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Acetylcholine

  • Chapter
Antiepileptic Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 74))

Abstract

It is generally accepted that transmitters and modulators play a key role in epilepsy and that they are involved in attack initiation, spread, and termination. Thus, the altered synaptic availability of some excitatory and inhibitory messengers could represent an essential bridge between nerve cell physiology and pathology. To date, scientists dealing with epilepsy have focused their attention on the possible role played by the better known putative transmitters, like monoamines, gamma-aminobutyric acid (GABA), and acetylcholine (ACh) (Maynert et al. 1975; Karkzmar 1979). Following the development of new experimental models, such as kindling, the value of ACh in the field of epileptogenesis has recently increased dramatically (Mc Namara et al. 1980; Girgis 1981).

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Authors
  1. C. Bianchi
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  2. L. Beani
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Editors and Affiliations

  1. Laboratorium für Pharmakologie und Toxikologie Fachbereich Veterinärmedizin, Freie Universität Berlin, Koserstraße 20, D-1000, Berlin 33, Germany

    Hans-Hasso Frey

  2. Abteilung für Neurologie, Klinikum Charlottenburg, Spandauer Damm 130, D-1000, Berlin 19, Germany

    Dieter Janz

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© 1985 Springer-Verlag Berlin Heidelberg

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Bianchi, C., Beani, L. (1985). Acetylcholine. In: Frey, HH., Janz, D. (eds) Antiepileptic Drugs. Handbook of Experimental Pharmacology, vol 74. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69518-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-69518-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

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