Abstract
A review of the literature about the mechanism of action of angiotensin on the heart shows conflicting results. Some authors (Fowler and Holmes; Koch-Weser) conclude that angiotensin acts exclusively by a direct action, whereas others as for instance Krasney et al. (1965, 1966) postulate that it acts in addition by an indirect adrenergic mechanism. Since the argumentation is mostly based on experiments with cardiac denervation and antagonists without determination of the adrenergic transmitter, it was our aim to contribute to the elucidation of the mechanism of action of angiotensin by measuring the noradrenaline output of the isolated perfused heart at different experimental conditions.
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References
Finkielman, S., Worcel, M., Massani, Z. M., Narmod, V. E., Paladini, A. C., Agrest, A.: Angiotensin blood levels in hypovolemic shock during osmotic diuresis. Amer. J. Physiol. 215, 308–313 (1968).
Fowler, N. O., Holmes, J. C.: Coronary and myocardial action of angiotensin. Circulat. Res. 14, 191–201 (1964).
Hertting, G., Schieftraler, TH.: Beziehung zwischen Durchflußgröße und Noradrenalinfreisetzung bei Nervenreizung der isoliert durchströmten Katzenmilz. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak 246, 13–14 (1963).
Hucovié, S., Muscuoll, E.: Die Noradrenalin-Abgabe aus dem isolierten Kaninchenherzen bei sympathischer Nervenreizung und ihre pharmakologische Beeinflussung. NaunynSchmiedebergs Arch. exp. Path. Pharmak. 244, 81–96 (1962).
Koch-Weser, J.: Nature of the inotropic action of angiotensin on ventricular myocardium. Circulat. Res. 16, 230–237 (1965).
Krasney, J. A., Paddler, F. T., Hogan, P. M., Lowe, R. F., Youmans, W. B.: Peripheral adrenergic basis for cardioaccelerator action of angiotensin. Amer. J. Physiol. 211, 1447–1450 (1966).
Krasney, J. A., Paddler, F. T., Smith, D. C., Davis, L. D., Youmans, W. B.: Mechanisms of cardioaccelerator action of angiotensin. Amer. J. Physiol. 209, 539–544 (1965).
Massani, Z. M., Finkielman, S., Worcel, M., Agrest, A., Paladini, A. C.: Angiotensin blood levels in hypertensive and non-hypertensive diseases. Clin. Sci. 30, 473–483 (1966).
Paton, D. M., Gillis, C. N.: Effect of altered perfusion rates on the retention of noradrenaline by the spleen. Nature (Lond.) 208, 391–392 (1965).
Rosell, S., Kopnn, I. J., Axelrod, J.: Fate of H3-norepinephrine in skeletal muscle before and following sympathetic stimulation. Amer. J. Physiol. 205, 317–321 (1963).
Starke, K., Werner, U., Schumann, H. J.: Wirkung von Angiotensin auf Funktion und Noradrenalinabgabe isolierter Kaninchenherzen in Ruhe und bei Sympathicusreizung. Naunyn-Schmiedebergs Arch. Pharmak. 265, 170–186 (1969).
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Schümann, HJ. (1970). Effect of Angiotensin on Noradrenaline Release of the Isolated Rabbit Heart. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49747-6_18
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DOI: https://doi.org/10.1007/978-3-642-49747-6_18
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