Abstract
It often seems assumed that under normal conditions the amount of transmitter, released at neuro-effector junctions per impulse, is largely constant at a given physiological rate of discharge, being composed of a certain number of transmitter “quanta” (cf. Eccles, 1964). Under experimental conditions, however, the amount of acetylcholine in a quantum can be modified (Eccles, 1964). Furthermore, a deficency of acetylcholine in the presynaptically formed quanta is discussed at myastenia gravis (Elmqvist, 1965). However, variations in the transmitter content in tissues (after blockade of synthesis) or in the overflow of the transmitter into a tissue perfusate during e.g. sympathetic nerve activity, are mostly ascribed to either a changed rate of impulse flow, or to variations in the inactivation of the amount of noradrenaline (NA) released per nerve impulse.
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Häggendal, J. (1970). Some Further Aspects on the Release of the Adrenergic Transmitter. In: Schümann, HJ., Kroneberg, G. (eds) New Aspects of Storage and Release Mechanisms of Catecholamines. Bayer Symposium, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49747-6_11
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DOI: https://doi.org/10.1007/978-3-642-49747-6_11
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