Abstract
Concepts involved in B cell neoplasia require a better comprehension of normal B cell activation and differentiation. Advances along these lines have been accelerated through the use of factors derived from T cell sources. T-B collaborations, previously attributed to cell to cell interaction, are mediated by these factors. T cells activated specifically or non-specifically in vitro secrete factors which induce proliferation of preactivated B cells (B cell growth factor — BCGF) or differentiation (BCDF, TRF). Within these two broad categories there is evidence that subgroups of these factors exist, possibly acting on different B cell subpopulations (Swain et al. 1983; Okada et al. 1983; Isakson et al. 1982) making T-B interactions more complex than previously thought.
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© 1984 Springer-Verlag Berlin · Heidelberg
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Mayer, L.F., Thompson, C., Fu, S.M., Kunkel, H.G. (1984). T Cell Factors Regulating B Cell Activation and Differentiation. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_15
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DOI: https://doi.org/10.1007/978-3-642-69860-6_15
Publisher Name: Springer, Berlin, Heidelberg
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