Zusammenfassung
Folsäuremangelsyndrome und hämatologische Veränderungen sind in ihrem kausalen Zusammenhang sichergestellt. Für neurologische Erkrankungen und Folsäuremangel aber werden ursächliche Zuordnungen noch immer diskutiert. In der Literatur findet man zunehmend Berichte über Einzelfälle und Fallgruppen (Robertson et al. 1971; Pincus et al. 1972; Ahmed 1972; Fehling et al. 1974; Manzoor u. Runcie 1976; Botez et al. 1976, 1977, 1978; Strachan u. Henderson 1967; Freeman et al. 1976). Demenzsyndrome, subakute kombinierte spinale Strangdegenerationen und periphere Neuropathien sind beschrieben. Fälle mit kongenitalen Störungen des Folsäurestoffwechsels kommen vor, entwickeln ausgeprägte neurologisch-psychiatrische Syndrome und geben Hinweise für einen Kausalzusammenhang (Luhby et al. 1961; Lanzowsky et al. 1969; Arakawa 1970; Erbe 1975; Sue 1976).
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Literatur
Ahmed M (1972) Neurological disease and folate deficiency. Br Med J I:181
Arakawa T (1971) Congenital defects in folate utilization. Am J Med 48:594–598
Botez MI, Cadotte M, Beaulieu R, Pichette LP, Pison C (1976) Neurological disorders responsive to folic acid therapy. Can Med Assoc J 115:217–221
Botez MI, Fontaine T, Botez T, Bachevalier J (1977) Folate-responsive neurological and mental disorders: Report of 16 cases. Eur Neurol 16:230—246
Botez MI, Peyronnard JM, Bachevalier J, Charron L (1978) Polyneuropathy and folate deficiency. Arch Neuro l35:581–584
Erbe RW (1975) Inborn errors of folate metabolism. N Engl J Med 293:753–757, 807–812
Fehling C, Jägerstad M, Lindstrand K, Westesson AK (1973) The effect of anticonvulsant therapy upon absorption of folates. Clin Sci 44:595–600
Fehling C, Jägerstad M, Lindstrand K, Elmqvist D (1974) Folate deficiency and neurological disease. Arch Neurol 30:263–265
Freeman JM, Finkelstein JD, Mudd SH (1975) Folate-responsive homocystinuria and ‘schizophrenia’. N Engl J Med 292:491–96
Lanzowsky P, Erlandson ME, Bezan AI (1969) Isolated defect of folic acid absorption associated with mental retardation and cerebral calcification. Blood 34:452–165
Luhby AL, Eagle FJ, Roth E, Cooperman JM (1961) Relapsing megaloblastic anemia in an infant due to specific defect in gastrointestinal absorption of folic acid. Am J Dis Child 102:482–183
Manzoor M, Runcie J (1976) Folate-responsive neuropathy: report of 10 cases. Br Med J I:1176–1178
Pincus JH, Reynolds EH, Glaser GH (1972) Subacute combined system degeneration with folate deficiency. JAMA 221:496–497
Reynolds EH (1976) Neurological aspects of folate and vitamin B 12 metabolism. Clin Haematol 5:661–695
Reynolds EH (1979) Cerebrospinal fluid folate: clinical studies. In: Botez MI, Reynolds EH (eds) Folic acid in neurology, psychiatry and internal medicine. Raven Press, New York, pp 195–203
Robertson DM, Dinsdale HB, Campbell RJ (1971) Subacute combined degeneration of the spinal cord. No association with vitamin B12 deficiency. Arch Neurol 24:203–209
Spector R (1979) Cerebrospinal fluid folate and the blood-brain barrier. In: Botez MI, Reynolds EH (eds) Folic acid in neurology, psychiatry and internal medicine. Raven Press, New York, pp 187–194
Strachan RW, Henderson JG (1967) Dementia and folate deficiency. Quart J Med 142:189–204
Sue PC (1976) Congenital folate deficiency. N Engl J Med 294:1128
Walters T (1967) Congenital megaloblastic anemia responsive to N-formyltetrahydrofoloc acid administration. J Pediatr 70:686–687
Wells DG, Casey HJ (1967) Lactobacillus casei CSF folate activity. Br Med J III:834–836
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© 1984 Springer-Verlag Berlin Heidelberg
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Sluga, E., Neumann, E. (1984). Folsäureuntersuchungen bei Neuropathien. In: Gerstenbrand, F., Mamoli, B. (eds) Metabolische und entzündliche Polyneuropathien. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69351-9_10
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DOI: https://doi.org/10.1007/978-3-642-69351-9_10
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