Abstract
Proliferation of normal and malignant lymphoid cells is dependent on the serum glycoprotein transferrin (Barnes and Sato. 1980). Interestingly, although serum transferrin concentrations remain consistently high (in the 4 mg/ml range), resting lymphocytes do not possess detectable transferrin receptors and do not respond to transferrin (Tormey et al. 1972; Dillner-Centerlind et al., 1979; Larrick and Cresswell, 1979), suggesting that induction and maintenance of transferrin receptor expression plays a critical role in the control of lymphoid cell proliferation. In this paper we show (1) the sequence of receptor mediated events leading to growth factor induction of transferrin receptor expression on B cells, which is followed by entry into S phase, and (2) inhibition of cell proliferation by transferrin receptor blockade, even in the presence of the uninhibited interaction of growth factor and its receptor.
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© 1984 Springer-Verlag Berlin · Heidelberg
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Neckers, L.M. (1984). Transferrin Receptors Regulate Proliferation of Normal and Malignant B Cells. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_12
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DOI: https://doi.org/10.1007/978-3-642-69860-6_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69862-0
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