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New Aspects of Storage and Release Mechanisms of Catecholamines pp 161–167Cite as

Saturation of the Uptake of Noradrenaline as a Determinant of Pharmacological Effects

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Part of the book series: Bayer Symposium ((BAYER-SYMP,volume 2))

Abstract

Intraneuronal uptake is responsible for the removal of 1-noradrenaline from the fluid perfusing isolated rabbit hearts (Lindmarand Muscxoll, 1964). In this species, the uptake mechanism is characterized by lacking stereospecificity and by being saturable; however, in spite of the lack of stereospecificity, the rate of uptake of d-noradrenaline is lower than that of the 1-isomer when the heart is perfused with a concentration of the amine (200 ng/ml) that causes partial saturation of uptake (DraskÓczy and Trendelenburg, 1968).

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References

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Authors and Affiliations

  1. Institut für Pharmakologie, Toxikologie der Universität, D-8700, Würzburg, Koellikerstraße 2, Deutschland

    Prof. Dr. U. Trendelenburg

Authors
  1. Prof. Dr. U. Trendelenburg
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  2. P. R. Draskóczy
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  3. K.-H. Graefe
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  4. H. Hennemann
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Editor information

Editors and Affiliations

  1. Klinikum Essen, Ruhruniversität Bochum, 4300, Essen-Holsterhausen, Deutschland

    Hans-Joachim Schümann (Direktor des Pharmakologischen Institutes) (Direktor des Pharmakologischen Institutes)

  2. Farbenfabriken Bayer AG., 5600, Wuppertal-Elberfeld, Deutschland

    Günter Kroneberg (Vorstand des Institutes für Pharmakologie) (Vorstand des Institutes für Pharmakologie)

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© 1970 Springer-Verlag

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Trendelenburg, U., Draskóczy, P.R., Graefe, KH., Hennemann, H. (1970). Saturation of the Uptake of Noradrenaline as a Determinant of Pharmacological Effects. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49747-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-49747-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-49465-9

  • Online ISBN: 978-3-642-49747-6

  • eBook Packages: Springer Book Archive

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