12 was specifically reactive with an epitope present on SRBC, suggesting that adoptive immunization had led to the expansion of a subset of B cells with neoplastic potential (Arnold 1983).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arnold LW, Penneil CA, LoCascio NJ, Haughton G (1982) Cross-reactive idiotypes of murine B cell lymphomas: implications for etiology and immunotherapy. In: Vitetta ES, Fox CF (eds) B and T Cell Tumors. Academic Press, New York, p 499.
Arnold LW, LoCascio NJ, Lutz PM, Penneil CA, Klapper DG, Haughton G, (1983) Antigen-induced lymphomagenesis: identification of a murine B cell lymphoma with known antigen specificity. J Immunol 131: 2064–2068.
Bekoff MC, Levine H, Schlossman SF (1982) T cell and Ir gene regulation of expression of a cross-reactive idiotype. J Immunol 129: 1173–1180.
Bona CA, Heber-Katz E, Paul WE (1981) Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med 153: 951–967.
Bothwell ALM, Paskind M, Reth M, Imanishi-Kari T, Rajewsky K, Baltimore D (1981) Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a. variable region. Cell 24: 625–637.
Briles DE, Forman C, Hudak S, Claflin JL (1982) Anti-phosphoryl- choline antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae. J Exp Med 156: 1177–1185.
Corley RB, Arnold LW, Lutz PM, Kuhara T, White DA, Staniszewski C, Haughton G (1983) T cell lymphomas with helper T cell function. In: Parker JW, O’Brien RL (eds) Intercellular Communication in Leucocyte Function. John Wiley and Sons Ltd., Sussex, p 521.
Crews S, Griffin J, Huang H, Calame K, Hood L (1981) A single VH gene segment is correlated with the class of the antibody. Cell 25: 59–66.
Gleason K, Kohler H (1982) Regulatory idiotypes. T helper cells recognize a shared VH idiotope on phosphorylcholine-specific anti-bodies. J Exp Med 156: 539–549.
Haughton G, Lanier LL, Babcock GF, Lynes MA (1978) Antigen-induced murine B cell lymphomas. II. Exploitation of the surface idiotype as tumor specific antigen. J Immunol 121: 2358–2362.
Hood L, Loh E, Hubert J, Barstad P, Eaton B, Early P, Fuhrman J, Johnson N, Kronenberg M, Schilling J (1977) The structure and genetics of mouse immunoglobulins: an analysis of NZB myeloma proteins and sets of BALB/c myeloma proteins binding particular haptens CSH Symp Quant Biol 41: 817–836.
Lanier LL, Arnold LW, Raybourne RB, Russell S, Lynes MA, Warner NL,, Haughton G (1982) Transplantable B-cell lymphomas in B10.H-2aH-4b p/Wts mice. Immunogen 16: 367–371.
Linder E, Edgington TS (1972) Antigenic specificity of anti-erythrocyte autoantibody responses by NZB mice: identification and partial characterization of two erythrocyte surface antigens. J Immunol 108: 1615–1623.
Makela O, Karjalainen K (1977) Inherited immunoglobulin idiotypes of the mouse. Immunol Rev 34: 119–138.
Marion TN, Dzierzak EA, Lee HS, Adams RL, Janeway CA (1984) Non- dinitrophenyl-binding immunoglobulin that bears a dominant idiotype (Id460) associated with antidinitrophenyl antibody is specific for an antigen on Pasteurella pneumotropica. J Exp Med 159: 221–233.
Oudin J, Michel M (1963) A new allotype form of rabbit serum-globulins apparently associated with antibody function and specificity. CR Seances Acad Agr 257: 805.
Potter M (1972) Immunoglobulin-producing tumors and myeloma proteins of mice. Physiol Rev 52: 631–719.
Potter M (1977) Antigen-binding myeloma proteins of mice. Adv Immunol 25: 141–211.
Siekevitz M, Huang SY, Gefter ML (1981) The genetic basis of antibody production: a single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse. Eur J Immunol 13: 123–132.
Wettstein PJ, Haughton G (1974) Production, testing, and utility of double congenic strains of mice. Transplantation 17: 513–517.
Yamamoto H, Bitoh S, Torii M, Fujimoto S (1983) Idiotype-specific T lymphocytes. I. Regulation of antibody production by idiotype- specific H-2 restricted T lymphocytes. J Immunol 130: 1038–1042.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Pennell, C.A., Arnold, L.W., LoCascio, N., Lutz, P.M., Willoughby, P.B., Haughton, G. (1984). The CH Series of Murine B Cell Lymphomas: Identification of Cross-reactive Idiotypes and Restricted Antigen Specificities. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_43
Download citation
DOI: https://doi.org/10.1007/978-3-642-69860-6_43
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69862-0
Online ISBN: 978-3-642-69860-6
eBook Packages: Springer Book Archive