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The Macrophage as Therapeutic Target pp 67–87Cite as

Antigen-Presenting Cells and Vaccine Design

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 158))

Abstract

The innate immune system modulates antigen-specific adaptive immune responses in a qualitative and quantitative manner. In this chapter we propose that vaccine design would benefit from decoding this instructive function. We argue that the characterisation of cellular (particularly antigen-presenting cells) and soluble components of the innate system, and how they are interconnected, is an essential first step towards this goal.

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Abbreviations

APC:

Antigen-presenting cell

CR:

Complement receptor

DC:

Dendritic cell

Ig:

Immunoglobulin

LPS:

Lipopolysaccharide

MALT:

Mucosal associated lymphoid tissue

LRR:

Leucine-rich repeat

MØ:

Macrophage

MR:

Mannose receptor

MZ:

Marginal zone

PAMP:

Pathogen associated molecular pattern

Sn:

Sialoadhesin

SR-A:

Scavenger receptor class A

ss:

Subcapsular sinus

TD:

T-cell dependent

TI:

T-cell independent

TLR:

Toll-like receptor

TM:

Transmembrane

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Author information

Authors and Affiliations

  1. The Edward Jenner Institute for Vaccine Research, RG20 7NN, Newbury, Berkshire, UK

    S. Y. C. Wong

  2. The Sir William Dunn School of Pathology, Oxford University, South Parks Road, OX1 3RE, Oxford, UK

    L. Martinez-Pomares

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  1. S. Y. C. Wong
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  2. L. Martinez-Pomares
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Editors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, OX1 3RE, Oxford, UK

    Siamon Gordon

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© 2003 Springer-Verlag Berlin Heidelberg

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Wong, S.Y.C., Martinez-Pomares, L. (2003). Antigen-Presenting Cells and Vaccine Design. In: Gordon, S. (eds) The Macrophage as Therapeutic Target. Handbook of Experimental Pharmacology, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55742-2_5

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  • DOI: https://doi.org/10.1007/978-3-642-55742-2_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62919-8

  • Online ISBN: 978-3-642-55742-2

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