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Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties

  • Chapter
The Hepatitis C Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 242))

Abstract

Hepatitis C was first recognized as a distinct form of liver disease in the mid-1970s with the advent of diagnostic tests for hepatitis A and B virus infection (ALTER et al. 1975; PRINCE et al. 1974). The etiologic agent of hepatitis C was proposed to be a small, enveloped virus based on demonstrations of its transmissibility to chimpanzees (ALTER et al. 1978; HOLLINGER et al. 1978; TABOR et al. 1978), small size (< 80nm) (BRADLEY et al. 1985; HE et al. 1987), and sensitivity to chloroform (BRADLEY et al. 1983; FEINSTONE et al. 1983). The genome of hepatitis C virus (HCV) was first cloned in 1989 by screening a λgt11 cDNA expression library, derived from the plasma of a persistently infected chimpanzee, with hepatitis C patient serum (CHOO et al. 1989). Hybridization and nuclease digestion experiments indicated that the HCV genome consists of a single-stranded, positive-sense, RNA molecule (CHOO et al. 1989).

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  1. Department of Molecular Microbiology, Washington University School of Medicine, Campus Box 8230, 660 South Euclid Ave., St. Louis, MO, 63110-1093, USA

    K. E. Reed & C. M. Rice

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  1. Division of Digestive Diseases and Genetics — Winship Cancer Center, Emory University School of Medicine, 1639 Pierce Drive, Rm 2101 WMRB, 30322, Atlanta, GA, USA

    Curt H. Hagedorn M.D.

  2. Department of Molecular Microbiology, Washington University School of Medicine, 600 South Euclid Avenue, 63110, St. Louis, MO, USA

    Charles M. Rice M.D.

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Reed, K.E., Rice, C.M. (2000). Overview of Hepatitis C Virus Genome Structure, Polyprotein Processing, and Protein Properties. In: Hagedorn, C.H., Rice, C.M. (eds) The Hepatitis C Viruses. Current Topics in Microbiology and Immunology, vol 242. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59605-6_4

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  • DOI: https://doi.org/10.1007/978-3-642-59605-6_4

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