Abstract
The term gene ceased to be well defined with the detection of intervening sequences or introns which interrupt the base pair runs in DNA coding for the amino acid sequences of one and the same polypeptide chain. Such coding regions are now called extrons. Consequently, some “genes” have to be considered as agglomerates of scattered coding regions dispersed by genetically silent spans. Such “genes in pieces” (GILBERT, 1978) or “split genes” (CRICK, 1979) are not only found among protein genes but also genes coding for ribosomal rRNA and transfer tRNA genes (see previous reviews in this series by ZIMMERMANN, 1978, and HERZFELD and KIPER, 1979). It is quite obvious that this scattered genetic information must be put together into a continuous template for protein synthesis and this most likely already at the RNA level, since tRNA and rRNA genes also come in pieces. This putting-together is called splicing, during which the intervening sequences or introns are excised.
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Zimmermann, F.K. (1980). Function of Genetic Material. In: Progress in Botany / Fortschritte der Botanik. Progress in Botany/Fortschritte der Botanik, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67873-8_12
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