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A Critical Appraisal of the Role of Calcium Antagonists in the Management of Patients with Ischemic Heart Disease

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Book cover Heart Failure Mechanisms and Management

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Abstract

Chirac was probably the first investigator to describe the consequences of coronary artery ligation when, almost 300 years ago, he reported that hearts stop beating soon after coronary artery occlusion [1]. Chirac was describing the consequences of experimentally induced coronary insufficiency in dogs, but naturally occurring occlusions occur in man with equally undesirable consequences. The occlusions can occur for a variety of reason, such as coronary artery spasm, thrombosis, and atheroma. Inadequate perfusion can be triggered by other events, including a sustained increase in heart rate without an accompanying increase in coronary blood flow. Such a condition is encountered when the coronary vasculature is either stenosed, maximally dilated, or atheromatous. Severe systemic hypotension — such as that which occurs during shock or excessive vasodilator therapy — can also promote underperfusion.

This research was supported by a grant from the National Health and Medical Research Council of Australia.

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Authors
  1. W. G. Nayler
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Editors and Affiliations

  1. Department of Cardiology, Lady Davis Carmel Hospital, 34362, Haifa, Israel

    Basil S. Lewis MD (Director) (Director)

  2. University of California, Los Angeles, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

  3. Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA

    Asher Kimchi MD (Assistant Clinical Professor of Medicine, Attending Physician) (Assistant Clinical Professor of Medicine, Attending Physician)

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© 1991 Springer-Verlag Berlin Heidelberg

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Nayler, W.G. (1991). A Critical Appraisal of the Role of Calcium Antagonists in the Management of Patients with Ischemic Heart Disease. In: Lewis, B.S., Kimchi, A. (eds) Heart Failure Mechanisms and Management. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58231-8_31

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  • DOI: https://doi.org/10.1007/978-3-642-58231-8_31

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63509-0

  • Online ISBN: 978-3-642-58231-8

  • eBook Packages: Springer Book Archive

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