Abstract
Our current knowledge of the generation, stimulation and half life of normal B cells in the immune system predicts at least three functionally distinct ways for transformation to the neoplastic state.
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References
Andersson J, Buxbaum J, Citronbaum R, Douglas S, Forni L, Melchers G, Pernis B and Scott D (1974) IgM producing tumors in the Balb/c mouse - a model for B cell maturation J Exp Med 140: 742–763
Brahim F and Osmond DG (1973) The migration of lymphocytes from bone marrow to popliteal lymph nodes demonstrated by selective bone marrow labelling with (3H) thymidine in vivo Anat Rec 175: 737–745
Cancro M and Potter M (1976) The requirement of an adherent substratum for the growth of developing plasmacytoma cells in vivo J Exp Med 144: 1554–1566
Corbel C and Melchers F (1983) The synergism of accessory cells and of soluble a factors derived from them in the activation of B cells to proliferation Immunol Rev 78: in press
Gerhard W, Hackett C and Melchers F (1983) The recognition specificity of a murine helper T cell hemagglutinin of influenza virus A/PR8/34 J Immunol 130: 2379–2385
Iscove NN and Melchers F (1978) Complete replacement of serum by albumin, transferrin and soybean lipid in cultures of lipopoly- saccharide reactive B lymphocytes J Exp Med 147:923–933
Melchers F and Andersson J (1973) Synthesis, surface deposition and secretion of immunoglobulin M in bone marrow-derived lymphocytes before and after mitogenic stimulation Transplant Rev 14: 76–130
Melchers F, Andersson J, Lernhardt W and Schreier MH (1980) H-2 unrestricted polyclonal maturation without replication of small B cells induced by antigen-activated T cell help factors Eur J Immunol 10: 679–685
Melchers F, Corbel C and Leptin M (1984) What does it take to stimulate a B cell? Progr Immunol V in press
Namba Y and Hanaoka M (1972) Immunocytology of cultured IgM-forming cells of mouse. I. Requirement of phagocytic cell factor for the growth of IgM-forming tumor cells in tissue culture J Immunol 109: 1193–1200
Potter M, Pumphrey JG and Walters JL (1972) Growth of primary plasmacytomas in the mineral oil-conditioned peritoneal environment J Natl Cancer Inst 49: 305–308
Potter M (1977) Antigen binding myeloma proteins of mice Adv Immunol 25: 141–210
Reichert RA, Gallatin WM, Weisman IL and Butcher EC (1983) Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation J Exp Med 157: 813–827
Sprent J (1977) Recirculating lymphocytes. In: The lymphocyte - Structure and Function, Part I, ed. JJ Marchalonis, Marcel Dekker Inc New York and Basel 5: 43–111
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© 1984 Springer-Verlag Berlin · Heidelberg
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Melchers, F. (1984). Multiple Steps in the Transformation of Normal B Cells Towards Neoplasia. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_11
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DOI: https://doi.org/10.1007/978-3-642-69860-6_11
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-69862-0
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