Summary
Plasma noradrenaline content may be a biochemical marker of sympathetic nerve function in man and of value in determining the pathophysiology and therapy of primary hypertension. This paper describes our findings of the concentrations of the circulatory neurohormones, adrenaline (A), noradrenaline (NA) and its metabolite normetanephrine (NMN) in normotensive volunteers and patients with primary hypertension. A and NA were measured in blood from both arterial and venous sites and NMN was determined in venous blood. Venous plasma NA and NMN, but not A, appear to be reliable markers of net sympathetic tone in man and are increased in young patients with primary hypertension. These findings may indicate an enhanced central sympathetic noradrenergic tone which is especially amenable to therapy with centrally acting alpha agonist antihypertensive drugs.
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© 1980 Springer-Verlag Berlin Heidelberg
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DeQuattro, V., Kolloch, R., Kobayashi, K., Johnston, W., Miano, L. (1980). Circulatory Neurohormones in Primary Hypertension: Probes in Etiology and Treatment. In: Philipp, T., Distler, A. (eds) Hypertension: Mechanisms and Management. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67712-0_1
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DOI: https://doi.org/10.1007/978-3-642-67712-0_1
Publisher Name: Springer, Berlin, Heidelberg
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