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Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligands for Antiviral Agents

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The Macrophage as Therapeutic Target

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 158))

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Abstract

Resident tissue macrophages are ideally placed for a role in the first line of defence against invading viruses and other microorganisms. Binding of viruses to macrophages can occur via a variety of molecules including the direct use of proteins, lipids and oligosaccharides as receptors, as well as opsonic recognition of viruses by the macrophage. Often multiple surface components are involved in virus-macrophage interactions, and interestingly a number of lectin receptors are expressed on macrophages for which viral ligands have been proposed. This review focuses on the initial viral attachment to macrophages and describes the interactions of certain macrophage lectin, proteoglycan and Toll-like receptors with viruses. The study of the role of pattern recognition receptors in the macrophage response to viruses may reveal new features of viral pathogenesis and some of the interactions could provide targets for antiviral agents.

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Abbreviations

APC:

Antigen-presenting cell

CMV:

Cytomegalovirus

CRD:

Carbohydrate recognition domain

DC:

Dendritic cell

GAG:

Glycosaminoglycan

HSV:

Herpes simplex virus

LPS:

Lipopolysaccharide

MBL:

Mannan-binding lectin

MR:

Mannose receptor

PAMP:

Pathogen-associated molecular pattern

PRR:

Pattern recognition receptor

RSV:

Respiratory syncytial virus

TLR:

Toll-like receptor

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    J. L. Miller & S. Gordon

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Miller, J.L., Gordon, S. (2003). Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligands for Antiviral Agents. In: Gordon, S. (eds) The Macrophage as Therapeutic Target. Handbook of Experimental Pharmacology, vol 158. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55742-2_21

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