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Experimental Models of Arthritis in Animals as Screening Tests for Drugs to Treat Arthritis in Man

  • Chapter
Anti-Inflammatory Drugs

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 50 / 2))

Abstract

There is a growing feeling of dissatisfaction with the methods used to screen compounds for activity against arthritic diseases in man. In 1968, Spector and Willoughby alluded to “the temptation to select the present, inadequate drugs, design tests that give positive results and then with the aid of these tests to search for further compounds giving positive results. Such methodology may lead only to ‘old’ antiinflammatory agents instead of ‘new’.” More recently, Paulus and Whitehouse (1973) pointed out the lack of any breakthrough in the search for drugs to be used in the treatment of human arthritic disease.

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Authors
  1. M. E. J. Billingham
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  2. G. E. Davies
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  1. The Wellcome Research Laboratories, Langley Court, BR3 3BS, Beckenham, Kent, UK

    John R. Vane

  2. Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, CEP 14.100, São Paulo, Brazil

    Sergio H. Ferreira

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Billingham, M.E.J., Davies, G.E. (1979). Experimental Models of Arthritis in Animals as Screening Tests for Drugs to Treat Arthritis in Man. In: Vane, J.R., Ferreira, S.H. (eds) Anti-Inflammatory Drugs. Handbook of Experimental Pharmacology, vol 50 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66891-3_5

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